The Optimization of Porous Materials for Immobilized Enzyme (IME) Systems

  • David L. Eaton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 42)


Critical parameters involved in the selection of support materials in the immobilization of biologically active materials are discussed. The importance of physical properties such as pore morphology, surface area and particle size relative to the final activity of the enzyme is shown using glucoamylase IME as a model system. The process of selection of specific materials with respect to the environmental conditions of the enzyme and the chemical durability of the support is considered, as are the mechanical properties required in the scale up of an application.


Porous Material Immobilize Enzyme Carrier Material Pore Morphology Chemical Durability 
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  1. (1).
    Haller, W., “Rearrangement Kinetics of the Liquid-Liquid Immiscible Microphases in Alkali Borosilicate Melts”, J. Chem. Phys. Vol. 42, No. 2, pp 686–693 (1965).CrossRefGoogle Scholar
  2. (2).
    Dementeva, M.I., et al, “Applications of CourselyPorous Glass in Gas-Liquid Chromatography,” Rus.J.Phys. Chem., Vol. 36, No. 1, p. 114 (1962).Google Scholar
  3. (3).
    Messing, R.A., “A Glucose Oxidase-Catalase System Immobilized in Control Pore Titania Monitored by a Conductiometric Technique,” presented at the 166th ACS National Meeting, Chicago, Illinois, 8/27–8/31/73. To be published in the Proceeding of the ACS Immobilized Enzyme Symposium by the Plenum Publishing Corp.Google Scholar
  4. (4).
    Turba, E., “Behavior of Powders Compacted in a Die,” Proc. Brit. Ceram. Soc., No. 3, 101–115 (1965).Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • David L. Eaton
    • 1
  1. 1.Corning Glass WorksCorningUSA

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