Advertisement

Immunological Studies of Brain Specific Protein

  • Krystyna Warecka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 32)

Abstract

We have found a glycoprotein in human brain which is brain specific on immunological criteria (7). As can be seen in Fig.1A, immune sera prepared against white matter, give precipitation bands with aqueous extracts from white matter. Only one band remains if this serum is absorbed with human serum and organ extracts (Fig.1B). After absorption of the immune serum with liver and kidney extracts, only the brain specific band can be seen. The protein migrates in the alpha2 area, and by immunoelectrqphoretic analysis gives a sharply defined, rather straight precipitation line which terminates as a semi-circle around the application well (Fig. 2 ).

Keywords

Brain Extract Neuraminic Acid Neuronal Perikaryon Lower Hole Precipitation Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Axen, R., Prath, J. and Ernback, S., Nature, 214 (1967) 1302.CrossRefGoogle Scholar
  2. 2.
    Gray, E.G. and Whittaker, V.P., J. Anat., 96 (1962) 79.Google Scholar
  3. 3.
    Rose, S.P.R., Biochem. J., 102 (1967) 33.Google Scholar
  4. 4.
    Tripatzis, I., Warecka, K. and Man-Chung Wong, Nature, 230 (1971) 250.Google Scholar
  5. 5.
    Warecka, K., Habilitationsschrift, 1969.Google Scholar
  6. 6.
    Warecka, K., J. Neurochem., 17 (1970) 829.CrossRefGoogle Scholar
  7. 7.
    Warecka, K. and Bauer, H., Dtsch. Z. Nervenheilk., 189 (1966) 53.CrossRefGoogle Scholar
  8. 8.
    Warecka, K. and Bauer, H., J. Neurochem., 14 (1967) 783.CrossRefGoogle Scholar
  9. 9.
    Warecka, K. and Müller, D., J. Neurol. Sci., 8 (1969) 329.CrossRefGoogle Scholar
  10. 10.
    Warecka, K., Müller, D. and Peters, K., in preparation.Google Scholar
  11. 11.
    Warecka, K., Möller, H.J., Vogel, H.M. and Tripatzis, I., J. Neurochem., 19 (1972) 719.CrossRefGoogle Scholar
  12. 12.
    Warecka, K. and Vogel, H.M., in preparation.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Krystyna Warecka
    • 1
  1. 1.NervenklinikMedizinischen Akademie Lübeck (24)Germany

Personalised recommendations