Chemistry and Biology of Two Brain-Specific Proteins, S-100 and 14-3-2

  • B. W. Moore
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 32)

Abstract

During development the cells of the nervous system differentiate greatly, leading to the presence in mature brain of many highly specific forms and functions such as the occurrence of the two basic cell types, neurons and glia; cell processes of neurons and glia; microtubular systems; the apparatus at nerve endings including metabolic systems for transmitter synthesis and degradation, vesicles, and specialized membranes; propagation of action potentials; axoplasmic flow; synaptic transmission; and the establishment of specific connections. The way in which genetic information is expressed during differentiation is mediated through synthesis of specific protein molecules; therefore there should be proteins which are specific to the nervous system related to specific neural forms and functions. Furthermore, if these forms and functions are truly general, such proteins should be present in nervous systems of all species. Our work has focussed on looking for nervous system-specific, species non-specific proteins.

Keywords

Tyrosine Cysteine Electrophoresis Resi Phenylalanine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Benda, P., Lightbody, J., Sato, G., Levine, L. and Sweet, W., Science, 161 (1968) 370.CrossRefGoogle Scholar
  2. 2.
    Calissano, P., Moore, B.W. and Friesen, A., Biochemistry, 8 (1969) 4318.CrossRefGoogle Scholar
  3. 3.
    Cicero, T.J., unpublished.Google Scholar
  4. 4.
    Cicero, T.J. and Moore, B.W., unpublished.Google Scholar
  5. 5.
    Cicero, T.J., Cowan, W.M. and Moore, B.W., Brain Res., 24 (1966) 1.CrossRefGoogle Scholar
  6. 6.
    Cicero, T.J., Cowan, W.M., Moore, B.W. and Suntzeff, V., Brain Res., 18 (1970) 25.CrossRefGoogle Scholar
  7. 7.
    Gombos, G., Vincendon, G., Tardy, J. and Mandel, P., C.R. Acad. Sci.(Paris) Sér.D., 263 (1966) 1533.Google Scholar
  8. 8.
    Hyden, H. and McEwen, B., Proc. Natl. Acad. Sci. US, 55 (1966) 354.CrossRefGoogle Scholar
  9. 9.
    Moore, B.W., Biochem. Biophys. Res. Commun., 19 (1965) 739.CrossRefGoogle Scholar
  10. 10.
    Moore, B.W., in Handbook of Neurochemistry (Ed. Lajtha, A.) Plenum Press, 1969, vol. 1, p.93.Google Scholar
  11. 11.
    Moore, B.W. and Perez, V.J., in Physiological and Biochemical Aspects of Nervous Integration (Ed. Carlson, F.D.), Prentice-Hall, Englewood Cliffs, New Jersey, 1968, p.343.Google Scholar
  12. 12.
    Perez, V.J. and Moore, B.W., unpublished.Google Scholar
  13. 13.
    Perez, V.J., Olney, J.W., Cicero, T.J., Moore, B.W. and Bahn, B.A., J. Neurochem., 17 (1970) 511.CrossRefGoogle Scholar
  14. 14.
    Vincendon, G., Waksman, A., Uyemura, K., Tardy, J. and Gombos, G., Arch. Biochem. Biophys., 120 (1967) 233.CrossRefGoogle Scholar
  15. 15.
    Zuckerman, J.E., Herschmann, H.R. and Levine, L., J. Neurochem., 17 (1970) 247.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • B. W. Moore
    • 1
  1. 1.Department of PsychiatryBarnes and Renard HospitalsSt. LouisUSA

Personalised recommendations