Chemistry and Biology of Two Brain-Specific Proteins, S-100 and 14-3-2

  • B. W. Moore
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 32)


During development the cells of the nervous system differentiate greatly, leading to the presence in mature brain of many highly specific forms and functions such as the occurrence of the two basic cell types, neurons and glia; cell processes of neurons and glia; microtubular systems; the apparatus at nerve endings including metabolic systems for transmitter synthesis and degradation, vesicles, and specialized membranes; propagation of action potentials; axoplasmic flow; synaptic transmission; and the establishment of specific connections. The way in which genetic information is expressed during differentiation is mediated through synthesis of specific protein molecules; therefore there should be proteins which are specific to the nervous system related to specific neural forms and functions. Furthermore, if these forms and functions are truly general, such proteins should be present in nervous systems of all species. Our work has focussed on looking for nervous system-specific, species non-specific proteins.


Tyrosine Cysteine Electrophoresis Resi Phenylalanine 


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • B. W. Moore
    • 1
  1. 1.Department of PsychiatryBarnes and Renard HospitalsSt. LouisUSA

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