Isolation and Characterization of Myelin Protein from Adult Quaking Mice and its Similarity to Myelin Protein of Young Normal Mice
Quaking is a genetically determined neurological disorder of mice in which the homozygotes are characterized by marked tremors and seizures. Sidman, Dickie and Appel (16) demonstrated histologically that the CNS showed incomplete myelination without marked changes in the axons. Ultrastructural studies (4, 18) have shown that the myelin sheaths are thin and uncompacted, that there is uneven growth of lateral loops, and that nodes of Ranvier are poorly developed (Fig. 1). These observations regarding the CNS of the mature Quaking mouse are very similar to those seen in the normal mouse during the early period of myelinogenesis (8–12 days).
KeywordsBasic Protein Sodium Lauryl Sulfate Myelin Protein High Molecular Weight Protein Proteolipid Protein
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- 1.Agrawal, H.C., Banik, N.L., Bone, A.H., Davison, A.N., Mitchell, R.F. and Spohn, M., Biochem. J., 120 (1970) 635.Google Scholar
- 2.Banik, N.L. and Davison, A.N., Biochem. J., 115 (1969) 1051.Google Scholar
- 11.Martenson, R.E., Diebler, G.E. and Kies, M.W., J. Biol. Chem., 244 (1969) 4268.Google Scholar
- 17.Singh, H., Spritz, N. and Geyer, B., J. Lipid Res., 12 (1971) 473.Google Scholar