Abstract
Quaking is a genetically determined neurological disorder of mice in which the homozygotes are characterized by marked tremors and seizures. Sidman, Dickie and Appel (16) demonstrated histologically that the CNS showed incomplete myelination without marked changes in the axons. Ultrastructural studies (4, 18) have shown that the myelin sheaths are thin and uncompacted, that there is uneven growth of lateral loops, and that nodes of Ranvier are poorly developed (Fig. 1). These observations regarding the CNS of the mature Quaking mouse are very similar to those seen in the normal mouse during the early period of myelinogenesis (8–12 days).
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References
Agrawal, H.C., Banik, N.L., Bone, A.H., Davison, A.N., Mitchell, R.F. and Spohn, M., Biochem. J., 120 (1970) 635.
Banik, N.L. and Davison, A.N., Biochem. J., 115 (1969) 1051.
Baumann, N.A., Jacque, C.M., Pollet, S.A. and Harpin, M.L., Europ. J. Biochem., 4 (1968) 340.
Berger, B., Brain Res., 25 (1971) 35.
Bowen, D.M. and Radin, N.S., J. Neurochem., 16 (1968) 457.
Costantino-Ceccarubu, E. and Morell, P., Brain Res., 29 (1971) 75.
Gonzalez-Sastre, F., J. Neurochem., 17 (1970) 1049.
Greenfield, S., Norton, W.T. and Morell, P., J. Neurochem., 18 (1971) 2119.
Hogan, E.L. and Joseph, K.C., J. Neurochem., 17 (1970) 1209.
Laemmli, U.K., Nature (Lond.), 227 (1970) 680.
Martenson, R.E., Diebler, G.E. and Kies, M.W., J. Biol. Chem., 244 (1969) 4268.
Neskovic, N., Nussbaum, J.L. and Mandel, P., Brain Res., 21 (1970) 39.
Norton, W.T., in Chemistry and Brain Development (Ed. Paoletti, R. and Davison, A.) Plenum Press, New York, 1971, p.327.
Raine, C.S., Poduslo, S.E., and Norton, W.T., Brain Res., 27 (1970) 11.
Reasor, M.J. and Kanfer, J.N., Life Sci., 8 (1969) 1055.
Sidman, R.L., Dickie, M.M. and Appel, S.H., Science, 144 (1964) 309.
Singh, H., Spritz, N. and Geyer, B., J. Lipid Res., 12 (1971) 473.
Wisniewski, H. and Morell, P., Brain Res., 29 (1971) 63.
Wolfgram, F. and Kotorii, K., J. Neurochem., 15 (1968) 1281.
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Morell, P., Greenfield, S., Norton, W.T., Wisniewski, H. (1972). Isolation and Characterization of Myelin Protein from Adult Quaking Mice and its Similarity to Myelin Protein of Young Normal Mice. In: Davison, A.N., Mandel, P., Morgan, I.G. (eds) Functional and Structural Proteins of the Nervous System. Advances in Experimental Medicine and Biology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6979-0_18
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DOI: https://doi.org/10.1007/978-1-4684-6979-0_18
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