Isolation and Characterization of Myelin Protein from Adult Quaking Mice and its Similarity to Myelin Protein of Young Normal Mice

  • Pierre Morell
  • Seymour Greenfield
  • William T. Norton
  • Henry Wisniewski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 32)


Quaking is a genetically determined neurological disorder of mice in which the homozygotes are characterized by marked tremors and seizures. Sidman, Dickie and Appel (16) demonstrated histologically that the CNS showed incomplete myelination without marked changes in the axons. Ultrastructural studies (4, 18) have shown that the myelin sheaths are thin and uncompacted, that there is uneven growth of lateral loops, and that nodes of Ranvier are poorly developed (Fig. 1). These observations regarding the CNS of the mature Quaking mouse are very similar to those seen in the normal mouse during the early period of myelinogenesis (8–12 days).


Basic Protein Sodium Lauryl Sulfate Myelin Protein High Molecular Weight Protein Proteolipid Protein 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Pierre Morell
    • 1
  • Seymour Greenfield
    • 1
  • William T. Norton
    • 1
  • Henry Wisniewski
    • 1
  1. 1.Saul R. Korey Department of Neurology and Department of Pathology (Neuropathology)Albert Einstein College of MedicineBronxUSA

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