Myelin Basic Proteins

  • Marian W. Kies
  • Russell E. Martenson
  • Gladys E. Deibler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 32)


Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter. At that time the existence in myelin of a highly basic protein resembling certain of the histones was not even suspected. Early studies on the isolation of the encephalitogenic component of guinea pig central nervous system (CNS) tissue and its subsequent purification depended largely on bioassay of fractions for encephalitogenic activity (13). Although the basic nature and high cathodic electrophoretic mobility of the encephalitogenic protein were soon recognized (14), the available electrophoretic techniques were not adequate for critical monitoring of the purification procedures. Since the concentration of this protein in CNS tissue is high, its isolation was relatively simple, and sufficient quantities could be prepared for detailed studies of its chemical properties and structure.


Myelin Basic Protein Experimental Allergic Encephalomyelitis Myelin Protein Central Nervous System Tissue Half Cystine 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Marian W. Kies
    • 1
  • Russell E. Martenson
    • 1
  • Gladys E. Deibler
    • 1
  1. 1.Section on Myelin Chemistry, Laboratory of Cerebral MetabolismNational Institute of Mental HealthBethesdaUSA

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