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Myelin Basic Proteins

  • Marian W. Kies
  • Russell E. Martenson
  • Gladys E. Deibler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 32)

Abstract

Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter. At that time the existence in myelin of a highly basic protein resembling certain of the histones was not even suspected. Early studies on the isolation of the encephalitogenic component of guinea pig central nervous system (CNS) tissue and its subsequent purification depended largely on bioassay of fractions for encephalitogenic activity (13). Although the basic nature and high cathodic electrophoretic mobility of the encephalitogenic protein were soon recognized (14), the available electrophoretic techniques were not adequate for critical monitoring of the purification procedures. Since the concentration of this protein in CNS tissue is high, its isolation was relatively simple, and sufficient quantities could be prepared for detailed studies of its chemical properties and structure.

Keywords

Myelin Basic Protein Experimental Allergic Encephalomyelitis Myelin Protein Central Nervous System Tissue Half Cystine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Agrawal, H.C., Banik, N.L., Bone, A.H., Davison, A.N., Mitchell, R.F. and Spohn, M., Biochem. J., 120 (1970) 635.Google Scholar
  2. 2.
    Carnegie, P.R., Biochem. J., 123 (1971) 57.Google Scholar
  3. 3.
    Cotman, C.W. and Mahler, H.R., Arch. Biochem. Biophys., 120 (1967) 384.CrossRefGoogle Scholar
  4. 4.
    Deibler, G., Martenson, R., and Kies, M., 2nd National Meeting of the American Society for Neurochemistry, Hershey, Pa., 1971, Abstr. p.66.Google Scholar
  5. 5.
    Edelhoch, H., Biochemistry, 6 (1967) 1948.CrossRefGoogle Scholar
  6. 6.
    Eng, L.F., Chao, F.C., Gerstl, B., Pratt, D. and Tavaststjerna, M.G., Biochemistry, 7 (1968) 4455.CrossRefGoogle Scholar
  7. 7.
    Eylar, E.H., Proc. Natl. Acad. Sci. US, 67 (1970) 1425.CrossRefGoogle Scholar
  8. 8.
    Eylar, E.H., Caccam, J., Jackson, J.J., Westall, F.A. and Robinson, A.B., Science, 168 (1970) 1220.CrossRefGoogle Scholar
  9. 9.
    Folch, J., Ascoli, I., Lees, M., Meath, J.A. and LE Baron, F.N., J. Biol. Chem., 191 (1951) 833.Google Scholar
  10. 10.
    Greenfield, S., Norton, W.T. and Morell, P., 2nd National Meeting of the American Society for Neurochemistry, Hershey, Pa., 1971, Abstr. p.76.Google Scholar
  11. 11.
    Kabat, E.A., Wolf, A. and Bezer, A.E., J. Exptl. Med., 85 (1947) 117.CrossRefGoogle Scholar
  12. 12.
    Kies, M.W., Ann. N.Y. Acad. Sci., 122 (1965) 161.CrossRefGoogle Scholar
  13. 13.
    Kies, M.W. and Alvord, E.C. Jr., in Allergie Encephalomyelitis (Ed. Kies, M.W. and Alvord, E.C. Jr.) Charles C. Thomas, Springfield, 1959), p.293.Google Scholar
  14. 14.
    Kies, M.W., Murphy, J.B. and Alvord, E.C. Jr., in Chemical Pathology of the Nervous System (Ed. Folch-PI, J.) Pergamon Press, London, 1961, p.197.Google Scholar
  15. 15.
    Laatsch, R.H., Kies, M.W., Gordon, S. and Alvord, E.C. Jr., J. Exptl. Med., 115 (1962) 777.CrossRefGoogle Scholar
  16. 16.
    Lennon, V.A., Wilks, A.V. and Carnegie, P.R., J. Immunol., 105 (1970) 1223.Google Scholar
  17. 17.
    Martenson, R.E., Deibler, G.E. and Kies, M.W., J. Biol. Chem., 244 (1969) 4261; 4268.Google Scholar
  18. 18.
    Martenson, R.E., Deibler, G.E. and Kies, M.W., Biochim.Biophys. Acta, 200 (1970) 353.Google Scholar
  19. 19.
    Martenson, R.E., Deibler, G.E. and Kies, M.W., in Immunological Disorders of the Nervous System, Proc. Ass. Res. Nerv. Ment. Dis., vol. XLIX (Ed. Rowland, L.P.) Williams and Wilkins, Baltimore, 1971, p.76.Google Scholar
  20. 20.
    Martenson, R.E., Deibler, G.E. and Kies, M.W., J. Neurochem., 18 (1971) 2417.CrossRefGoogle Scholar
  21. 21.
    Martenson, R.E., Deibler, G.E. and Kies, M.W., J. Neurochem., 18 (1971) 2427.CrossRefGoogle Scholar
  22. 22.
    Martenson, R.E., Deibler, G.E. and Kies, M.W., Nature New Biol. (Lond.) 234 (1971) 87.Google Scholar
  23. 23.
    Martenson, R.E., Deibler, G.E., Kies, M.W., McKneally, S., Shapira, R. and Kibler, R.F., Biochim. Biophys.Acta, 263 (1972) 193.Google Scholar
  24. 24.
    Martenson, R.E. and Gaitonde, M.K., J. Neurochem., 16 (1969) 889.CrossRefGoogle Scholar
  25. 25.
    Mehl, E. and Halaris, A., J. Neurochem., 17 (1970) 659.CrossRefGoogle Scholar
  26. 26.
    Morgan, I.M., J. Exptl. Med., 85 (1947) 131.CrossRefGoogle Scholar
  27. 27.
    Morris, D., in The Mammals, Harper and Row, New York, 1965, p.184.Google Scholar
  28. 28.
    Nakao, S. and Roboz-Einstein, E., Ann. N.Y. Acad. Sci.US, 122 (1965) 171.CrossRefGoogle Scholar
  29. 29.
    Shapira, R., Chou, F. C-H, McKneally, S., Urban, E. and Kibler, R.F., Science, 173 (1971) 736.CrossRefGoogle Scholar
  30. 30.
    Shapira, R., McKneally, S.S., Chou, F., and Kibler, R.F., J. Biol. Chem., 246 (1971) 4630.Google Scholar
  31. 31.
    Swanborg, R.H. and Amesse, L.S., J. Immunol., 107 (1971) 281.Google Scholar
  32. 32.
    Tomasi, L.G. and Kornguth, S.E., J. Biol. Chem., 242 (1967) 4933.Google Scholar
  33. 33.
    Tomasi, L.G. and Kornguth, S.E., J. Biol. Chem., 243 (1968) 2507.Google Scholar
  34. 34.
    Waehneldt, T.V. and Mandel, P., Febs Letters, 9 (1970) 209.CrossRefGoogle Scholar
  35. 35.
    Wood, J.G. and King, N., Nature, 229 (1971) 56.CrossRefGoogle Scholar
  36. 36.
    Kibler, R.F., Re’, P.K., MeKneally, S. and Shapira, R., J. Biol. Chem., 247 (1972) 969.Google Scholar
  37. 37.
    Agrawal, H.C., Banik, N.L., Bone, A.H., Cuzner, M.L., Davison, A.N. and Mitchell, R.F., Biochem. J., 124 (1971) 70P.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Marian W. Kies
    • 1
  • Russell E. Martenson
    • 1
  • Gladys E. Deibler
    • 1
  1. 1.Section on Myelin Chemistry, Laboratory of Cerebral MetabolismNational Institute of Mental HealthBethesdaUSA

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