The Cyclic Helix and Cyclic Coil Forms of Polyoma Viral DNA

  • Roger Weil
  • Jerome Vinograd
Part of the Milestones in Current Research book series (MCR)


The DNA extracted from polyoma virus exhibits certain properties which have not been reported for other viral base-paired DNA’s.1 The DNA renatures monomolecularly. The loss of helical configuration does not impair biological activity. Heating at 100° for 10–20 min followed by rapid cooling does not reduce the infective titer. Dulbecco has given evidence suggesting that a fraction of the polyoma DNA molecules are cyclic.2 This form would in part account for the above properties.


Sedimentation Velocity Linear Molecule Sedimentation Coefficient Buoyant Density Polyoma Virus 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Roger Weil
  • Jerome Vinograd

There are no affiliations available

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