Growth Control in Cultured Cells: Selection of Sublines with Increased Sensitivity to Contact Inhibition and Decreased Tumor-Producing Ability

  • Robert E. Pollack
  • Howard Green
  • George J. Todaro
Part of the Milestones in Current Research book series (MCR)


As growing cultures of mammalian cells reach a high density, their growth rate decreases and in some cases a substantially nondividing population may result. This arrest of growth requires cell contact,1, 2 though soluble substances are also involved.3–5 The phenomenon has usually been called contact inhibition of division.


Cell Density Contact Inhibition Saturation Density Polyoma Virus Culture Behavior 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Robert E. Pollack
  • Howard Green
  • George J. Todaro

There are no affiliations available

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