Abortive Transformation by Polyoma Virus
Exposure of hamster cells to large doses of polyoma virus is known to result in permanent transformation of a small proportion of cells. Experiments with cells in suspension now suggest that a much higher proportion of infected cells undergoes a temporary change, in which at least one characteristic of transformation is acquired for a few cell divisions and then lost again. Thissuggests that acquisition of the transformed phenotypes does not depend upon stable integration of the viral genome.
KeywordsInfected Cell BHK21 Cell Fluid Medium Complement Fixation Test Virus Suspension
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