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The Transcription of the SV40 Genome in Productively Infected and Transformed Cells

  • G. Sauer
  • J. R. Kidwai
Part of the Milestones in Current Research book series (MCR)

Abstract

A particular feature of cells which have been transformed by DNA-containing tumor viruses is the restricted expression of the viral genome. These cells do not display any of the viral functions which occur late during a productive cycle of infection—such as extensive replication of the viral DNA, production of viral coat protein, and maturation of infectious viral progeny. They do contain, however, tumor antigen which is synthesized early after infection. Hence, it appears that in transformed cells only “early” but no “late” products are being synthesized.

Keywords

Viral Genome Viral Coat Protein Cell Species SV40 Genome Infectious Viral Progeny 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

  1. 1.
    Axelrod, D., E. T. Bolton, and K. Habel, Science, 146, 1466 (1964).PubMedCrossRefGoogle Scholar
  2. 2.
    Benjamin, T. L., J. Mol. Biol., 16, 359 (1966).PubMedCrossRefGoogle Scholar
  3. 3.
    Koprowski, H., F. C. Jensen, and Z. Steplewski, these Proceedings, 58, 127 (1967).Google Scholar
  4. 4.
    Westphal, H., and R. Dulbecco, these Proceedings, 59, 1158 (1968).Google Scholar
  5. 5.
    Aloni, Y., E. Winocour, and L. Sachs, J. Mol. Biol., 31, 415 (1968).PubMedCrossRefGoogle Scholar
  6. 6.
    Oda, K., and R. Dulbecco, these Proceedings, 60, 525 (1968).Google Scholar
  7. 7.
    Fernandes, M. V., and P. S. Moorhead, Texas Rep. Biol. Med., 23, 242 (1965).Google Scholar
  8. 9.
    Girardi, A. J., these Proceedings, 54, 445 (1965).Google Scholar
  9. 10.
    Jensen, F. C., A. J. Girardi, R. V. Gilden, and H. Koprowski, these Proceedings, 52, 53 (1964).Google Scholar
  10. 11.
    Todaro, G. J., H. Green, and B. D. Goldberg, these Proceedings, 51, 66 (1964).Google Scholar
  11. 13.
    Mandell, J. D., and A. D. Hershey, Anal. Biochem., 1, 78 (1960).CrossRefGoogle Scholar
  12. 14.
    Gillespie, D., and S. Spiegelman, J. Mol. Biol., 12, 829 (1965).PubMedCrossRefGoogle Scholar
  13. 15.
    Todaro, G. J., and H. Green, these Proceedings, 55, 302 (1966).Google Scholar
  14. 16.
    Watkins, J. F., and R. Dulbecco, these Proceedings, 58, 1396 (1967).Google Scholar
  15. 17.
    Sauer, G, H. Koprowski, and V. Defendi, these Proceedings, 58, 599 (1967).Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • G. Sauer
  • J. R. Kidwai

There are no affiliations available

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