The Transcription of the SV40 Genome in Productively Infected and Transformed Cells
A particular feature of cells which have been transformed by DNA-containing tumor viruses is the restricted expression of the viral genome. These cells do not display any of the viral functions which occur late during a productive cycle of infection—such as extensive replication of the viral DNA, production of viral coat protein, and maturation of infectious viral progeny. They do contain, however, tumor antigen which is synthesized early after infection. Hence, it appears that in transformed cells only “early” but no “late” products are being synthesized.
KeywordsViral Genome Viral Coat Protein Cell Species SV40 Genome Infectious Viral Progeny
Unable to display preview. Download preview PDF.
- 3.Koprowski, H., F. C. Jensen, and Z. Steplewski, these Proceedings, 58, 127 (1967).Google Scholar
- 4.Westphal, H., and R. Dulbecco, these Proceedings, 59, 1158 (1968).Google Scholar
- 6.Oda, K., and R. Dulbecco, these Proceedings, 60, 525 (1968).Google Scholar
- 7.Fernandes, M. V., and P. S. Moorhead, Texas Rep. Biol. Med., 23, 242 (1965).Google Scholar
- 9.Girardi, A. J., these Proceedings, 54, 445 (1965).Google Scholar
- 10.Jensen, F. C., A. J. Girardi, R. V. Gilden, and H. Koprowski, these Proceedings, 52, 53 (1964).Google Scholar
- 11.Todaro, G. J., H. Green, and B. D. Goldberg, these Proceedings, 51, 66 (1964).Google Scholar
- 15.Todaro, G. J., and H. Green, these Proceedings, 55, 302 (1966).Google Scholar
- 16.Watkins, J. F., and R. Dulbecco, these Proceedings, 58, 1396 (1967).Google Scholar
- 17.Sauer, G, H. Koprowski, and V. Defendi, these Proceedings, 58, 599 (1967).Google Scholar