Virus-Specific RNA in Cells Productively Infected or Transformed by Polyoma Virus
Virus-specific RNA is detected in mouse kidney cells infected by polyoma virus by means of hybridization between [3H]thymidine-labeled virus DNA and 32P pulse-labeled RNA. Small amounts of “early” RNA are observed before virus DNA synthesis begins; during the later phases of virus development, there is a sharp increase in the amount of virus-specific RNA. Synthesis of mouse RNA occurs, and is possibly stimulated, during the infection.
KeywordsPolyoma Virus Sodium Naphthalene Mouse Kidney Cell Naphthalene Disulfonate Virus Growth Cycle
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