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Synthesis of SV40 Tumor Antigen during Replication of Simian Papovavirus (SV40)

  • F. Rapp
  • T. Kitahara
  • J. S. Butel
  • J. L. Melnick
Part of the Milestones in Current Research book series (MCR)

Abstract

Hamsters bearing tumors induced either by simian papovavirus 40 (SV40) or by cells tranformed in vitro by the virus develop antibodies capable of detecting a new complement-fixing antigen in the transformed cells.1 Antibodies also develop for a new intranuclear antigen present in all cells transformed by SV40 and detected by the immunofluorescence technique.2, 3 It appears that the new antigens detected by complement-fixation and by immunofluorescence are similar or identical immunologically.4 The new tumor antigen is presumably under control of at least a portion of the virus genome, but some of the cell lines producing the antigen do not go on to synthesize infectious SV40.5 The present experiments, and those reported in the accompanying paper,6 were designed to determine whether cells susceptible to SV40 produced the tumor antigens in the course of the replication of the virus.

Keywords

Tumor Antigen Viral Antigen Monkey Cell Embryonic Human Lung SV40 Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

  1. 1.
    Black, P. H., W. P. Rowe, H. C. Turner, and R. J. Huebner, these Proceedings 50, 1148 (1963).Google Scholar
  2. 2.
    Pope, J. H., and W. P. Rowe, J. Exptl. Med., 120, 121 (1964).CrossRefGoogle Scholar
  3. 5.
    Melnick, J. L., K. S. Khera, and F. Rapp, Virology, 23, 430 (1964).PubMedCrossRefGoogle Scholar
  4. 6.
    Sabin, A. B., and M. A. Koch, these Proceedings, 52, 1131 (1964).Google Scholar
  5. 7.
    Hopps, H. E., B. C. Bernheim, A. Nisalak, J. H. Tjio, and J. E. Smadel, J. Immunol., 91, 416 (1963).PubMedGoogle Scholar
  6. 8.
    Melnick, J. L., S. E. Stinebaugh, and F. Rapp, J. Exptl. Med., 119, 313 (1964).CrossRefGoogle Scholar
  7. 9.
    Sabin, A. B., and M. A. Koch, these Proceedings, 50, 407 (1963).Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • F. Rapp
  • T. Kitahara
  • J. S. Butel
  • J. L. Melnick

There are no affiliations available

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