Cardiovascular Risk Assessment in Hypertension

  • William B. Kannel
Part of the Atlas of Heart Diseases book series (AD)


A number of modifiable cardiovascular risk factors have been shown to cluster with hypertension. These profoundly influence the hazard of hypertensive cardiovascular sequelae. The high-risk subgroup of hypertensive persons includes those who have one or more of the following: a high total-to-HDL (high-density lipoprotein) cholesterol ratio, impaired glucose tolerance, left ventricular hypertrophy (LVH), or the cigarette-smoking habit. The urgency for and choice of treatment should be guided by a multivariate risk assessment, taking into account these associated risk factors, as well as the character and severity of the blood pressure (BP) elevation.


Systolic Blood Pressure Left Ventricular Hypertrophy Ventricular Hypertrophy Framingham Study Multivariate Risk 
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  1. 1.
    Kannel WB: Epidemiology of essential hypertension: the Framingham experience. Proc R Coll Phys Edinb 1991, 21: 273–287.Google Scholar
  2. 2.
    Wilson PWF, Kannel WB: Hypertension, other risk factors and the risk of cardiovascular disease. In Hypertension: Pathophysiology, Diagnosis and Management. vol 1, edn 2. Edited by Laragh JH, Brenner BM. New York: Raven Press; 1995: 99–114.Google Scholar
  3. 3.
    Kannel WB, Dannenberg AL, Abbott RD: Unrecognized myocardial infarction and hypertension: the Framingham Study. Am Heart J 1985, 109: 581–585.PubMedCrossRefGoogle Scholar
  4. 4.
    Kannel WB: Potency of vascular risk factors as the basis for antihypertensive therapy. Eur Heart J 1992, 13(suppl G): 34–42.PubMedCrossRefGoogle Scholar
  5. 5.
    Kannel WB: Office assessment of coronary candidates. J Drug Dev 1992, 5: 49–58.Google Scholar
  6. 6.
    Kannel WB: Natural history of cardiovascular risk. In Atlas of Heart Diseases, vol 1, edn 1. Edited by Braunwald E, Hollenberg NK. Philadelphia: Current Medicine; 1994: 5.2–5.22.Google Scholar
  7. 7.
    Ashley Jr FW, Kannel WB: Relation of weight change to changes in atherogenic traits: the Framingham Study. J Chronic Dis 1974, 27: 103–114.PubMedCrossRefGoogle Scholar
  8. 8.
    Kannel WB, Cupples LA, Ramaswami R, et al.: Regional obesity and risk of cardiovascular disease: the Framingham Study. J Clin Epidemiol 1991, 44: 183–190.PubMedCrossRefGoogle Scholar
  9. 9.
    Kannel WB, Gordon T, Sorlie P, et al.: Physical activity and coronary vulnerability. Cardiol Dig 1971, 6: 28–40.Google Scholar
  10. 10.
    Kannel WB: High density lipoproteins: epidemiologic profile and risks of coronary artery disease. Am J Cardiol 1993, 52: 9B–13B.CrossRefGoogle Scholar
  11. 11.
    Kannel WB, D’Agostino RB, Belanger AJ: Update on fibrinogen as a cardiovascular risk factor. Ann Epidemiol 1992, 2: 457–466.PubMedCrossRefGoogle Scholar
  12. 12.
    Levy D, Solomon M, D’Agostino RB, et al.: Prognostic implications of baseline ECG features and their serial changes in subjects with left ventricular hypertrophy. Circulation 1994, 90: 1786–1793.PubMedCrossRefGoogle Scholar
  13. 13.
    Levy D, Garrison MS, Savage DD, et al.: Left ventricular mass and incidence of CHD in an elderly cohort. The Framingham Study. Ann Intern Med 1989, 110: 101–107.PubMedGoogle Scholar
  14. 14.
    Gillman MW, Kannel WB, Belanger AJ, D’Agostino RB: Influence of heart rate on mortality among persons with hypertension: the Framingham Study. Am Heart J 1993, 125: 1148–1154.PubMedCrossRefGoogle Scholar
  15. 15.
    Anderson KM, Wilson PWF, Odell P, et al.: An updated coronary risk profile: a statement for health professionals. Circulation 1991, 83: 356–362.PubMedCrossRefGoogle Scholar
  16. 16.
    Wolf PA, D’Agostino RB, Belanger AJ, et al.: Probability of a stroke: a risk factor from the Framingham Study. Stroke 1991, 22: 312–318.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2001

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  • William B. Kannel

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