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Pathogenesis of Hypertension: Genetic and Environmental Factors

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Atlas of Heart Diseases

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Abstract

Like obesity and diabetes, essential hypertension is one of the “diseases of civilization” that results from the collision of a modern lifestyle with Paleolithic genes.

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References

  1. Platt R: Heredity in hypertension. Q J Med 1947, 16: 111–113.

    PubMed  CAS  Google Scholar 

  2. Pickering GW: The genetic factor in essential hypertension. Ann Intern Med 1955, 43: 457–464.

    PubMed  CAS  Google Scholar 

  3. Ledingham JM: Genetics of human hypertension. In Hypertensive Cardiovascular Disease: Pathophysiology and Treatment. Edited by Amery A. The Hague/Boston/London: Martinus Nijhoff Publishers 1982: 206–216.

    Chapter  Google Scholar 

  4. Mongeau J-G, Brion P, Sing CF: The influence of genetics and household environment upon the variability of normal blood pressure: the Montreal Adoption Survey. Clin Exp Hypertens [A] 1986, 8: 653–660.

    Article  CAS  Google Scholar 

  5. Tambs K, Eaves LJ, Mourn T, et al.: Age-specific genetic effects for blood pressure. Hypertension 1993, 22: 789–795.

    Article  PubMed  CAS  Google Scholar 

  6. Ward R: Familial aggregation and genetic epidemiology of blood pressure. In Hypertension: Pathophysiology, Diagnosis, and Management. Edited by Laragh JH, Brenner BM. New York: Raven Press Ltd; 1990: 81–100.

    Google Scholar 

  7. Schork NJ, Jokelainen P, Grant EJ, et al.: Relationship of growth and blood pressure in inbred rats. Am J Physiol 1994, 266: R702–R708.

    PubMed  CAS  Google Scholar 

  8. St. Lezin E, Simonet L, Pravenec M, et al.: Hypertensive strains and normotensive “control” strains: how closely are they related? Hypertension 1992, 19: 419–424.

    Article  PubMed  CAS  Google Scholar 

  9. Bruner CA, Myers JH, Sing CF, et al.: Genetic association of hypertension and vascular changes in stroke-prone spontaneously hypertensive rats. Hypertension 1986, 8: 904–910.

    Article  PubMed  CAS  Google Scholar 

  10. Rapp JP: Characteristics of Dahl salt-susceptible and salt-resistant rats. In Handbook of Hypertension. Vol 4. Experimental and Genetic Models of Hypertension. Edited by de Jong W. New York: Elsevier Science Publishers; 1984: 286–295.

    Google Scholar 

  11. Harrap SB, Van Der Merwe WM, Griffin SA, et al.: Brief angiotensin-converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure long-term. Hypertension 1990, 16: 603–614.

    Article  PubMed  CAS  Google Scholar 

  12. Jacob HJ, Lindpaintner K, Lincoln SE, et al.: Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 1991, 67: 213–224.

    Article  PubMed  CAS  Google Scholar 

  13. Hilbert P, Lindpaintner K, Beckmann JS, et al.: Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 1991, 353: 521–529.

    Article  PubMed  CAS  Google Scholar 

  14. Rapp JP, Wang S-M, Dene H: A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science 1989, 243: 542–544.

    Article  PubMed  CAS  Google Scholar 

  15. St. Lezin EM, Pravenec M, Kurtz TW: New genetic models for hypertension research. Trends Cardiovasc Med 1993, 3: 119–123.

    Article  CAS  Google Scholar 

  16. Ely DL, Daneshvar H, Turner ME, et al.: The hypertensive Y chromosome elevates blood pressure in F11 normotensive rats. Hypertension 1993, 21: 1071–1075.

    Article  PubMed  CAS  Google Scholar 

  17. Ganten D, Lindpaintner K, Ganten U, et al.: Transgenic rats: new animal models in hypertension research. Hypertension 1991, 17: 843–855.

    Article  PubMed  CAS  Google Scholar 

  18. Mullins JJ, Peters J, Ganten D: Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 1990, 344: 541–544.

    Article  PubMed  CAS  Google Scholar 

  19. Williams RR, Hunt SC, Hasstedt SJ, et al.: Definition of genetic factors in hypertension: a search for major genes, polygenes, and homogeneous subtypes. J Cardiovasc Pharmacol 1988, 12(suppl 3): S7–S20.

    PubMed  Google Scholar 

  20. Lifton RP, Dluhy RG, Powers M, et al.: A chimaeric 11ß-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 1992, 355: 262–265.

    Article  PubMed  CAS  Google Scholar 

  21. White R, Lalouel J-M: Chromosomal mapping with DNA markers. Sci Am 1988, 258: 40–48.

    Article  PubMed  CAS  Google Scholar 

  22. Schuster H, Wienker TF, Bähring S, et al.: Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nat Genet, 1996; 13: 98–100.

    Article  PubMed  CAS  Google Scholar 

  23. Liddle GW, Bledsoe T, Coppage WS: Aldosteronism but with negligible aldosterone secretion. Trans Am Assoc Physiol 1963, 76: 199–213.

    CAS  Google Scholar 

  24. Botero-Velez M, Curtis JJ, Warnock DG: Brief report: Liddle’s syndrome revisited: a disorder of sodium resorption in the distal tubule. N Engl J Med 1994, 330: 178–181.

    Article  PubMed  CAS  Google Scholar 

  25. Shimkets RA, Warnock DG, Bositis CM, et al.: Liddle’s syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 1994, 79: 407–414.

    Article  PubMed  CAS  Google Scholar 

  26. Hansson JH, Nelson-Williams C, Suzuki H, et al.: Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 1995, 11: 76–82.

    Article  PubMed  CAS  Google Scholar 

  27. Hansson JH, Schild L, Lu Y, et al.: A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci USA 1995, 92: 11495–11499.

    Article  PubMed  CAS  Google Scholar 

  28. Schild L, Canessa CM, Shimkets RA, et al.: A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci USA 1995, 92: 5699–5703.

    Article  PubMed  CAS  Google Scholar 

  29. Lifton RP: Molecular genetics of human blood pressure variation. Science 1996, 272: 676–680.

    Article  PubMed  CAS  Google Scholar 

  30. Jeunemaitre X, Soubrier F, Kotelevtsev YV, et al.: Molecular basis of human hypertension: role of angiotensinogen. Cell 1992, 71: 1–20.

    Article  Google Scholar 

  31. Ward K, Hata A, Jeunemaitre X, et al.: A molecular variant of angiotensinogen associated with preeclampsia. Nature Genet 1993, 4: 59–61.

    Article  PubMed  CAS  Google Scholar 

  32. Inoue I, Nakajima T, Williams CS, et al.: A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 1997, 99: 1786–1797.

    Article  PubMed  CAS  Google Scholar 

  33. Casari G, Barlassina C, Cusi D, et al.: Association of the alpha-adducin locus with essential hypertension. Hypertension 1995, 25: 320–326.

    Article  PubMed  CAS  Google Scholar 

  34. Cusi D, Barlassina T, Azzani T, et al.: Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997, 349: 1353–1357.

    Article  PubMed  CAS  Google Scholar 

  35. Weder AB: Membrane sodium transport. In Hypertension Primer. The Essentials of High Blood Pressure. Edited by Izzo JL, Black HR. Dallas: American Heart Association; 1993: 36–37.

    Google Scholar 

  36. Blaustein M: Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. Am J Physiol 1977, 232: 065–073.

    Google Scholar 

  37. Haddy FJ: Potassium, Na+-K+ pump inhibitor and low-renin hypertension. Clin Invest Med 1987, 10: 547–554.

    PubMed  CAS  Google Scholar 

  38. Canessa ML, Adragna NC, Solomon HS, et al.: Increased lithium-sodium countertransport in red cells of patients with essential hypertension. N Engl J Med 1980, 302: 772–776.

    Article  PubMed  CAS  Google Scholar 

  39. Camussi A, Bianchi G: Genetics of essential hypertension: from the unimodal-bimodal controversy to molecular technology. Hypertension 1988, 12: 620–628.

    Article  PubMed  CAS  Google Scholar 

  40. Canessa ML, Morgan K, Semplicini A: Genetic differences in lithium-sodium exchange and regulation of the sodium-hydrogen exchanger in essential hypertension. J Cardiovasc Pharmacol 1988, 12(suppl 3): 92–98.

    Google Scholar 

  41. Weder AB: Red-cell lithium-sodium countertransport and renal lithium clearance in hypertension. N Engl J Med 1986, 314: 198–201.

    Article  PubMed  CAS  Google Scholar 

  42. Redgrave J, Canessa M, Gleason R, et al.: Red blood cell lithium-sodium countertransport in non-modulating essential hypertension. Hypertension 1989, 13: 721–726.

    Article  PubMed  CAS  Google Scholar 

  43. Doria A, Fioretto P, Avogaro A, et al.: Insulin resistance is associated with high sodium-lithium countertransport in essential hypertension. Am J Physiol 1991, 261: E684–E691.

    PubMed  CAS  Google Scholar 

  44. Lifton RP, Hunt SC, Williams RR, et al.: Exclusion of the Na+-H+ antiporter as a candidate gene in human essential hypertension. Hypertension 1991, 17: 8–14.

    Article  PubMed  CAS  Google Scholar 

  45. Julius S, Jamerson K, Meija A, et al.: The association of borderline hypertension with target organ changes and higher coronary risk: Tecumseh Blood Pressure Study. JAMA 1990, 264: 354–358.

    Article  PubMed  CAS  Google Scholar 

  46. Williams RR, Hunt SC, Hopkins PN, et al.: Familial dyslipidemic hypertension: evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension. JAMA 1988, 259: 3579–3586.

    Article  PubMed  CAS  Google Scholar 

  47. Williams RR, Hopkins PN, Hunt SC, et al.: Population-based frequency of dyslipidemic syndromes in coronary-prone families in Utah. Arch Intern Med 1990, 150: 582–588.

    Article  PubMed  CAS  Google Scholar 

  48. Wallin G, Kunimoto MM, Sellgren J: Possible genetic influence on the strength of human muscle nerve sympathetic activity at rest. Hypertension 1993, 22: 282–284.

    Article  PubMed  CAS  Google Scholar 

  49. Williams GH, Dluhy RG, Lifton RP, et al.: Non-modulation as an intermediate phenotype in essential hypertension. Hypertension 1992, 20: 788–796.

    Article  PubMed  CAS  Google Scholar 

  50. Rose G: Population distributions of risk and disease. Nutr Metab Cardiovasc Dis 1991, 1: 37–40.

    Google Scholar 

  51. INTERSALT Cooperative Research Group: INTERSALT: an international study of electrolyte excretion and blood pressure: results for 24 hour urinary sodium and potassium excretion. BMJ 1988, 297: 319–328.

    Article  Google Scholar 

  52. Rose G, Day S: The population mean predicts the number of deviant individuals. BMJ 1990, 301: 1031–1034.

    Article  PubMed  CAS  Google Scholar 

  53. Denton D, Weisinger R, Mundy NI, et al.: The effect of increased salt intake on blood pressure of chimpanzees. Nat Med 1995, 1: 1009–1016.

    Article  PubMed  CAS  Google Scholar 

  54. McCarron DA, Morris CD, Henry HJ, et al.: Blood pressure and nutrient intake in the United States. Science 1984, 224: 1392–1398.

    Article  PubMed  CAS  Google Scholar 

  55. Witteman JCM, Willett WC, Stampfer MJ, et al.: A prospective study of nutritional factors and hypertension among US women. Circulation 1989, 80: 1320–1327.

    Article  PubMed  CAS  Google Scholar 

  56. Resnick LM, Gupta RK, Bhargava KK: Cellular electrolytes in hypertension, diabetes, and obesity: a nuclear magnetic resonance spectroscopic study. Hypertension 1991, 17: 951–957.

    Article  PubMed  CAS  Google Scholar 

  57. Resnick LM: Calciotropic hormones in human and experimental hypertension. Am J Hypertens 1990, 3(suppl): 171–178.

    Google Scholar 

  58. Gruchow HW, Sobocinski KA, Barboriak JJ: Calcium intake and the relationship of dietary sodium and potassium to blood pressure. Am J Clin Nutr 1988, 48: 1463–1470.

    PubMed  CAS  Google Scholar 

  59. Criqui MH, Langer RD, Reed DM: Dietary alcohol, calcium, and potassium: independent and combined effects on blood pressure. Circulation 1989, 80: 609–614.

    Article  PubMed  CAS  Google Scholar 

  60. Green LW: Manual for scoring socioeconomic status for research on health behavior. Public Health Rep 1970, 85: 815–827.

    Article  PubMed  CAS  Google Scholar 

  61. Klag MJ, Whelton PK, Coresh J, et al.: The association of skin color with blood pressure in US blacks with low socioeconomic status. JAMA 1991, 265: 599–602.

    Article  PubMed  CAS  Google Scholar 

  62. Simopoulos AP: Dietary risk factors for hypertension. Comp Ther 1992, 18: 26–30.

    CAS  Google Scholar 

  63. Eaton SB, Konner M, Shostak M: Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective. Am J Med 1988, 84: 739–749.

    Article  PubMed  CAS  Google Scholar 

  64. Stamler J, Rose G, Elliott P, et al.: Findings of the international cooperative INTERSALT study. Hypertension 1991, 17(suppl I): 9–15.

    Article  Google Scholar 

  65. Wilson TW, Grim CE: Biohistory of slavery and blood pressure differences in blacks today: a hypothesis. Hypertension 1991, 17(suppl I): 122–128.

    Article  Google Scholar 

  66. Jackson FLC: An evolutionary perspective on salt, hypertension, and human genetic variability. Hypertension 1991, 17(suppl I): 129–132.

    Article  Google Scholar 

  67. Grobbee DE: Methodology of sodium sensitivity assessment: the example of age and sex. Hypertension 1991, 17(suppl I): 109–114.

    Article  Google Scholar 

  68. Grobbee DE, Hofman A: Does sodium restriction lower blood pressure? BMJ 1986, 293: 27–29.

    Article  PubMed  CAS  Google Scholar 

  69. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure: The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med 1993, 153: 154–183.

    Article  Google Scholar 

  70. Midgley JP, Matthew AG, Greenwood CMT, Logan AG: Effect of reduced dietary sodium on blood pressure: a meta-analysis of randomized controlled trials. JAMA 1996, 275: 1590–1597.

    Article  PubMed  CAS  Google Scholar 

  71. Hollenberg NK, Martinez G, McCullough M, et al.: Aging, acculturation, salt intake, and hypertension in the Kuna of Panama. Hypertension 1997, 171–176.

    Google Scholar 

  72. Krishna GG, Miller E, Kapoor S: Increased blood pressure during potassium depletion in normotensive men. N Engl J Med 1989, 320: 1177–1182.

    Article  PubMed  CAS  Google Scholar 

  73. Appel LJ, Moore TJ, Obarzanek E, et al.: A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 1997, 336: 1117–1124.

    Article  PubMed  CAS  Google Scholar 

  74. Grobbee DE, Waal-Manning HJ: The role of calcium supplementation in the treatment of hypertension: current evidence. Drugs 1990, 39: 7–18.

    Article  PubMed  CAS  Google Scholar 

  75. Barker DJP, Bull AR, Osmund C, et al.: Fetal and placental size and risk of hypertension in adult life. BMJ 1990, 301: 259–262.

    Article  PubMed  CAS  Google Scholar 

  76. Whincup PH, Cook DG, Shaper AG: Early influences on blood pressure: a study of children aged 5–7 years. BMJ 1989, 299: 587–591.

    Article  PubMed  CAS  Google Scholar 

  77. Lauer RM, Anderson AR, Beaglehole R, et al.: Factors related to tracking of blood pressure in children: U.S. National Center for Health Statistics Health Examination Surveys Cycles II and III. Hypertension 1984, 6: 307–314.

    Article  PubMed  CAS  Google Scholar 

  78. Krieger DR, Landsberg L: Obesity and hypertension. In Hypertension: Pathophysiology, Diagnosis, and Management. Edited by Laragh JH, Brenner BM. New York: Raven Press, Ltd; 1990: 1741–1757.

    Google Scholar 

  79. Kaplan NM: The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989, 149: 1514–1520.

    Article  PubMed  CAS  Google Scholar 

  80. Rocchini AP, Key J, Bondie D, et al.: The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. N Engl J Med 1989, 321: 580–585.

    Article  PubMed  CAS  Google Scholar 

  81. Stevens VJ, Corrigan SA, Obarzanek E, et al.: Weight loss intervention in phase 1 of the Trials of Hypertension Prevention. Arch Intern Med 1993, 153: 849–858.

    Article  PubMed  CAS  Google Scholar 

  82. Light KC, Koepke JP, Obrist PA, et al.: Psychological stress induces sodium and fluid retention in men at high risk for hypertension. Science 1983, 220: 429–431.

    Article  PubMed  CAS  Google Scholar 

  83. Evans WE, Relling MV: Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999, 286: 487–491.

    Article  PubMed  CAS  Google Scholar 

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Weder, A.B. (2001). Pathogenesis of Hypertension: Genetic and Environmental Factors. In: Hollenberg, N.K. (eds) Atlas of Heart Diseases. Atlas of Heart Diseases. Current Medicine Group, London. https://doi.org/10.1007/978-1-4684-6909-7_1

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  • DOI: https://doi.org/10.1007/978-1-4684-6909-7_1

  • Publisher Name: Current Medicine Group, London

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