St. Jude Medical® Cardiac Valve Experience in Infants and Children

  • D. N. Campbell
  • C. Madigan
  • D. R. Clarke


During the last 7 years, 44 ST. JUDE MEDICAL® cardiac valves have been placed in 43 children. Nine patients were less than 1 year of age and 1 child had a double valve replacement. Twenty-four valves were placed in the aortic position. Seven of these patients underwent valve replacement only, while 16 patients had concomitant aortoventriculoplasties, and 1 patient had a Manouguian procedure. There were 2 early and no late deaths. Both deaths occurred in critically ill children who underwent emergency operations. Twenty valves were placed in the mitral position (12 annular and 8 supra-annular). There were no deaths with annular replacements and 7 deaths (2 early and 5 late) when supra-annular placement was used. Four of the 5 late deaths had marked preoperative left ventricular dysfunction. Mean patient follow-up is 43 months in 34 long-term survivors. Anticoagulation was achieved with warfarin, often in combination with sulfinpyrazone or dipyridamole. There have been 3 episodes of thromboembolism, all occurring in patients with suboptimal anticoagulation. We conclude that: 1) results from ST. JUDE MEDICAL cardiac valve replacement in the aortic position or in the mitral position with annular placement in children are excellent, 2) anticoagulation with warfarin is warranted, and 3) morbidity and mortality are often related to the underlying disease (mitral annular hypoplasia or left ventricular dysfunction) rather than to valve malfunction or technical problems at operation.


Aortic Valve Valve Replacement Aortic Valve Replacement Mitral Valve Replacement Heart Valve Replacement 


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  1. 1.
    Dunn JM. Porcine valve durability in children. Ann Thorac Surg 1981; 32:357–368.PubMedCrossRefGoogle Scholar
  2. 2.
    Walker WE, Duncan JM, Frazier OH Jr, Livesay JJ, Ott DA, Reul GJ, Cooley DA. Early experience with the Ionescu-Shiley pericardial xenograft valve. Accelerated calcification in children. J Thorac Cardiovasc Surg 1983; 86:570–575.PubMedGoogle Scholar
  3. 3.
    Williams DB, Danielson GK, McGoon DC, Puga FJ, Mair DD, Edwards WD. Porcine heterograft valve replacement in children. J Thorac Cardiovasc Surg 1982; 84:446–450.PubMedGoogle Scholar
  4. 4.
    Sanders SP, Levy RJ, Freed MD, Norwood WI, Castaneda AR. Use of Hancock porcine xenografts in children and adolescents. Am J Cardiol 1980; 46:429–438.PubMedCrossRefGoogle Scholar
  5. 5.
    Schaffer MS, Campbell DN, Clarke DR, Wiggins JWJr, Wolfe RR. Aortoventriculoplasty in children. J Thorac Cardiovasc Surg 1986; 92:391–395.PubMedGoogle Scholar
  6. 6.
    Pass HI, Sade RM, Crawford FA, Hohn AR. Cardiac valve prostheses in children without anticoagulation. J Thorac Cardiovasc Surg 1984; 87:832–835.PubMedGoogle Scholar
  7. 7.
    Verrier ED, Tranbaugh RF, Soifer SJ, Yee ES, Turley K, Ebert PA. Aspirin anticoagulation in children with mechanical aortic valves. J Thorac Cardiovasc Surg 1986; 92:1013–1020.PubMedGoogle Scholar
  8. 8.
    Bradley LM, Midgley FM, Watson DC, Getson PR, Scott LP III. Anticoagulation therapy in children with mechanical prosthetic cardiac valves. Am J Cardiol 1985; 56:533–535.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • D. N. Campbell
  • C. Madigan
  • D. R. Clarke

There are no affiliations available

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