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PPAR: a Key Nuclear Factor in Nutrient / Gene Interactions?

  • Béatrice Desvergne
  • Walter Wahli
Part of the Progress in Gene Expression book series (PRGE)

Abstract

Retinoids as well as steroid and thyroid hormones are small lipophilic molecules that exert an intricate array of combinatorial effects during embryogenesis, cellular differentiation, and homeostasis in the adult organism. Complexity in the signalling pathway of these hormones results from the functional association of low affinity cytoplasmic hormone binding proteins and high affinity nuclear hormone receptors. The latter interact with polymorphic response elements linked to target genes and mediate the hormonal response at the transcriptional level.

Keywords

Retinoic Acid Receptor Peroxisome Proliferators Estrogen Response Element Hypolipidemic Drug Hormone Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Auwerx J (1992): Regulation of gene expression by fatty acids and fibric acid derivatives: An integrative role for peroxisome proliferator activated receptors. Horm Res 38: 269–277PubMedGoogle Scholar
  2. Baes M, Castelein H, Declercq PE (1994): The malic enzyme promoter contains multiple recognition sites for nuclear hormone receptors. J Cell Biochem 18B: 361Google Scholar
  3. Bardot O, Aldridge TC, Latruffe N, Green S (1993): PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the afunctional enzyme gene. Biochem Biophys Res Commun 192: 37–45PubMedGoogle Scholar
  4. Beck F, Plummer S, Senior PV, Byrne S, Green S, Brammar WJ (1992): The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat. Proc Royal Soc Lond [Biol] 247: 83–87Google Scholar
  5. Braissant O, Wahli W (1994): unpublished observationGoogle Scholar
  6. Caldwell J (1984): Xenobiotic acyl-coenzymes A critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids. Biochem Society Trans 12:9–11Google Scholar
  7. Cannon JR, Eacho PI (1991): Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver. Biochem J 280: 387–391PubMedGoogle Scholar
  8. Chawla A, Lazar MA (1994): Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc Natl Acad Sci USA 91: 1786–1790PubMedGoogle Scholar
  9. Chen F, Law SN, O’Malley BW (1993): Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Comm 196: 671–677PubMedGoogle Scholar
  10. Ciolek E, Dauça M (1991): The effect of Clofibrate on amphibian hepatic peroxisomes. Biol Cell 71: 313–320PubMedGoogle Scholar
  11. Cooney AJ, Leng XH, Tsai SY, O’Malley BW, Tsai MJ (1993): Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin-D, thyroid hormone, and retinoic acid receptors. J Biol Chem 268: 4152–4160PubMedGoogle Scholar
  12. Cooney AJ, Tsai SY, O’Malley BW, Tsai MJ (1992): Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the Vitamin-D(3), Thyroid hormone, and Retinoic acid receptors. Mol Cell Biol 12: 4153–4163PubMedGoogle Scholar
  13. Dayton AI, Seiden JR, Laws G, Dorney DJ, Finan J, Tripputi P, Emanuel BS, Roveera G, Nowell PC, Croce C (1984): A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia. Proc Natl Acad Sci USA 81: 4495–4499PubMedGoogle Scholar
  14. Desvergne B (1994): How do thyroid hormone receptors bind to structurally diverse response elements? Mol Cell Endocrinol: 100: 125–131PubMedGoogle Scholar
  15. Dingwall C, Laskey RA (1991): Nuclear Targeting Sequences — A Consensus. Trends Biochem Sci 16: 478–181PubMedGoogle Scholar
  16. Drabkin H, Kao F-T, Hartz J, Hart I, Gazdar A, Weinberger C, Evans R, Gerber M (1988): Localization of human ERBA2 to the 3p22–3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer. Proc Natl Acad Sci USA 85: 9258–9262PubMedGoogle Scholar
  17. Dreyer C, Keller H, Mahfoudi A, Laudet V, Krey G, Wahli W(1993): Positive regulation of the peroxisomal -oxidation pathway by fatty acids through activation of peroxisome proliferator activated receptors (PPAR). Biol Cell 77: 67–76Google Scholar
  18. Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W (1992): Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68: 879–887PubMedGoogle Scholar
  19. Eacho PI, Foxworthy PS, Herron DK (1993): Tetrazole substituted acetophenone peroxisome proliferators: structure-activity relationships and effects on hepatic lipid metabolism. In: Peroxisomes: Biology and Importance in Toxicology and Medicine, Gibson G, Lake B, eds. London: Taylor & FrancisGoogle Scholar
  20. Ellinger-Ziegelbauer H, Hihi AK, Laudet V, Keller H, Wahli W, Dreyer C (1994): FTZ-F1-related orphan receptors in Xenopus laevis transcriptional regulators differentially expressed during early embryogenesis. Mol Cell Biol 14:2786–2797PubMedGoogle Scholar
  21. Feller DR, Intrasuksri U (1993): Structural requirements for peroxisome proliferation by phenoxyacetic and fatty acid analogues in primary cultures of rat hepatocytes. In: Peroxisomes: Biology and Importance in Toxicology and Medicine, Gibson G, Lake B, eds. London: Taylor & FrancisGoogle Scholar
  22. Fiatmark T, Christiansen EN (1993): Modulation of peroxisomal biogenesis and lipid metabolizing enzymes by dietary factors. In: Peroxisomes: Biology and Importance in Toxicology and Medicine, Gibson G, Lake B eds. London: Taylor & FrancisGoogle Scholar
  23. Fiatmark T, Christiansen EN, Kryvi H (1983): Evidence for a negative modulating effect of erucic acid on the peroxisomal beta-oxidation enzyme system and biogenesis in rat liver. Biochem Biophys Acta 753: 460–466Google Scholar
  24. Flatmark T, Nilsson A, Krames J, Eikhom T-S, Fukami MH, Kryvi H, Christiansen EN (1988): On the mechanism of induction of the enzyme systems for peroxisomal ß-oxidation of fatty acids in rat liver by diets rich in partially hydro-genated fish oil. Biochem Biophys Acta 962: 122–130PubMedGoogle Scholar
  25. Forman BM, Samuels HH (1990): Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Mol Endocrinol 4: 1293–1301PubMedGoogle Scholar
  26. Forman BM, Yang C-R, Au M, Casanova J, Ghysdael J, Samuels HH (1989): A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors. Mol Endocrinol 3: 1610–1626PubMedGoogle Scholar
  27. Gearing KL, Crickmore A, Gustafsson JA (1994): Structure of the mouse peroxisome proliferator activated receptor a gene. Biochem Biophysic Res Comm 199: 255 – 263Google Scholar
  28. Gearing KL, Göttlicher M, Teboul M, Widmark E, Gustafsson JA (1993): Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc Natl Acad Sci USA 90: 1440–1444PubMedGoogle Scholar
  29. Girard J, Perdereau D, Foufelle F, Prip-Buus C, Ferré P (1994): Regulation of lipogenic enzyme expression by nutrients and hormones. FASEB J 8: 36–42PubMedGoogle Scholar
  30. Göttlicher ME, Widmark E, Li Q, Gustafsson JA (1992): Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci USA 89: 4653–4657PubMedGoogle Scholar
  31. Green S (1992): Receptor-mediated mechanisms of peroxisome proliferators. Biochem Pharmacol 43: 393–401PubMedGoogle Scholar
  32. Green S, Wahli W (1994): Peroxisome proliferator activated receptors: finding the orphan a home. Mol Cell Endocrinol 100: 149–153PubMedGoogle Scholar
  33. Greene ME, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K, Hsieh L, Greene GL, Nimer SD (1994): personal communicationGoogle Scholar
  34. Gronemeyer H (1992): Control of transcription activation by steroid hormone receptors. FASEB J 6: 2524–2529PubMedGoogle Scholar
  35. Grundy SM, Ahrens EH, Sälen G, Nestel SPH, Nestel PJ (1972): Mechanisms of action of Clofibrate on cholesterol metabolism in patients with hyperlipidemia. J Lipid Res 13: 531–551PubMedGoogle Scholar
  36. Hashizume K, Miyamoto T, Ichikawa K, Sakurai A, Ohtsuka H, Kobayashi M, Nishii Y, Yamada T (1989): Evidence for the presence of two active forms of cytosolic 3,5,3’-triiodo-L-thyronine (T3)-binding protein (CTBP) in rat kidney. J Biol Chem 264: 4864–4871PubMedGoogle Scholar
  37. Havel RJ, Kane JP (1973): Drugs and lipid metabolism. Annu Rev Pharmacol 13: 287–308PubMedGoogle Scholar
  38. Hertz R, Bar-Tana J (1992): Induction of peroxisomal beta-oxidation genes by retinoic acid in cultured rat hepatocytes. Biochem J 281: 41–43PubMedGoogle Scholar
  39. Hertz R, Aurbach R, Hashimoto T, Bar-Tana J (1991): Thyromimetic effect of peroxisomal proliferators in rat liver. Biochem J 21 A: 745–751Google Scholar
  40. Hess R, Staubli W, Reiss W (1965): Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature 208: 856–859PubMedGoogle Scholar
  41. Hirst MA, Hinck L, Danielsen M, Ringold GM (1992): Discrimination of DNA response elements for thyroid hormone and estrogen is dependent on dimerization of receptor DNA binding domains. Proc Natl Acad Sci USA 89: 5527–5531PubMedGoogle Scholar
  42. Hori S, Ishii H, Suga T (1981): Changes in peroxisomal fatty acid oxidation in diabetic rat liver.J Biochem 90: 1691–1696Google Scholar
  43. IJpenburg A, Desvergne B, Wahli W (1994): unpublished observationGoogle Scholar
  44. Issemann I, Green S (1990): Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645–650PubMedGoogle Scholar
  45. Issemann I, Prince RA, Tugwood JD, Green S (1992): A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation? Biochem Soc Trans 20: 824–827PubMedGoogle Scholar
  46. Issemann I, Prince RA, Tugwood JD, Green S (1993): The peroxisome proliferator activated receptor: retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidemic drugs. J Molec Endocrinol 11: 37–47Google Scholar
  47. Jones TA, Bergfors T, Sedzik J, Unge T (1988):The three-dimensional structure of P2 myelin protein. EMBO J 7: 1597–1604PubMedGoogle Scholar
  48. Kaikaus RM, Chan WK, Lysenko N, Ray R, De Montellano PRO, Bass NM (1993): Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators — mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway. J Biol Chem 268: 9593–9603PubMedGoogle Scholar
  49. Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W (1993a): Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci USA 90: 2160–2164PubMedGoogle Scholar
  50. Keller H, Mahfoudi A, Dreyer C, Hihi AK, Medin J, Ozato K, Wahli W (1993b): Peroxisome proliferator activated receptors and lipid metabolism. Ann NY Acad Sci 684: 157–173PubMedGoogle Scholar
  51. Keller H, Wahli W (1994): unpublished observationGoogle Scholar
  52. Keller H, Wahli W (1993): Peroxisome proliferator-activated receptors: A link between endocrinology and nutrition? Trends Endocrinol Metab 4: 291–296PubMedGoogle Scholar
  53. Keese PK, Gibbs A (1992): Origins of genes: ‘Big bang’ or continuous creation? Proc Natl Acad Sci USA 89: 9489–9493PubMedGoogle Scholar
  54. Khan SH, Sorof S (1994): Liver fatty acid-binding protein: specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators. Proc Natl Acad Sci USA 91: 848–852PubMedGoogle Scholar
  55. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM (1992): Convergence of 9-Cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358:771–774PubMedGoogle Scholar
  56. Knoll AH (1992): The early evolution of eukaryotes — a geological perspective. Science 256: 622–627PubMedGoogle Scholar
  57. Krey G, Keller H, Mahfoudi A, Medin J, Ozato K, Dreyer C, Wahli W (1993): Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with RXR and activation by fatty acids. J Steroid Biochem Mol Biol 47: 65–73PubMedGoogle Scholar
  58. Krey G, Keller H, Mahfoudi A, Wahli W (1994a): PPARs: nuclear hormone receptors controlling peroxisomal fatty acid β-oxidation. In: Peroxisomal Disorders in Relation to Functions and Biogenesis of Peroxisomes, Wansers RJA, Schutgens RBH, Tabak HF, eds. Amsterdam: Elsevier Science bvGoogle Scholar
  59. Krey G, Mahfoudi A, Wahli W (1994b): unpublished observationGoogle Scholar
  60. Lake BG, Lewis DFV (1993): Structure-activity relationships for chemically induced peroxisome proliferation in mammalian liver. In: Peroxisomes: Biology and Importance in Toxicology and Medicine, Gibson G, Lake B, eds. London: Taylor & FrancisGoogle Scholar
  61. Lalwani ND, Fahl WE, Reddy JK (1983): Detection of a nafenopin-binding protein in a rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds. Biochem Biophys Res Commun 116: 389–393Google Scholar
  62. Latruffe N, Bugaut M, Bournot P, Benteja M, Ramirez LC, Cherakaoui Malki M (1993): Molecular basis of gene regulation by peroxisome proliferators. In: Peroxisomes: Biology and Importance in Toxicology and Medicine, Gibson G, Lake B, eds. London: Taylor & FrancisGoogle Scholar
  63. Laudet V, Begue A, Henryduthoit C, Joubel A, Martin P, Stehelin D, Saule S (1991): Genomic organization of the human thyroid hormone receptor-alpha (c-erbA-1) gene. Nucleic Acids Res 19: 1105–1112PubMedGoogle Scholar
  64. Laudet V, Hanni C, Coll J, Catzeflis F, Stehelin D (1992): Evolution of the nuclear receptor gene superfamily. EMBO J 11: 1003–1013 Lazar MA, Hodin RA, Darling DS, Chin WW (1989): A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbAα transcriptional unit. Mol Cell Biol 9: 1128–1136Google Scholar
  65. Lazarow P, deDuve C (1976): A fatty acyl-CoA oxidizing system in the rat liver peroxisomes: enhancement by Clofibrate, a hypolipidemic drug. Proc Natl Acad Sci USA 73: 2042–2046Google Scholar
  66. Lee MS, Kliewer SA, Provencal J, Wright PE, Evans RM (1993): Structure of the retinoid X receptor a DNA binding domain: A helix required for homodimeric DNA binding. Science 260: 1117–1121PubMedGoogle Scholar
  67. Lehmann JM, Hoffmann B, Pfahl M (1991): Genomic organization of the retinoic acid receptor gamma-gene. Nucleic Acids Res 19: 573–578PubMedGoogle Scholar
  68. Leid M, Kastner P, Chambon P (1992): Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem Sci 17: 427–433PubMedGoogle Scholar
  69. Lock EA, Mitchell AM, Elcombe CR (1989): Biochemical mechanisms of induction of hepatic peroxisome proliferation. Ann Rev Pharmacol Toxicol 29: 145–163Google Scholar
  70. Luisi BV, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB (1991): Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352: 497–505PubMedGoogle Scholar
  71. Mader S, Kumar V, de Verneuil H, Chambon P (1989): Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element. Nature 338: 271–274PubMedGoogle Scholar
  72. Mannaerts GP, Van Veldhoven PP (1993): Role of peroxisomes in mammalian metabolism. In: Peroxisomes: Biology and Importance in Toxicology and Medicine, Gibson G, Lake B, eds London: Taylor & FrancisGoogle Scholar
  73. Marsman DS, Cattley RC, Conway JG, Popp JA (1988): Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethyl-hexil)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy 14,643) in rats. Cancer Res 48: 6739–6744PubMedGoogle Scholar
  74. Martinez E, Wahli W (1991): Characterization of hormone response elements. In: Nuclear Hormone Receptors, Parker MG, ed. London: Harcourt Brace JovanovitchGoogle Scholar
  75. Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennstrom B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P (1991): Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat gnomes. Genomics 10: 1061–1069PubMedGoogle Scholar
  76. Miyajima NR, Horiuchi R, Shibuya Y, Fukushige SI, Matsubara KI, Toyoshima K, Yamamoto T (1989): Two erbA-homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57: 31–39PubMedGoogle Scholar
  77. Miyata KS, Zhang B, Marcus SL, Capone JP, Rachubinski RA (1993): Chicken Ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome prolif-erator-mediated signaling. J Biol Chem 268: 19169–19172PubMedGoogle Scholar
  78. Motojiama K, Goto S, Imanaka T (1992): Specific repression of transthyrethin gene expression in rat liver by a peroxisome proliferator Clofibrate. Biochem Biophys Res Comm 188: 799–806Google Scholar
  79. Muerhoff AS, Griffin KJ, Johnson EF (1992): The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome-P450 fatty-acid omega-hydroxylase, by clofibric acid. J Biol Chem 267: 19051–19053PubMedGoogle Scholar
  80. Neat CE, Thomassen S, Osmundsen H (1980): Induction of peroxisomal β-oxidation in rat liver by high-fat diets. Biochem J 186: 369–371PubMedGoogle Scholar
  81. Nemali MR, Reddy MK, Usuda N, Reddy PG, Comeau LD, Rao MS, Reddy JK (1989): Differential induction and regulation of peroxisomal enzymes: predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens. Toxicol Appl Pharmacol 97: 72–87PubMedGoogle Scholar
  82. Nesel PJ (1990): Effects of n-3 fatty acids on lipid metabolism. Annu Rev Nutr 10:149–167Google Scholar
  83. Norum KR, Christiansen EN, Christopherson BO, Bremer J (1989): Metabolic and nutritional aspects of long chain fatty acids of marine origin. In: The Role of Fat in Human Nutrition, Vergroesen AJ, Crawford M, eds. London: Academic PressGoogle Scholar
  84. Orellana M, Fuentes O, Rosenbluth H, Lara M, Valdez E (1992): Modulation of rat liver peroxisomal and microsomal fatty acid oxidation by starvation. FEBS Letters 310:193–196PubMedGoogle Scholar
  85. Orton TC, Adam HK, Bentley M, Holloway B, Tucker MJ (1984): Species differences in the morphological response of the liver following chronic Clofibrate administration. Toxicol Appl Pharmacol 73: 138–151PubMedGoogle Scholar
  86. Osmundsen H, Bremer J, Pedersen JI (1991): Metabolic aspects of peroxisomal beta-oxidation. Biochim Biophys Acta 1085: 141–158PubMedGoogle Scholar
  87. Osumi T, Wen JK, Hashimoto T (1991): Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene. Biochem Biophys Res Commun 175: 866–871PubMedGoogle Scholar
  88. Parker MG (1993): Steroid and related receptors. Current Opinion in Cellular Biology 5: 499–504Google Scholar
  89. Rao MS, Reddy JK (1987): Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis 8: 631–636PubMedGoogle Scholar
  90. Reddy JK, Lalwani ND (1983): Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit Rev Toxicol 12: 1–58Google Scholar
  91. Ritchie HH, Wang L-H, Tsai S, O’Malley BW, Tsai MJ (1990): COUP-TF gene: a structure unique for the steroi/thyroid receptor family. Nucleic Acids Res 18: 6857–6862PubMedGoogle Scholar
  92. Rodriguez JC, Gil-Gomez G, Hegardt FG, Haro D (1994): The peroxisome proliferator-activated receptor mediates the induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J Biol Chem in pressGoogle Scholar
  93. Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA (1992): Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 6: 1634–1641PubMedGoogle Scholar
  94. Schoonjans K, Auwerx J (1994): personal communicationGoogle Scholar
  95. Segraves WA, Hogness DS (1990): The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily. Genes & Dev 4: 204–219Google Scholar
  96. Sher T, Yi HF, Mcbride OW, Gonzalez FJ (1993): cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32: 5598–5604Google Scholar
  97. Shi Y-B, Yaoita Y, Brown DD (1992): Genomic organization and alternative promoter usage of the two thyroid hormone receptor β genes in Xenopus-laevis. J Biol Chem 267: 733–738PubMedGoogle Scholar
  98. Sitori CR, Catapano A, Proletti R (1977): Therapeutic significance of hypolipidemic and antiatherosclerotic drugs. Atherosclerosis Rev 2: 113–153Google Scholar
  99. Small GM (1993): Peroxisome biogenesis. In: Peroxisomes: Biology and Importance in Toxicology and Medicine, Gibson G, Lake B, eds. London: Taylor & FrancisGoogle Scholar
  100. Sodhi, HS, Kudchodkar BJ, Horlick L, Weder CH (1971): Effects of chlorophenox-yisobutyrate on the synthesis and metabolism on cholesterol in man. Metabolism 20: 348–359PubMedGoogle Scholar
  101. Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, Green S (1992): The mouse peroxisome proliferator activated receptor recognizes a response element in the 5’ flanking sequence of the rat acyl CoA oxidase gene. EMBO J 11: 433–439PubMedGoogle Scholar
  102. Umesono K, Evans RM (1989): Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57: 1139–1146PubMedGoogle Scholar
  103. Vaulont S, Kahn A (1994): Transcriptional control of metabolic genes by carbohydrates. FASEB J 8: 28–35PubMedGoogle Scholar
  104. Wahli W, Martinez E (1991): Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression. FASEB J 5: 2243–2249PubMedGoogle Scholar
  105. Wilson TE, Fahrner TJ, Johnston M, Milbrandt J (1991): Identification of the DNA binding site for NGF1-B by genetic selection in yeast. Science 252: 1296–1300PubMedGoogle Scholar
  106. Wilson TE, Paulsen RE, Padgett KA, Milbrandt J (1992): Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Science 256: 107–110PubMedGoogle Scholar
  107. Ylikomi T, Bocquel MT, Berry M, Gronemeyer H, Chambon P (1992): Cooperation of protosignals for nuclear accumulation of estrogen and progesterone receptors. EMBO J 11: 3681–3694PubMedGoogle Scholar
  108. Zhang BW, Marcus SL, Sajjadi FG, Alvares K, Reddy JK, Subramani S, Rachubinski RA, Capone JP (1992): Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal Enoyl-CoA Hydratase/3-Hydroxyacyl-CoA Dehydrogenase. Proc Natl Acad Sci USA 89: 7541–7545PubMedGoogle Scholar
  109. Zhang X-k, Hoffman B, V Tran P-B, Graupner G, Pfahl M (1992): Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature 355: 442–446Google Scholar
  110. Zhang X-k, Pfahl M (1993): Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors. Trends Endocrinol Metab 4: 156–162PubMedGoogle Scholar
  111. Zhu Y, Alvars K, Huang Q, Rao MS, Reddy JK (1993): Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J Biol Chem 258: 26817–26820Google Scholar

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© Birkhäuser Boston 1995

Authors and Affiliations

  • Béatrice Desvergne
  • Walter Wahli

There are no affiliations available

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