NF-κB: A Mediator of Pathogen and Stress Responses

  • Ulrich Siebenlist
  • Keith Brown
  • Guido Franzoso
Part of the Progress in Gene Expression book series (PRGE)

Abstract

The transcription factor NF-κB is a central regulator of defensive responses which are mounted by cells against many potentially threatening environmental challenges. Bacteria, viruses, parasites, injury, radiation, oxidative stress, numerous chemical agents and many cytokines released in response to such challenges are all well-studied and potent activators of this transcription factor in a number of different cell types. Activated NF-κB then induces the expression of many genes whose encoded functions play critical roles for the defense of the organism. The induced proteins have a wide range of activities, including antibacterial or anti-viral functions, antigen recognition, cellular migration and adhesion as well as hematopoietic cell differentiation and proliferation. Aside from regulating cellular genes, several viruses, including the human immunodeficiency virus, have diverted this factor for their own purposes. Since many cytokines are regulated by NF-κB, this transcription factor appears critical to a coordinated defense response. In an evolutionary sense, the association between defensive responses and NF-κB dates at least as far back as insects.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Type Chicken Embryo Fibroblast Ankyrin Domain Bours Versus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Boston 1995

Authors and Affiliations

  • Ulrich Siebenlist
  • Keith Brown
  • Guido Franzoso

There are no affiliations available

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