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The Heat Shock Transcriptional Response

  • Paul E. Kroeger
  • Richard I. Morimoto
Part of the Progress in Gene Expression book series (PRGE)

Abstract

The heat shock response represents one of the most dramatic changes in gene expression and has served as a paradigm for inducible transcriptional responses. The response to temperature elevation, exposure to toxic agents, or other physiological stresses is universal and mediated through the induction of a highly conserved set of genes referred to as heat shock (HS) genes (Lindquist, 1986; Lindquist and Craig, 1988; Morimoto and Milarski, 1990; Morimoto, 1993; Morimoto et al, 1994). Studies in the early 1970’s had revealed that the elevation of temperature induces the synthesis of new polypeptides. It had been recognized early that these newly synthesized HS proteins (HSPs) are important to the survival response mounted by the cell. Perhaps the most significant effect of HS is on transcription. As the severity of the HS increases, the transcription of most genes is repressed and the genes coding for HSPs are transcriptionally induced 50 to 100-fold within minutes. HS has additional effects on mRNA stability and translational control which contribute to the preferential expression of HSPs (Lindquist, 1980; Storti et al, 1980; Banerji et al, 1984; Lindquist and Craig, 1988).

Keywords

Heat Shock HSP70 Gene Heat Shock Response Heat Shock Factor Heat Shock Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abravaya K, Myers MP, Murphy SP, Morimoto RI (1992): The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene transcriptions. Genes & Dev 6: 1153–1164Google Scholar
  2. Abravaya K, Phillips B, Morimoto RI (1991a): Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Mol Cell Biol 11: 586–592PubMedGoogle Scholar
  3. Abravaya K, Phillips B, Morimoto RI (1991b): Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes & Dev 5: 2117–2127Google Scholar
  4. Agoff SN, Hou J, Linzer DI, Wu B (1993): Regulation of the human hsp70 promoter by p53. Science 259: 84–87PubMedGoogle Scholar
  5. Amici C, Sistonen L, Santoro MG, Morimoto RI (1992): Anti-proliferative prostaglandins activate heat shock transcription factor. Proc Natl Acad Sci USA 89: 6227–6231PubMedGoogle Scholar
  6. Amin J, Ananthan J, Voellmy R (1988): Key features of heat shock regulatory elements. Mol Cell Biol 8: 3761–3769PubMedGoogle Scholar
  7. Anathan T, Goldberg AL, Voellmy R (1986): Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes. Science 232: 522–524Google Scholar
  8. Aoki M, Abe K, Kawagoe JI, Sato S, Nakamura S, Kogure K (1993): Temporal profile of the induction of heat shock protein 70 and heat shock cognate protein 70 mRNAs after transient ischemia in gerbil brain. Brain Res 601: 185–192PubMedGoogle Scholar
  9. Ashburner M (1970): Pattern of puffing activity in the salivary gland chromosomes of Drosophila. V. Response to environmental treatments. Chromosorna 31: 356–376Google Scholar
  10. Baler R, Welch WJ, Voellmy R (1992): Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor. J Cell Biol 117: 1151–1159PubMedGoogle Scholar
  11. Banerji SS, Theordorakis NG, Morimoto RI (1984): Heat-shock-induced translational control of hsp70 and globin synthesis in chicken reticulocytes. Mol Cell Biol 4: 2437–2448PubMedGoogle Scholar
  12. Becker PB, Rabindran SK, Wu C (1991): Heat shock-regulated transcription in vitro from a reconstituted chromatin template. Proc Natl Acad Sci USA 88: 4109–4113PubMedGoogle Scholar
  13. Beckmann RP, Mizzen LE, Welch WJ (1990): Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science 248: 850–854PubMedGoogle Scholar
  14. Benjamin IJ, Kroger B, Williams RS (1992): Induction of stress proteins in cultured myogenic cells: Molecular signals for the activation of heat shock transcription factor during ischemia. J Clin Invest 89: 1658–1689Google Scholar
  15. Bienz M, Pelham HRB (1986): Heat shock regulatory elements function as an inducible enhancer in the Xenopus hsp70 gene and when linked to a heterologous promoter. Cell 45: 753–760PubMedGoogle Scholar
  16. Blackwell TK, Weintraub H (1990): Differences and similarities in DNA-binding preferences of myoD and E2A protein complexes revealed by binding site selection. Science 250: 1104–1110PubMedGoogle Scholar
  17. Blake MJ, Gershon D, Fargnoli J, Holbrook NJ (1990a): Discordant expression of heat shock protein mRNAs in tissues of heat-stressed rats. J Biol Chem 265: 15275–15279PubMedGoogle Scholar
  18. Blake MJ, Nowak TS, Holbrook NJ (1990b): In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress. Mol Brain Res 8: 89–92PubMedGoogle Scholar
  19. Blake MJ, Udelsman R, Feulner GJ, Norton DD, Holbrook NJ (1991): Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response. Proc Natl Acad Sci USA 88:9873–9877PubMedGoogle Scholar
  20. Bonner JJ, Ballou C, Fackenthal DL (1994): Interactions between DNA-bound trimers of the yeast heat shock factor. Mol Cell Biol 14: 501–508PubMedGoogle Scholar
  21. Capdevila MD, Garcia-Bellido A (1974): Development and genetic analysis of bithorax phenocopies in Drosophila. Nature 250: 500–502Google Scholar
  22. Chen Y, Barlev NA, Westergaard O, Jakobsen BK (1993): Identification of the C-terminal activator domain in yeast heat shock factor: independent control of transient and sustained transcriptional activity. EMBO J 12: 5007–5018PubMedGoogle Scholar
  23. Choi HS, Lin Z, Li B, Liu A-C (1990): Age-dependent decrease in the heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts. J Biol Chem 265: 18005–18011PubMedGoogle Scholar
  24. Clos J, Rabindran S, Wisniewski J, Wu C (1993): Induction temperature of human heat shock factor is reprogrammed in a Drosophila cell environment. Nature 364: 252–255PubMedGoogle Scholar
  25. Clos J, Westwood JT, Becker PB, Wilson S, Lambert K, Wu C (1990): Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation. Cell 63: 1085–1097PubMedGoogle Scholar
  26. Corces V, Holmgren R, Freund R, Morimoto R, Meselson M (1980): Four heat shock proteins of Drosophila melanogaster coded within a 12-kilobase region in chromosome subdivision 67B. Proc Natl Acad Sci USA 77: 5390–5393PubMedGoogle Scholar
  27. Corces V, Pellicer A, Axel R, Meselson M (1981): Integration, transcription, and control of a Drosophila heat shock gene in mouse cells. Proc Natl Acad Sci USA 78: 7038–7042PubMedGoogle Scholar
  28. Cotto J (1994): personal communicationGoogle Scholar
  29. Craig EA (1993): Chaperones: Helpers along the pathway to protein folding. Science 260: 1902–1903PubMedGoogle Scholar
  30. Craig EA, Gambill BD, Nelson RJ (1993): Heat shock proteins: molecular chaperones of protein biogenesis. Microbiol Rev 57: 402–414PubMedGoogle Scholar
  31. Craig EA, McCarthy BJ, Wadsworth S (1979): Sequence organization of two recombinant plasmids containing genes for the major heat shock induced protein in Drosophila melanogaster. Cell 16: 575–583PubMedGoogle Scholar
  32. Currie RW, White FP (1993): Heat shock and limitation of tissue necrosis during occlusion/reperfusion in rabbit hearts. Circulation 87: 963–971PubMedGoogle Scholar
  33. DiDomenico BJ, Bugaisky GE, Lindquist S (1982): The Heat Shock Response is Regulated at both the Transcriptional and Posttranscriptional Levels. Cell 31: 593–603PubMedGoogle Scholar
  34. Dorner AJ, Wasley LC, Kaufman RJ (1992): Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells. EMBO J 11: 1563–1571PubMedGoogle Scholar
  35. Ferris DK, Harel-Bellan A, Morimoto RI, Welch WJ, Farrar WL (1988):Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proc Natl Acad Sci USA 85: 3850–3854PubMedGoogle Scholar
  36. Gallo GJ, Schuetz TJ, Kingston RE (1991): Regulation of heat shock factor in Schizosaccharomyces pombe more closely resembles regulation in mammals than in Saccharomyces cerevisiae. Mol Cell Biol 11: 281–288PubMedGoogle Scholar
  37. Georgopoulos C, Welch WJ (1993): Role of major heat shock proteins as molecular chaperones. Ann Rev Cell Biol 9: 601–635PubMedGoogle Scholar
  38. Gething M-J, Sambrook J (1992): Protein folding in the cell. Nature 355: 33–45PubMedGoogle Scholar
  39. Goff SA, Goldberg AL (1985): Production of abnormal proteins in E. coli stimulates transcription of Ion and other heat shock genes. Cell 41: 587–595PubMedGoogle Scholar
  40. Goldschmidt R (1935): Gen und Ausseneigenschaft. 1. (Untersuchung an Drosophila). Z Indukt Abstammungs Vererbungst 69: 38–131Google Scholar
  41. Greene JM, Kingston RE (1990): TATA-dependent and TATA-independent function of the basal and heat shock elements of a human hsp70 promoter. Mol Cell Biol 10(4): 1319–1328PubMedGoogle Scholar
  42. Greene JM, Larin Z, Taylor IC, Prentice H, Gwinn KA, Kingston RE (1987): Multiple basal elements of a human hsp70 promoter function differently in human and rodent cell lines. Mol Cell Biol 7(10): 3646–3655PubMedGoogle Scholar
  43. Hard FU, Martin J, Neupert W (1992): Protein folding in the cell: the role of molecular chaperones Hsp70 and Hsp60. Annu Rev Biophys Biomol Struct 21: 292–322Google Scholar
  44. Hendrick JP, Hartl F-U (1993): Molecular chaperone functions of heat-shock proteins. Annu Rev Biochem 62: 349–384PubMedGoogle Scholar
  45. Heydari AR, Wu B, Takahashi R, Strong R, Richardson A (1993): Expression of heat shock protein 70 is altered by age and diet at the level of transcription. Mol Cell Biol 13: 2909–2918PubMedGoogle Scholar
  46. Hightower LE (1991): Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 66: 191–197PubMedGoogle Scholar
  47. Holbrook NJ, Carlson SG, Choi AMK, Fargnoli J (1992): Induction of HSP70 gene expression by the antiproliferative prostaglandin PGA2: a growth-dependent response mediated by activation of heat shock transcription factor. Mol Cell Biol 12: 1528–1534PubMedGoogle Scholar
  48. Holbrook NJ, Udelsman R (1994): Heat shock protein gene expression in response to physiologic stress and aging. In: The Biology of Heat Shock Proteins and Molecular Chaperones. Morimoto RI, Tissieres A, Georgopoulos C, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press (in press)Google Scholar
  49. Holmgren R, Corces V, Morimoto R, Blackman R, Meselson M (1981): Sequence homologies in the 5’ regions of four Drosophila heat-shock genes. Proc Natl Acad Sci USA 3775–3778Google Scholar
  50. Holmgren R, Livak K, Morimoto R, Freund R, Meselson M (1979): Studies of cloned sequences from four Drosophila heat shock loci. Cell 18: 1359–1370PubMedGoogle Scholar
  51. Hosokawa N, Hirayoshi K, Kudo H, Takechi H, Aoike A, Kawai K, Nagata K (1992): Inhibition of activation of heat shock factor in vivo and in vitro by flavanoids. Mol Cell Biol 12: 3490–3498PubMedGoogle Scholar
  52. Hunt C, Morimoto RI (1985): Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proc Natl Acad Sci USA 82: 6455–6459PubMedGoogle Scholar
  53. Jakobsen BK, Pelham HR (1988): Constitutive binding of yeast heat shock factor to DNA in vivo. Mol Cell Biol 8: 5040–5042PubMedGoogle Scholar
  54. Jakobsen BK, Pelham HRB (1991): A conserved heptapeptide restrains the activity of the yeast heat shock transcription factor. EMBO J 10: 369–375PubMedGoogle Scholar
  55. Jurivich D, Sistonen L, Sarge KD, Morimoto RI (1994): Arachidonate is a potent modulator of human heat shock gene transcription. Proc Natl Acad Sci USA 91: 2280–2284PubMedGoogle Scholar
  56. Jurivich DA, Sistonen, L, Kroes, RA, Morimoto RI (1992): Effect of sodium salicylate on the human heat shock response. Science 255: 1243–1245PubMedGoogle Scholar
  57. Kingston RET, Schuetz TJ, Larin Z (1987): Heat-inducible human factor that binds to a human hsp70 promoter. Mol Cell Biol 7: 1530–1534PubMedGoogle Scholar
  58. Kline M (1994): unpublished observationGoogle Scholar
  59. Kohno K, Normington K, Sambrook J, Gething MJ, Mori K (1993): The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol Cell Biol 13: 877–890PubMedGoogle Scholar
  60. Kroeger P (1994): unpublished observationGoogle Scholar
  61. Kroeger P, Morimoto R (1994): Selection of new HSF1 and HSF2 DNA binding sites reveals differences in trimer cooperativity. Mol. Cell Biol: in pressGoogle Scholar
  62. Kroeger PE, Sarge KD, Morimoto RI (1993): Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element. Mol Cell Biol 13: 3370–3383PubMedGoogle Scholar
  63. Landry J, Chretien P, Lambert H, Hickey E, Weber A (1989): Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. J Cell Biol 109: 7–15PubMedGoogle Scholar
  64. Larson JS, Schuetz TJ, Kingston RE (1988): Activation in vitro of sequence-specific DNA binding by a human regulatory factor. Nature 335: 372–375PubMedGoogle Scholar
  65. Lavoie JN, Gingras-Breton, G, Tanguay RM, Landry J (1993): Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock.J Biol Chem 268: 3420–3429PubMedGoogle Scholar
  66. Lee H, Kraus KW, Wolfner MF, Lis JT (1992): DNA sequence requirements for generating paused polymerase at the start of hsp70. Genes Dev 6: 284–295PubMedGoogle Scholar
  67. Li GC, Li LG, Liu RY, Rehman M, Lee WM (1992): Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain. Proc Natl Acad Sci USA 89: 2036–2040PubMedGoogle Scholar
  68. Li GC, Werb Z (1982): Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese fibroblast. Proc Natl Acad Sci USA 79: 3218–3222PubMedGoogle Scholar
  69. Li WW, Sistonen L, Morimoto RI, Lee AS (1994): Stress induction of mammalian GRP78/Bip protein gene: in vivo genomic footprinting and the identification of p70CORE from human nuclear extract as a DNA binding component to the stress regulatory element. Mol Cell Biol: in pressGoogle Scholar
  70. Lindquist S (1980): Translational efficiency of heat induced messages in Drosophila melanogaster cells.J Mol Biol 137: 151–158PubMedGoogle Scholar
  71. Lindquist S (1986): The Heat-Shock response. Ann Rev Biochem 55: 1151–1191PubMedGoogle Scholar
  72. Lindquist S, Craig EA (1988): The heat shock proteins. Annu Rev Genet 22: 631–677PubMedGoogle Scholar
  73. Lindquist-Mckenzie SL, Meselson M (1977): Translation in vitro of Drosophila heat shock messages. J Mol Biol 117: 279–283Google Scholar
  74. Lindquist-Mckenzie SL, Henikoff S, Meselon M (1975): Localization of RNA from heat-induced polysomes at puff sites in Drosophila melanogaster. Proc Natl Acad Sci USA 72: 1117–1121Google Scholar
  75. Lis J, Wu C (1993): Protein traffic on the heat shock promoter: parking, stalling, and trucking along. Cell 14: 1–4Google Scholar
  76. Liu AY, Lin Z, Choi HS, Sorhage F, Li B (1989): Attenuated induction of heat shock gene expression in aging diploid fibroblasts. J Biol Chem 264: 12037–12045PubMedGoogle Scholar
  77. Liu Y, Kato H, Nakata N, Kogure K (1992): Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia. Brain Res 586: 121–124PubMedGoogle Scholar
  78. Livak KJ, Freund R, Schwebe M, Wensink PC, Meselson M (1978): Sequence organization and transcription at two heat shock loci in Drosophila. Proc Natl Acad Sci USA 75: 5613–5617PubMedGoogle Scholar
  79. Lowe DG, Fulford WD, Moran LA (1983): Mouse and Drosophila genes encoding the major heat shock protein (Hsp70) are highly conserved. Mol Cell Biol 3: 1540–1543PubMedGoogle Scholar
  80. Lu Q, Wallrath LL, Granok H, Elgin S C (1993): (CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene. Mole Cell Biol 13: 2802–2814Google Scholar
  81. Lum LSY, Sultzman LA, Kaufman RJ, Linzer DIH, Wu B (1990): A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. Mol Cell Biol 10: 6709–6717PubMedGoogle Scholar
  82. Marber MS, Latchman DS, Walker JM, Yellon DM (1993): Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88: 1264–1272PubMedGoogle Scholar
  83. Mathur S, Sistonen L, Brown IB, Murphy SP, Sarge KD, Morimoto RI (1994): Deficient induction of human HSP70 gene transcription in Y79 retinoblastoma cells despite activation of HSF1. Proc Natl Acad Sci USA: in pressGoogle Scholar
  84. Milarski KL, Morimoto RI (1986): Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci USA 83: 9517–9521PubMedGoogle Scholar
  85. Mirault M-E, Southgate R, Delwart E (1982): Regulation of heat shock genes: a DNA sequence upstream of Drosophila hsp70 genes is essential for their induction in monkey cells. EMBO J 1: 1279–1285PubMedGoogle Scholar
  86. Moran L, Mirault ME, Tissieres A, Lis J, Schedl P, Artranis-Tsakonas S, Gehring WJ (1979): Physical map of two Drosophila melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Cell 17: 1–8PubMedGoogle Scholar
  87. Morgan WD (1989): Transcription factor Sp1 binds to and activates a human HSP70 gene promoter. Mol Cell Biol 9: 4099–4104PubMedGoogle Scholar
  88. Morgan WD, Williams GT, Morimoto RI, Greene J, Kingston RE, Tjian R (1987): Two transcriptional activators, CCAAT-box binding transcription factor and heat shock transcription factor, interact with a human HSP70 gene promoter. Mol Cell Biol 7: 1129–1138PubMedGoogle Scholar
  89. Mori K, Sant A, Kohno K, Normington K, Gething MJ, Sambrook JF (1992): A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins. EMBO J 11: 2583–2593PubMedGoogle Scholar
  90. Morimoto RI (1991): Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation. Cancer Cells 3: 297–301Google Scholar
  91. Morimoto RI (1993): Chaperoning the nascent polypeptide chain. Curr Biol 3: 101–102Google Scholar
  92. Morimoto RI, Milarski KL (1990): Expression and function of vertebrate hsp70 genes. In: Stress Proteins in Biology and Medicine. Morimoto RI, Tissieres A, Georgopoulos C, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory PressGoogle Scholar
  93. Morimoto RI, Abravaya K, Mosser D, Williams GT (1990): Transcriptional regulation of the human HSP70 gene: cis-acting elements and transacting factors involved in basal, adenovirus Ela, and stress-induced expression. In: Stress Proteins. Schlesinger M, Santoro MG, Garaci E, eds. Berlin: Springer-VerlagGoogle Scholar
  94. Morimoto RI, Hunt C, Huang S-Y, Berg KL, Banerji SS (1986): Organization, nucleotide sequence, and transcription of the chicken HSP70 gene. J Biol Chem 261: 12692–12699PubMedGoogle Scholar
  95. Morimoto RI, Jurivich DA, Kroeger PE, Mathur SK, Murphy SP, Nakai A, Sarge K, Abravaya K, Sistonen L (1994): The regulation of heat shock gene expression by a family of heat shock factors. In: The Biology of Heat Shock Proteins and Molecular Chaperones. Morimoto AI, Tissieres A, Georgopoulos C, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory PressGoogle Scholar
  96. Mosser DD, Duchaine J, Massie B (1993): The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70. Mol Cell Biol 13: 5427–5438PubMedGoogle Scholar
  97. Mosser DD, Kotzbauer PT, Sarge KD, Morimoto RI (1990): In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proc Natl Acad Sci USA 87: 3748–3752PubMedGoogle Scholar
  98. Mosser DD, Theodorakis NG, Morimoto RI (1988): Coordinate changes in heat shock element-binding activity and hsp70 gene transcription rates in human cells. Mol Cell Biol 8: 4736–4744PubMedGoogle Scholar
  99. Murphy S, Phillips B (1994): unpublished observationGoogle Scholar
  100. Nakai A, Morimoto RI (1993): Characterization of a novel chicken heat shock transcription factor, HSF3, suggests a new regulatory pathway. Mol Cell Biol 13: 1983–1997PubMedGoogle Scholar
  101. Nakai A, Nagata K, Morimoto R (1994): unpublished observationGoogle Scholar
  102. Nelson RJ, Ziegelhoffer T, Nicolet C, Werner-Washburne M, Craig EA (1992): The translation machinery and seventy kilodalton heat shock protein cooperate in protein synthesis. Cell 71: 97–105PubMedGoogle Scholar
  103. Nieto-Sotelo J, Wiederrecht G, Okuda A, Parker CS (1990): The yeast heat shock transcription factor contains a transcriptional activation domain whose activity is repressed under nonshock conditions. Cell 62: 807–817PubMedGoogle Scholar
  104. Nowak TS, Abe H (1994): The postischemic stress response in brain. In: The Biology of Heat Shock Proteins and Molecular Chaperones. Morimoto RI, Tissieres A, Georgopoulos C, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press (in press)Google Scholar
  105. Parsell DA, Taulien J, Lindquist S (1993): The role of heat-shock proteins in thermotolerance. Philoa Trans R Soc Lond Biol 339: 279–285Google Scholar
  106. Pederson DS, Fidrych T (1994): Heat shock factor can activate transcription while bound to nucleosomal DNA in Saccharomyces cerevisiae. Mol Cell Biol 14: 189–199Google Scholar
  107. Pelham HRB (1982): A regulatory upstream promoter element in the Drosophila hsp 70 heat-shock gene. Cell 30: 517–528PubMedGoogle Scholar
  108. Pelham HRB, Bienz M (1982): A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene. EMBO J 1: 1473–1477PubMedGoogle Scholar
  109. Perisic O, Xiao H, Lis JT (1989): Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit. Cell 59: 797–806PubMedGoogle Scholar
  110. Peteranderl R, Nelson HCM (1992): Trimerization of the heat shock transcription factor by a triple-stranded α-helical coiled-coil. Biochemistry 31: 12272–12276PubMedGoogle Scholar
  111. Phillips B, Morimoto RI (1991): Transcriptional regulation of human hsp70 genes: relationship between cell growth, differentiation, virus infection, and the stress response. In: Heat Shock and Development. Hightower LE, Nover L, eds. Heidelberg: Springer Verlag PressGoogle Scholar
  112. Pleet H, Graham J, Smith JM, Smith DW (1981): Central nervous system and facial defects associated with maternal hyperthermia at four to 14 weeks gestation. Pediatrics 67: 785–789PubMedGoogle Scholar
  113. Pollack R, Treisman R (1990): A sensitive method for the determination of protein-DNA binding specificities. Nuc Acids Res 18: 6197–6204Google Scholar
  114. Pulsinelli, WA, Brierley JB, Plum F (1982): Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491–498PubMedGoogle Scholar
  115. Rabindran SK, Giorgi G, Clos J, Wu C (1991): Molecular cloning and expression of a human heat shock factor, HSF1. Proc Natl Acad Sci USA 88: 6906–6910PubMedGoogle Scholar
  116. Rabindran SK, Haroun RI, Clos J, Wisniewski J, Wu C (1993): Regulation of heat shock factor trimer formation: role of a conserved leucine zipper. Science 259: 230–234PubMedGoogle Scholar
  117. Ritossa FM (1962): A new puffing pattern induced by a temperature shock and DNP in Drosophila. Experientia 18: 571–573Google Scholar
  118. Rothman JE (1989): Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells. Cell 59: 591–601PubMedGoogle Scholar
  119. Rougive AE, Lis JT (1988): The RNA polymerase II molecule at the 5’ end of the uninduced hsp70 gene in D. melanogaster is transcriptionally engaged. Cell 54: 795–804Google Scholar
  120. Rougive AE, Lis JT (1990): Postinitiation transcriptional control in Drosophila melanogaster. Mol Cell Biol 10: 6041–6045Google Scholar
  121. Sarge KD, Murphy SP, Morimoto RI (1993): Activation of heat shock gene transcription by HSF1 involves oligomerization, acquisition of DNA binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol 13: 1392–1407PubMedGoogle Scholar
  122. Sarge KD, Park-Sarge OY, Kirby D, Mayo K, Morimoto RI (1994): Regulated expression of heat shock factor 2 in mouse testis: potential role as a regulator of HSP gene expression during spermatogenesis. Biol Reprod: 50: 1334–1343PubMedGoogle Scholar
  123. Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI (1991): Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes & Dev 5: 1902–1911Google Scholar
  124. Scharf K-D, Rose S, Zott W, Schoff F, Nover L (1990): Three tomato genes code for heat stress transcription factors with a remarkable degree of homology to the DNA-binding domain of the yeast HSF. EMBO J 9: 4495–501PubMedGoogle Scholar
  125. Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (1991): Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc Natl Acad Sci USA 88: 6910–6915Google Scholar
  126. Silar P, Butle G, Thiele DJ (1991): Heat shock transcription factor activates transcription of the yeast metallothionein gene. Mol Cell Biol 11: 1232–1238PubMedGoogle Scholar
  127. Sistonen L, Sarge KD, Morimoto R (1994): Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Mol Cell Biol 14: 2087–2099PubMedGoogle Scholar
  128. Sistonen L, Sarge KD, Phillips B, Abravaya K, Morimoto R (1992): Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Moll Cell Biol 12(9): 4104–4111Google Scholar
  129. Skroch P, Buchman C, Karin M (1993): Regulation of human and yeast metallothionein gene transcription by heavy metal ions. Prog Clin Biol Res 380: 113–128PubMedGoogle Scholar
  130. Sorger PK (1990): Yeast heat shock factor contains separable transient and sustained response transcriptional activators. Cell 62: 793–805PubMedGoogle Scholar
  131. Sorger PK, Nelson HCM (1989): Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell 59: 807–813PubMedGoogle Scholar
  132. Sorger PK, Pelham HRB (1988): Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 54: 855–864PubMedGoogle Scholar
  133. Sorger PK, Lewis MJ, Pelham HRB (1987): Heat shock factor is regulated differently in yeast and HeLa cells. Nature 329: 81–84PubMedGoogle Scholar
  134. Spradling A, Pardue ML, Penman S (1977): Messenger RNA in heat-shocked Drosophila cells.J Mol Biol 109: 559–587PubMedGoogle Scholar
  135. Spradling A, Penman S, Pardue ML (1975): Analysis of Drosophila mRNA by in situ hybridization: Sequences transcribed in normal and heat shock cultured cells. Cell 4: 395–404PubMedGoogle Scholar
  136. Storti RV, Scott MP, Rich A, Pardue ML (1980): Translational control of protein synthesis in response to heat shock in D. melanogaster cells. Cell 22: 825–834PubMedGoogle Scholar
  137. Taylor ICA, Workman JL, Schuetz TJ, Kingston RE (1991): Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains. Genes & Dev 5: 1285–1298Google Scholar
  138. Theodorakis NG, Zand DJ, Kotzbauer PT, Williams GT, Morimoto RI (1989): Hemin-induced transcriptional activation of the hsp70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response. Mol Cell Biol 9: 3166–3173PubMedGoogle Scholar
  139. Tissieres A, Mitchell KH, Tracy VM (1974): Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs. J Mol Biol 84: 389–398PubMedGoogle Scholar
  140. Treuter E, Nover L, Ohme K, Scharf KD (1993): Promoter specificity and deletion analysis of three tomato heat stress transcription factors. Mol Gen Genet 240: 113–125PubMedGoogle Scholar
  141. Tsukiyama T, Becker P, Wu C (1994): ATP-dependent nucleosome disruption at a heat-shock promoter mediated by the binding of GAGA transcription factor. Nature 367: 525–532PubMedGoogle Scholar
  142. Udelsman R, Blake MJ, Stagg CA, Li D, Putney DJ, Holbrook NJ (1993): Vascular heat shock protein expression in response to stress. J Clin Invest 91: 465–473PubMedGoogle Scholar
  143. Voellmy R, Ahmed A, Schiller P, Bromley P, Rungger D (1985): Isolation and functional analysis of a human 70,000 dalton heat shock protein gene segment. Proc Natl Acad Sci USA 82: 4949–4953PubMedGoogle Scholar
  144. Voellmy R, Goldschmidt-Clermont, Southgate R, Tissieres A, Levis R, Coehring W (1981): A DNA segment isolated from chromosomal site 67B in Drosophila melanogaster contains four closely linked heat shock genes. Cell 23: 261–270PubMedGoogle Scholar
  145. Vogel JP, Misra M, Rose MD (1990): Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast. J Cell Biol 110: 1885–1895PubMedGoogle Scholar
  146. Watowich SS, Morimoto RI, Lamb RA (1991): Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene.J Virol 65: 3590–3597PubMedGoogle Scholar
  147. Webster WS, Gerrain MA, Edwards MJ (1985): The introduction of microthalmia, encephalocele, and other heat defects following hyperthermia during the gastrulation process in the rat. Teratology 31: 73–82PubMedGoogle Scholar
  148. Welch WJ, Feramisco JR (1984): Nuclear and nucleolar localization of the 72,000 dalton heat shock protein in heat-shocked cells.J Biol Chem 259: 4501–4513PubMedGoogle Scholar
  149. Westwood JT, Clos J, Wu C (1991): Stress-induced oligomerization and chromosomal relocalization of heat-shock factor. Nature 353: 822–827PubMedGoogle Scholar
  150. Westwood JT, Wu C (1993): Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition. Mol Cell Biol 13: 3481–3486PubMedGoogle Scholar
  151. Wiederrecht G, Seto D, Parker CS (1988): Isolation of the gene encoding the S. cerevisiae heat shock transcription factor. Cell 54: 841–853PubMedGoogle Scholar
  152. Williams GT, McClanahan TK, Morimoto RI (1989): Ela transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Mol Cell Biol 9: 2574–2587PubMedGoogle Scholar
  153. Williams GT, Morimoto RI (1990): Maximal stress-induced transcription from the human hsp70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Mol Cell Biol 10: 3125–3136PubMedGoogle Scholar
  154. Williams RS, Benjamin IJ (1993): Human HSP70 protects murine cells from injury during metabolic stress. J Clin Invest 92: 503–508PubMedGoogle Scholar
  155. Wooden SK, Li LJ, Navarro D, Qadri I, Pereira L, Lee AS (1991): Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I. Mol Cell Biol 11: 5612–5623PubMedGoogle Scholar
  156. Wu B, Hunt C, Morimoto RI (1985): Structure and expression of the human gene encoding major heat shock protein HSP70. Mol Cell Biol 5: 330–341PubMedGoogle Scholar
  157. Wu B, Hurst H, Jones N, Morimoto RI (1986a): The Ela 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene. Mol Cell Biol 6: 2994–2999PubMedGoogle Scholar
  158. Wu BJ, Kingston RE, Morimoto RI (1986b): Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci USA 83: 929–633Google Scholar
  159. Wu C (1980): The 5’ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature 286: 854–860PubMedGoogle Scholar
  160. Wu C (1984): Two protein-binding sites in chromatin implicated in the activation of heat-shock genes. Nature 309: 229–234PubMedGoogle Scholar
  161. Wu C, Wilson S, Walker B, David I, Paisley T, Zimarino V, Ueda H (1987): Purification and properties of Drosophila heat shock activator protein. Science 238: 1247–1253PubMedGoogle Scholar
  162. Xiao H, Lis JT (1988): Germline transformation used to define key features of the heat shock response element. Science 239: 1139–1142PubMedGoogle Scholar
  163. Xiao H, Perisic O, Lis JT (1991): Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit. Cell 64: 585–593PubMedGoogle Scholar
  164. Zhong T, Arndt K (1993): The yeast SIS1 protein, a DnaJ homolog, is required for the initiation of translation. Cell 73: 1175–1186PubMedGoogle Scholar
  165. Zimarino V, Wu C (1987): Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis. Nature 327: 727–730PubMedGoogle Scholar

Copyright information

© Birkhäuser Boston 1995

Authors and Affiliations

  • Paul E. Kroeger
  • Richard I. Morimoto

There are no affiliations available

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