Direct Signal Transduction by Tyrosine Phosphorylation of Transcription Factors with SH2 Domains

  • Xin-Yuan Fu
Part of the Progress in Gene Expression book series (PRGE)


A living cell is constantly receiving and responding to a variety of extracellular signals. Many of these signals are polypeptides such as hormones, growth factors, cytokines, neural transmitters, antigens and cell matrix proteins. The state of cell metabolism, proliferation, differentiation, and other phenotypes are controlled by these polypeptide ligands. The signal transduction of these polypeptide ligands depends on their specific cell surface receptors. A ligand exerts its action by binding to its receptor on the cell surface and then initiating a chain of reactions within the cell through the intracellular domain of the receptor, which often contains or associates with certain enzymatic activities.


Tyrosine Phosphorylation Mutant Cell Line Direct Effector Model Polypeptide Ligand Heptad Leucine Repeat 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Birkhäuser Boston 1995

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  • Xin-Yuan Fu

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