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Building Protein Folds Using Distance Geometry: Towards a General Modeling and Prediction Method

  • William R. Taylor
  • András Aszódi

Abstract

A known protein structure can be modified and manipulated to produce a model for another protein with which it shares some sequence similarity. Typical changes involve the substitution and reorientation of side chains and the remodeling of the main chain to accommodate possible insertions and deletions of sequences. Where the two sequences are clearly related (say, more than 50%), such changes are relatively minor and a model can easily be constructed automatically.

Keywords

Secondary Structure Distance Matrix Hydrophobic Residue Globular Protein Distance Constraint 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Boston 1994

Authors and Affiliations

  • William R. Taylor
  • András Aszódi

There are no affiliations available

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