In Search of Protein Folds
The protein folding problem is exciting as well as frustrating. A large body of knowledge on protein folds has accumulated over past decades, but it is still impossible to calculate native structures from amino acid sequences. Our duty is to present the reasoning behind an approach that attempts to derive an energy model of protein solvent systems from the information contained in experimentally determined protein structures. The result of this approach is called knowledge-based mean field. The goal is to employ this model in the search for the native fold of amino acid sequences of unknown structure. We present an overview of the principles involved in this approach, assess the current state of the art, and present several applications in protein structure theory.
KeywordsForce Field Fold Recognition Constant Domain Swissprot Database Native Fold
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