GABAB Receptors on Inhibitory Neurons in the Hippocampus

  • Nevin A. Lambert
  • Neil L. Harrison


Approximately 11% of the neurons in the hippocampal formation contain the inhibitory neurotransmitter 7-aminobutyric acid (GABA; Woodson et al., 1989). There are several morphologically and functionally distinct subpopulations of GABA-containing neurons in the hippocampus (Ramón y Cajal, 1911; Lorente de No, 1934; Amarai, 1978; Lacaille et al., 1989). However, most of these neurons share common features that distinguish them from pyramidal and granule cells, the principal neurons in the hippocampus. Their cell bodies are not restricted to discrete layers, and their dendrites lack spines. The axons of most GABA-containing neurons ramify locally and do not project outside of the hippocampus. For this reason, these neurons are also called local circuit neurons, or interneurons (Lacaille et al., 1989). Intracellular recordings from interneurons in hippocampal slices have shown that many generate nonaccommodating trains of brief action potentials (Schwartzkroin and Mathers, 1978).


Hippocampal Slice Inhibitory Neuron Gaba Release Inhibitory Synaptic Transmission Inhibitory Terminal 
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© Birkhäuser Boston 1993

Authors and Affiliations

  • Nevin A. Lambert
  • Neil L. Harrison

There are no affiliations available

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