Glutamate Autoreceptors in Mammalian Brain

  • David M. Lovinger
  • Nevin A. Lambert


Neurotransmitter receptors that reside on presynaptic terminals which release the receptor-activating transmitter are known as autoreceptors (see Bartfai et al., 1988, for review). Activation of an autoreceptor by a particular neurotransmitter is presumed to regulate secretion of that same transmitter. Autoreceptors for a number of transmitters have now been identified. Most notable among these are the α1 adrenoreceptor in the peripheral nervous system (Alberts et al., 1981), the dopamine receptors present on neurons in substantia nigra (Carlsson, 1975), and the GABAB receptors present on GABAergic neurons (see Chapter 9; Baumann et al., 1990). In most cases autoreceptors belong to the class of receptors linked to guanosine triphosphate (GTP)-binding proteins (G proteins). Their mechanisms of action are thought to involve decreases in presynaptic terminal excitability via activation of K+ conductances, decreases in calcium influx into presynaptic terminals via inhibition of voltage-gated calcium channel function, or direct actions on transmitter-containing vesicles.


Glutamate Receptor Metabotropic Glutamate Receptor Metabotropic Receptor Synaptic Depression Excitatory Synaptic Transmission 
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© Birkhäuser Boston 1993

Authors and Affiliations

  • David M. Lovinger
  • Nevin A. Lambert

There are no affiliations available

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