Presynaptic and Postsynaptic Actions of Somatostatin in Area CA1 and the Dentate Gyrus of Rat and Rabbit Hippocampal Slices

  • Helen E. Scharfman


Specific peptides that may be neurotransmitters or neuromodulators are found in a variety of neurons in the central nervous system. Often these “neuropeptides” are packaged in combination with classical neurotransmitters (Hökfelt et al., 1986; Iversen and Goodman, 1986; Kupfermann, 1991). A great deal of information concerning the colocalization of neuropeptides and classical neurotransmitters has resulted from immunocytochemical studies. However, the exact physiological function of many neuropeptides has been elusive. Even in cases where physiologists have determined the effects of exogenous application of peptides on discrete brain areas, how the neuropeptides function in situ is not necessarily clear. Moreover, it is often unclear if a neuropeptide acts in concert with the classical neurotransmitter packaged in the same cell, whether the neuropeptide acts independently from the classical neurotransmitter, or whether the neuropeptide acts in both ways under different circumstances.


Dentate Gyrus Pyramidal Cell Stratum Radiatum Synaptic Potential Postsynaptic Action 
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© Birkhäuser Boston 1993

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  • Helen E. Scharfman

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