Abstract
Two purposes guided the writing of this introductory chapter. My first objective was to provide a concise history and background to the topic covered in this book. In doing so, I have drawn from specific examples of presynaptic inhibition that are not addressed in later chapters. This is an attempt to bind together work performed on a variety of preparations to provide an expanded view of our understanding of the mechanisms of presynaptic inhibition and how this understanding was obtained. It is anticipated that a discussion of these issues will expose important links between mechanisms of presynaptic inhibition in different preparations. A more thorough historical background can be obtained from Eccles (1964) and Nicoli and Alger (1979). My second objective was to present areas of research that I believe will be important in the near future or that perhaps deserve more attention than they have received.
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References
Anwyl R (1991): Modulation of vertebrate neuronal calcium channels by transmitters. Brain Res Rev 16:265–281
Barron DH, Matthews BHC (1938): The interpretation of potential changes in the spinal cord. J Physiol (Lond) 92:276–321
Baskys A, Malenka RC (1991): Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus. J Physiol (Lond) 444:687–701
Baxter DA, Bittner GD (1991): Synaptic plasticity at crayfish neuromuscular junctions: presynaptic inhibition. Synapse 7:244–251
Bean BP (1989): Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340:153–156
Bowery N (1989): GABAB receptors and their significance in mammalian pharmacology. Trends Pharm Sci 10:401–407
Brock LG, Coombs JS, Eccles JC (1952): The recording of potentials from motoneurones with an intracellular electrode. J Physiol (Lond) 117:431–460
Brown AM, Birnbaumer L (1990): Ionic channels and their regulation by G protein subunits. Annu Rev Physiol 52:197–213
Byrne JH (1980): Identification of neurons contributing to presynaptic inhibition in Aplysia californica. Brain Res 199:235–239
Charlton MP, Smith SJ, Zucker RS (1982): Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse. J Physiol (Lond) 323:173–193
Clements JD, Forsythe ID, Redman SJ (1987): Presynaptic inhibition of synaptic potentials evoked in cat spinal motoneurones by impulses in single group la axons. J Physiol (Lond) 383:153–169
Cooper S, Creed RS (1927): More reflex effects of active muscular contraction. J Physiol (Lond) 64:199–214
Dale N, Kandel ER (1990): Facilitatory and inhibitory transmitters modulate spontaneous transmitter release at cultured Aplysia sensorimotor synapses. J Physiol (Lond) 421:203–222
De Camilli P, Jahn R (1990): Pathways to regulated exocytosis in neurons. Annu Rev Physiol 52:625–645
Delaney KR, Tank DW, Zucker RS (1991): Presynaptic calcium and serotonin-mediated enhancement of transmitter release at crayfish neuromuscular junction. J Neurosci 11:2631–2643
Dudel J, Kuffler SW (1961): Presynaptic inhibition at the crayfish neuromuscular junction. J Physiol (Lond) 155:543–562
Dunlap K, Fischbach GD (1978): Neurotransmitters decrease the calcium component of sensory neurone action potentials. Nature 276:837–839
Eccles JC (1961): The nature of central inhibition. Proc Roy Soc B 153:445–476
Eccles JC (1964): The Physiology of Synapses. New York: Springer-Verlag, Inc.
Eccles JC, Kostyuk PG, Schmidt RF (1962): Central pathways responsible for depolarization of primary afferent fibres. J Physiol (Lond) 161:237–257
Eccles JC, Schmidt R, Willis WD (1963): Pharmacological studies on presynaptic inhibition. J Physiol (Lond) 168:500–530
Elmslie KS, Zhou W, Jone SW (1990): LHRH and GTP-gamma-S modify calcium current activation in bullfrog sympathetic neurons. Neuron 5:75–80
Forscher P, Oxford GS (1985): Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons. J Gen Physiol 85:743–763
Fox S, Krnjevic K, Morris ME, Puil E, Wierman R (1978): Action of baclofen on mammalian synaptic transmission. Neuroscience 3:495–515
Frank K (1959): Basic mechanisms of synaptic transmission in the central nervous system. IRE Trans Med Electron ME-6:85–88
Frank K, Fuortes MGF (1957): Presynaptic and postsynaptic inhibition of monosynaptic reflexes. Fed Proc 16:39–40
Gage PW (1992): Activation and modulation of neuronal K+ channels by GABA. Trends in Neurosci 15:46–51
Gasser HS, Graham HT (1933): Potentials produced in the spinal cord by stimulation of dorsal roots. Am J Physiol 103:303–320
Gerber U, Greene RW, Haas HL, Stevens DR (1989): Characterization of inhibition mediated by adenosine in the hippocampus of the rat in vitro. J Physiol (Lond) 417:567–578
Gingrich KJ, Baxter DA, Byrne JH (1988): Mathematical model of cellular mechanisms contributing to presynaptic facilitation. Brain Res Bull 21:513–520
Grassi F, Lux HD (1989): Voltage-dependent GABA-induced modulation of calcium currents in sensory neurons. Neurosci Lett 105:113–119
Hill DR, Bowery NG (1981): 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290:149–152
Hughes J, Gasser HS (1934a): Some properties of the cord potentials evoked by a single afferent volley. Am J Physiol 108:295–306
Hughes J, Gasser HS (1934b): The response of the spinal cord to two afferent volleys. Am J Physiol 108:301–321
Kalman D, O’Lague PH, Erxleben C, Armstrong DL (1988): Calcium-dependent inactivation of the dihydropyridine-sensitive calcium channels in GH3 cells. J Gen Physiol 92:531–548
Kalsner S, Westfall TC (1990): Presynaptic receptors and the question of autoregulation of neurotransmitter release. Ann NY Acad Sci 604
Kasai H, Aosaki T (1989): Modulation of Ca-channel current by an adenosine analog mediated by a GTP-binding protein in chick sensory neurons. Pflugers Arch 414:145–149
Kramer RH, Kaczmarek LK, Levitan ES (1991): Neuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium. Neuron 6:557–563
Kretz R, Shapiro E, Kandel ER (1986a): Presynaptic inhibition produced by an identified presynaptic inhibitory neuron. I. Physiological mechanisms. J Neurophysiol 55:113–130
Kretz R, Shapiro E, Bailey CH, Chen M, Kandel ER (1986b): Presynaptic inhibition produced by an identified presynaptic inhibitory neuron. II. Presynaptic conductance changes caused by histamine. J Neurophysiol 55:131–146
Kuno M (1964): Mechanism of facilitation and depression of the excitatory synaptic potential in spinal motoneurones. J Physiol (Lond) 175:100–112
Legido A, Reichlin S, Dichter MA, Buchhalter J (1990): Expression of somatostatin and GABA immunoreactivity in cultures of rat hippocampus. Peptides 11:103–109
Lester RAJ, Jahr CE (1990): Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons. Neuron 4:741–749
Liddell EGT, Sherrington CS (1925): Further observations on myotatic reflexes. Proc Roy Soc B 97:261–283
Lipscombe D, Kongsamut S, Tsien RW (1989): α-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium channel gating. Nature 340:637–642
Llinas R, Gruner JA, Sugimori M, McGuinness TL, Greengard P (1991): Regulation by synapsin I and Ca2+-calmodulin-dependent protein kinase II of transmitter release in squid giant synapse. J Physiol (Lond) 436:257–282
Man-Son-Hing H, Zoran MJ, Lukowiak K, Haydon PG (1989): A neuromodulator of synaptic transmission acts on the secretory apparatus as well as on ion channels. Nature 341:237–239
Marchetti C, Carbone E, Lux HD (1986): Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick. Pflugers Arch 406:104–111
Miller RJ (1990): Receptor-mediated regulation of calcium channels and neurotransmitter release. FASEB J 4:3291–3299
Nelson PG, Marshall KC, Pun RYK, Christian CN, Sheriff WH, MacDonald RL, Neale EA (1983): Synaptic interactions between mammalian central neurons in cell culture. II. Quantal analysis of EPSPs. J Neurophysiol 49:1442–1458
Nicoli RA (1988): The coupling of neurotransmitter receptors to ion channels in the brain. Science 241:545–551
Nicoli RA, Alger BE (1979): Presynaptic inhibition: transmitter and ionic mechanisms. Int Rev Neurobiol 21:217–258
Nicoli RA, Malenka RC, Kauer JA (1990): Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Phys Rev 70:513–565
North RA (1989): Drug receptors and the inhibition of nerve cells. Br J Pharmacol 98:13–28
Peng Y-Y, Frank E (1989): Activation of GABAB receptors causes presynaptic inhibition at synapses between muscle spindle afferents and motoneurons in the spinal cord of bullfrogs. J Neurosci 9:1502–1515
Peng Y-Y, Horn JP (1991): Continuous repetitive stimuli are more effective than bursts for evoking LHRH release in bullfrog sympathetic ganglia. J Neurosci 11:85–95
Scholz KP, Geary LJ, Byrne JH (1988): Inositol 1,4,5-trisphosphate alters bursting pacemake activity in Aplysia neurons: voltage-clamp analysis of effects on calcium currents. J Neurophysiol 60:86–104
Scholz KP, Miller RJ (1992): Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses. Neuron 8:1139–1150
Segev I (1990): Computer study of presynaptic inhibition controlling the spread of action potentials into axonal terminals. J Neurophysiol 63:987–998
Silinsky EM (1981): On the calcium receptor that mediates depolarization-secretion coupling at cholinergic motor nerve terminals. Br J Pharmacol 73:413–429
Silinsky EM (1984): On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings. J Physiol (Lond) 346:243–256
Smith SJ, Augustine GJ (1988): Calcium ions, active zones and synaptic transmitter release. Trends in Neurosci 11:458–464
Soejima M, Noma A (1984): Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells. Pflugers Arch 400:424–431
Somogyi P, Hodgson AJ, Smith AD, Nunzi MG, Gorio A, Wu JY (1984): Different populations of GABAergic neurons in the visual cortex and hippocampus of cat contain somatostatin- or cholesystokinin-immunoreactive material. J Neurosci 4:2590–2603
Stanley E, Cox C (1991): Calcium channels in the presynaptic nerve terminal of the chick ciliary ganglion giant synapse. Ann NY Acad Sci 635:70–79
Starke K, Gothert M, Kilbinger H (1989): Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol Rev 69:864–989
Stjarne L, Msghina M, Stjarne E (1990): “Upstream” regulation of the release probability in sympathetic nerve varicosities. Neuroscience 36:571–587
Stuart GJ, Redman SJ (1992): The role of GABAA and GABAB receptors in presynaptic inhibition of Ia EPSPs in cat spinal motoneurones. J Physiol (Lond) 447:675–692
Takeuchi A, Takeuchi N (1966): A study of the inhibitory action of gamma-aminobutyric acid on neuromuscular transmission in the crayfish. J Physiol (Lond) 183:418–432
Ullrich S, Wollheim CB (1988): GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. J Biol Chem 263:8615–8620
VanDongen AMJ, Codina J, Olate J, Mattera R, Joho R, Birnbaumer L, Brown A (1988): Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science 242:1433–1437
Von Kugelgen I, Starke K (1991): Noradrenaline-ATP co-transmission in the sympathetic nervous system. Trends Pharm Sci 12:319–323
Waziri R, Kandel ER, Frazier WT (1969): Organization of inhibition in abdominal ganglion of Aplysia. II. Posttetanic potentiation, heterosynaptic depression, and increments in frequency of inhibitory postsynaptic potentials. J Neurophysiol 32:509–519
Whim MD, Lloyd PE (1989): Frequency-dependent release of peptide cotransmitters from identified cholinergic motor neurons in Aplysia. Proc Natl Acad Sci USA 86:9034–9038
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Scholz, K.P. (1993). Introductory Perspective. In: Dunwiddie, T.V., Lovinger, D.M. (eds) Presynaptic Receptors in the Mammalian Brain. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6825-0_1
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