In Vivo Gene Transfer into the Heart

  • Jeffrey M. Leiden
  • Eliav Barr


The expression of recombinant genes in the human coronary arteries and myocardium holds promise for the treatment of a number of inherited and acquired cardiovascular diseases. These include the cardiomyopathy associated with Duchenne Muscular Dystrophy (DMD) (For review, Perloff, 1992), the problem of restenosis following balloon angioplasty of the coronary arteries (For review, Safian et al., 1992) and syndromes of chronic myocardial ischemia (For review, Rutherford and Braunwald, 1992). Current approaches to somatic gene therapy can be divided into two general categories: Ex vivo gene transfer involves the removal of cells from an organism followed by gene transduction in vitro and reimplantation of the genetically modified cells into the appropriate tissue in vivo. In contrast, in vivo gene transfer involves the introduction of a recombinant gene into the appropriate cell type in vivo without the need to remove and culture cells from the recipient organism.


Gene Transfer Cardiac Myocytes Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Galactosidase Activity 
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© Birkhäuser Boston 1994

Authors and Affiliations

  • Jeffrey M. Leiden
  • Eliav Barr

There are no affiliations available

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