Gene Therapy: The Advent of Adenovirus

  • Leslie D. Stratford-Perricaudet
  • Michel Perricaudet


Adenovirus has been developed as an alternative gene transfer vehicle which has emerged as a potent vector with a promising future. Infection of cells with replication-incompetent adenoviruses allows the production of foreign proteins encoded by the engineered viruses without otherwise affecting the host cell. Of utmost relevance to gene therapy, postmitotic cells seem particularly adapted to gene transfer by adenovirus, since the viral genome is not integrated into the cell’s chromosome and presumably persists the life of the cell. Administration of recombinant adenoviruses directly in vivo opens the way to new therapeutic strategies. The first successful somatic gene therapy of a hepatic enzyme deficiency in an animal model was achieved using an adenovirus (Stratford-Perricaudet et al., 1990). Since this initial demonstration of the feasibility of correcting a genetic defect with adenovirus, many potential applications have been imagined. The field has aroused much enthousiasm as reflected at the December 1992 RAC meeting where approval was given to carry out clinical trials using three different recombinant adenoviruses capable of expressing the human CFTR, one of which was constructed in our laboratory (Rosenfeld et al., 1992).


Cystic Fibrosis Gene Therapy Cystic Fibrosis Transmembrane Conductance Regulator Duchenne Muscular Dystrophy Recombinant Adenovirus 


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Copyright information

© Birkhäuser Boston 1994

Authors and Affiliations

  • Leslie D. Stratford-Perricaudet
  • Michel Perricaudet

There are no affiliations available

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