Development of Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System

  • Joseph C. Glorioso
  • Neal A. DeLuca
  • William F. Goins
  • David J. Fink


Advances in understanding the molecular basis of human disease in the past decade have led to the identification and cloning of genes responsible for certain heritable diseases of the central nervous system (CNS) as well as many of those encoding neurotransmitters, receptors, and growth factors which influence brain function. For example, the genes responsible for the neurodegenerative diseases amyotrophic lateral sclerosis (Rosen et al., 1993) and Huntington’s chorea (Goldberg, et al., 1993; Mac Donald et al., 1993) have recently been identified. Ongoing research promises to identify the genes primarily responsible for other more complex neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Currently, many neurodegnerative diseases are not treatable. Even in cases where therapies exist, drugs which control symptoms may ultimately fail in the late stages of neurological disease in a considerable percentage of affected patients. For example, the administration of L-DOPA to Parkinson’s patients may even accelerate the decline in dopamine producing neurons. Other difficulties with traditional therapies are that the blood-brain barrier limits the delivery of systemically administered drugs into the brain parenchyma, and even drugs delivered by intraventricular injection penetrate poorly from the ventricular surface into the substance of the brain. Empediments to drug delivery and bioavailability are further complicated by the regional and cellular specialization that is characteristic of the brain. Direct targeting of the therapeutic product to specific brain regions or to cells within those regions may be required to overcome these limitations.


Herpes Simplex Herpes Simplex Virus Type Trigeminal Ganglion Foreign Gene Foreign Gene Expression 


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© Birkhäuser Boston 1994

Authors and Affiliations

  • Joseph C. Glorioso
  • Neal A. DeLuca
  • William F. Goins
  • David J. Fink

There are no affiliations available

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