Gene Therapy for Adenosine Deaminase Deficiency and Malignant Solid Tumors
Gene therapy may be considered the ultimate treatment for genetic diseases (Anderson, 1984). The possibility of reversing genetic defects by replacing the defective gene instead of merely treating symptoms is very appealing. Significant progress in the development of clinical applications of gene therapy has occurred. More than 40 human gene transfer and therapy experiments have been initiated since the introduction of this approach in 1989 (Anderson, 1992; Miller, 1992).
KeywordsGene Therapy Adenosine Deaminase Bystander Effect Purine Nucleoside Phosphorylase Primary Immunodeficiency Disease
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