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Virus-Mediated Genetic Treatment of Rodent Gliomas

  • E. Antonio Chiocca
  • Julie K. Andersen
  • Yoshiaki Takamiya
  • Robert L. Martuza
  • Xandra O. Breakefield

Abstract

The most common primary central nervous system neoplasm in adults is the malignant glioma. Approximately 5,000 new cases are diagnosed annually in the United States. This tumor has proven to be extremely refractory to currently available therapeutic modalities. A combination of aggressive surgical excision, radiation therapy, and chemotherapy has increased the life expectancy of patients suffering from this illness by only a few months (Schoenberg, 1983; Salcman, 1985; Kornblith et al., 1985). Sometimes the aggressive pursuit of these therapeutic modalities results in considerable neurologic dysfunction.

Keywords

Glioma Cell Herpes Simplex Virus Type Thymidine Kinase Primary Central Nervous System Neoplasm Ganciclovir Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Boston 1994

Authors and Affiliations

  • E. Antonio Chiocca
  • Julie K. Andersen
  • Yoshiaki Takamiya
  • Robert L. Martuza
  • Xandra O. Breakefield

There are no affiliations available

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