A History of Gene Transfer and Therapy

  • Jon A. Wolff
  • Joshua Lederberg


“Gene therapy” is generally thought of as a very new concept, but the notion that genes could be manipulated to treat human disease actually goes back several decades. Many of the pioneers of modern genetics realized that their discoveries eventually could lead to medical applications. Some even proposed gene transfer approaches decades ago that are still being explored today.


Gene Therapy Thymidine Kinase Deoxyribonucleic Acid Arginase Activity Rous Sarcoma Virus 
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  1. Alexander HE, Koch G, Mountain IM, Sprunt K, Van Damme O (1958): Infectivity of ribonucleic acid of polio virus on He La cell monolayers. Virology 5: 172–173PubMedCrossRefGoogle Scholar
  2. Amos H (1961): Protamine enhancement of RNA uptake by cultured chick cells. Biochem Biophys Res Comm 5: 1–4CrossRefGoogle Scholar
  3. Anderson WF, Fletcher JC (1980): Gene therapy in human beings: when is it ethical to begin? N Eng J Med 303 (22): 1293–1297CrossRefGoogle Scholar
  4. Anderson WF, Killos L, Sanders-Haigh L, Kretschmer PJ, Diacumakos EG (1980): Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts. Proc Natl Acad Sci USA 77 (9): 5399–5403PubMedCrossRefGoogle Scholar
  5. Aposhian HV (1970): The use of DNA for gene therapy—the need, experimental approach, and implications. Perspectives in Biology and Medicine 14: 987–108Google Scholar
  6. Aposhian HV, Qasba PK, Osterman JV, Waddell A (1972): Polyoma pseudovirions: an experimental model for the develpment of DNA for gene therapy. Federation Proceedings 31 (4): 1310–1325PubMedGoogle Scholar
  7. Aposhian HV, Qasba PK, Osterman JV, Waddell A (1972): Polyoma pseudovirions: an experimental model for the develpment of DNA for gene therapy. Federation Proceedings 31 (4): 1310–1325PubMedGoogle Scholar
  8. Avery OT, MacLeod CM, McCarty M (1944): Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Journal of Experimental Medicine 79: 137–158PubMedCrossRefGoogle Scholar
  9. Azrin NH (1961): Incorporation of heterologous deoxyribonucleic acid into mammalian cells. Science 133: 381–383CrossRefGoogle Scholar
  10. Bacchetti S, Gaham FL (1977): Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by prurified herpes simplex viral DNA. Proc Natl Acad Sci USA 74 (4): 1590–1594PubMedCrossRefGoogle Scholar
  11. Baltimore D (1970): Viral RNA-dependent DNA polymerase. Nature 226: 1209–1211PubMedCrossRefGoogle Scholar
  12. Beam JG, Kirby KS (1961): Failure of deoxyribonucleic acid to produce pigment changes in the albino rat. Exp Cell Res 17: 547–549Google Scholar
  13. Benoit J, Leroy P, Vendrely R, Vendrely C (1960): Experiments on pekin ducks treated with DNA from khaki Campbell ducks. Transaction of The New York Academy of Sciences 22: 494–503Google Scholar
  14. Benoit J, Leroy P,Vendrely R, Vendrely C (1960): Modifications de caracteres raciaux du canard pekin par Tacide desoxyribonucleique de canard khaki cambell et leur transmission a la descendance. Biochemical Pharmacology 4: 181–194CrossRefGoogle Scholar
  15. Bensch KG, King DW (1961): Incorporation of heterologous deoxyribonucleic acid into mammalian cells. Science 133: 381–382PubMedCrossRefGoogle Scholar
  16. Benvenisty N, Reshef L (1986): Direct introduction of genes into rats and expression of the genes. Proc Natl Acad Sci USA 83: 9551–9555PubMedCrossRefGoogle Scholar
  17. Borenfreund E, Bendich A (1961): A study of the penetration of mammalian cells by deoxyrobonucleic acids. The Journal of Biophysical and Biochemical Cytology 9: 81–91PubMedCrossRefGoogle Scholar
  18. Boyd JSK, Portnoy B (1944): Bacteriophage therapy in bacillary dysentery. Trans R Soc Trop Med Hyg 37: 243–262CrossRefGoogle Scholar
  19. Bradley TR, Roosa RA, Law LW (1962): DNA transformation studies with mammalian cells in culture. Journal of cellular and comparative physiology 60: 127–138PubMedCrossRefGoogle Scholar
  20. Burnett JP, Harrington JA (1968): Infectivity associated with Simian Adenovirus Type SA7 DNA. Nature 220: 1245PubMedCrossRefGoogle Scholar
  21. Cline MJ, Stang H, Mercola K, Morse L, Ruprecht R, Browne J, Salser W (1980): Gene transfer in intact animals. Nature 284: 422–5PubMedCrossRefGoogle Scholar
  22. Cocito C, Prinzie A, De Somer P (1962): Uptake by mammalian cells of nucleic acids combined with a basic protein. Experientia 18: 218–220PubMedCrossRefGoogle Scholar
  23. Cold Spring Harbor Laboratory (1983): Gene Therapy: Fact and Fiction. Cold Spring Harbor, NY: Cold Spring Harbor LaboratoryGoogle Scholar
  24. Colter JS, Bird HH, Moyer AW, Brown RA (1957): Infectivity of ribonucleic acid isolated from virus-infected tissues. Virology 4: 522–532PubMedCrossRefGoogle Scholar
  25. Colter JS, Ellem KAO (1961): Interaction of viral nucleic acids with mammalian cells. Federation Proceedings 20: 650–655PubMedGoogle Scholar
  26. Cooper GM, Okenquist S, Silverman L (1980): Transforming activity of DNA of chemically transformed and normal cells. Nature 284: 418–421PubMedCrossRefGoogle Scholar
  27. Crow JF (1992): Anecdotal, Historical and Critical Commentaries on Genetics. Genetics 131: 761–768PubMedGoogle Scholar
  28. Cushman DW, Ondetti MA (1991): History of the design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension 17 (4): 589–592PubMedGoogle Scholar
  29. d’Herelle F (1926): The bacteriophage and its behavior. (Smith GH, Trans.). Paris: BalliereCrossRefGoogle Scholar
  30. Davis BD (1970): Prospects for Genetic Intervention in Man. Science q170: 1279–1283PubMedCrossRefGoogle Scholar
  31. DiMayorca GA, Eddy BE, Stewart SE, Hunter WS, Friend C, Bendich A (1959): Isolation of infectious deoxyribonucleic acid from SE polyoma-infected tissue cultures. Proc Natl Acad Sci USA 45: 1805–1808PubMedCrossRefGoogle Scholar
  32. Djordjevic O, Kostic L, Kanazir D (1962): Recovery of ultra-violet-irradiated L strain cells by means of highly polymerized deoxyribonucleic acid. Nature 195: 614–615PubMedCrossRefGoogle Scholar
  33. Doehmer J, Barinaga M, Vale W, Rosenfeld MG, Verma IM, Evans RM (1982): Introduction of rat growth hormone gene into mouse fibroblasts via a retorviral DNA vector: Expression and regulation. Proc Natl Acad Sci USA 79: 2268–2272PubMedCrossRefGoogle Scholar
  34. Dubensky TW, Campbell BA, Villarreal LP (1984): Direct transfection of viral and plasmid DNA into the liver or spleen of mice. Proc Natl Acad Sci USA 81: 7529–7533PubMedCrossRefGoogle Scholar
  35. Dubes GR, Klingler EA (1961): Facilitation of Infection of Monkey Cells with Poliovirus “Ribonucleic Acid”. Science 133: 99–133PubMedCrossRefGoogle Scholar
  36. Fahmy OG, Fahmy MJ (1961): Induction of mutations by deoxyribonucleic acid in Drosophila melanogaster. Nature 191: 776–779PubMedCrossRefGoogle Scholar
  37. Farber FE, Melnick JL, Butel JS (1975): Optimal conditions for uptake of exogenous DNA by Chinese hamster lung cells deficient in hypoxanthine-guanosine phosphoribosyltransferase. Biochim Biophys Acta 390: 298–311PubMedGoogle Scholar
  38. Feigner PL (1990): Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides. Advanced Drug Delivery Reviews 5: 163–187CrossRefGoogle Scholar
  39. Floersheim GL (1962): System for the recognition of genetic transformation in haemopoietic cells. Nature 193: 1266–1268CrossRefGoogle Scholar
  40. Fournier REK, Ruddle FH (1977): Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells. Proc Natl Acad Sci USA 74 (1): 319–323PubMedCrossRefGoogle Scholar
  41. Frederic J, Corin-Frederic J (1962): Modifications des chromosomes et du caryotype dans des cellules de Poulet cultivees in vitro en presence d’acides desoxyribonucleiques de veau. CR Soc Biol 156: 742–745Google Scholar
  42. Friedmann T (1971): In vitro reassembly of shell-like particle from disrupted polyoma virus. Proc Natl Acad Sci USA 68 (10): 2574–2578PubMedCrossRefGoogle Scholar
  43. Friedmann T (1976): The future for gene therapy—a réévaluation. Annals New York Academy of Science 265: 141–152CrossRefGoogle Scholar
  44. Friedmann T (1989): Progress toward human gene therapy. Science 244: 1275–1281PubMedCrossRefGoogle Scholar
  45. Friedmann T (1990): The Evolving Concept of Gene Therapy. Human Gene Therapy 1: 175–181PubMedCrossRefGoogle Scholar
  46. Friedmann T (1992): Abrief history of gene therapy. Nature genetics 2 (october): 93–98PubMedCrossRefGoogle Scholar
  47. Friedmann T, Roblin R (1972): Gene therapy for human genetic disease? Science 175 (4025): 949–955PubMedCrossRefGoogle Scholar
  48. Gartier SM (1959): Cellular uptake of deoxyribonucleic acid by human tissue culture cells. Nature 184: 1505–1506CrossRefGoogle Scholar
  49. Gartier SM (1960): Demonstration of cellular uptake of polymerized DNA in mammalian cell cultures. Biochem Biophys Res Comm 3: 127–131CrossRefGoogle Scholar
  50. Goff SP, Berg P (1976): Construction of hybrid viruses containing SV40 and gamma phage DNa segments and their propagation in cultured monkey cells. Cell 9: 695–705PubMedCrossRefGoogle Scholar
  51. Goodman LS, Gilman A (Ed.). (1975): The Pharmacologic Basis of Therapeutics. New York: Macmillan Publishing CoGoogle Scholar
  52. Graessmann M, Graessmann A (1976): “Early” simian-virus-40-specific RNA contains information for tumor antigen formation and chromatin replication. Proc Natl Acad Sci USA 73:366–370Google Scholar
  53. Graf BH, Urlaub G, Chasin LA (1979): Transformation of the gene for hypoxanthine phophoribosyltransferase. Somatic Cell Genetics 5 (6): 1031–1044PubMedCrossRefGoogle Scholar
  54. Graham FL, Van Der Eb AJ (1973): A New technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52: 456–467PubMedCrossRefGoogle Scholar
  55. Graham FL, Van der Eb AJ, Heijneker HL (1974): Size and location of the transforming region in human adenovirus type 5 DNA. Nature 251: 687–90PubMedCrossRefGoogle Scholar
  56. Green MR, Treisman R, Maniatis T (1983): Transcriptional Activation of Cloned Human Beta-Globin Genes by Viral Immediate-Early Gene Products. Cell 35: 137–148PubMedCrossRefGoogle Scholar
  57. Hamer DH, Davoli D, Thomas CA, Fareed GC (1977): Simian virus 40 carrying an Escherichia coli Suppressor Gene. Journal of Molecular Biology 112: 155–182PubMedCrossRefGoogle Scholar
  58. Hamer DH, Leder P (1979): Expression of the chromosomal mouse βmaj-globin gene cloned in SV40. Nature 281: 35–40PubMedCrossRefGoogle Scholar
  59. Hamer DH, Smith KD, Boyer SH, Leder P (1979): SV 40 Recombinants Carrying Rabbit bet-Globin Gene Coding Sequences. Cell 17: 725–735PubMedCrossRefGoogle Scholar
  60. Haskova V, Hrubesova M (1958): Part played by deoxyribonucleic acid in transplantation immunity. Nature 182: 61–62PubMedCrossRefGoogle Scholar
  61. Herriott RM (1961): Infectious nucleic acids, a new dimension in virology. Science 134: 256–260PubMedCrossRefGoogle Scholar
  62. Hershey AD, Burgi E (1965): Complementary structure of interacting sites at the ends of lambda DNA molecules. Proc Natl Acad Sci USA 53: 325–328PubMedCrossRefGoogle Scholar
  63. Hill M (1961): Uptake of deoxyribonucleic acid (DNA): a special property of the cell nucleus. Nature 189: 916–917PubMedCrossRefGoogle Scholar
  64. Hill M, Hillova J (1972): Virus Recovery in chicken Cells tested with Rous Sarcoma Cell DNA. Nature New Biology 237: 35–39PubMedGoogle Scholar
  65. Hill M, Huppert J (1970): Fate of exogenous mouse DNA in chicken fibroblasts in vitro non-conservative preservation. Biochimica and Biophysica Acta 213: 26–35Google Scholar
  66. Hill M, Jakubickova J (1962): Intercellular passage of DNA as revealed in bone marrow autoradiographs. Exp Cell Res 26: 541–551PubMedCrossRefGoogle Scholar
  67. Holland JJ, Hoyer BH, McLaren LC, Syverton JT (1960): Enteroviral ribonucleic acid. I—Recovery from virus and assimilation by cells. J Exp Med 112: 821–864PubMedCrossRefGoogle Scholar
  68. Holoubek V, Hnilica L (1961): The failure to produce somatic and immunologic changes in inbred AKR mice by specific deoxyribonocleic acid. Can J Biochem Physio 39: 1478–1479CrossRefGoogle Scholar
  69. Hudnik-Plevnik T, Glisin VR, Simic MM (1959): Fate of the highly polymerized spleen deoxyribonucleic labelled with Phosphorus-32 injected intraperitoneally into rats. Nature 184: 1818–1819PubMedCrossRefGoogle Scholar
  70. Ito Y (1960): A tumor-producing factor extracted by phenol from papillomatous tissue (Shope) of Cottontail Rabbits. Virology 12: 596–601PubMedCrossRefGoogle Scholar
  71. Ito Y (1961): Heat-resistance of the tumorigenic nucleic acids of Shope papillomatosis. Proc Natl Acad Sci USA 47: 1897–1900PubMedCrossRefGoogle Scholar
  72. Jackson DA, Symon RH, Berg P (1972): Biochemical method for inserting new genetic information into DNA of Simian Virus 40: Circular SV40 DNA molecules containing lambda phage genes and the galactose peron of Escherichia coli. Proc Natl Acad Sci USA 69 (10): 2904–2909PubMedCrossRefGoogle Scholar
  73. Judson HF (1979): The Eighth Day of Creation: The makers of the revolution in biology. New York: Simon and Schuster.Google Scholar
  74. Kaneda Y, Iwai K, Uchida T (1989): Increased Expressio of DNA cointroduced with nuclear Protein in adult rat liver. Science 243: 375–377PubMedCrossRefGoogle Scholar
  75. Kantoch M, Bang FB (1962): Conversion of genetic resistance of mammalian cells to susceptibility to a virus infection. Proc Natl Acad Sci USA 48: 1553–1559PubMedCrossRefGoogle Scholar
  76. Kao F-T, Puck TT (1968): Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells. Proc Natl Acad Sci USA 60: 1275–1281PubMedCrossRefGoogle Scholar
  77. Kay ERM (1961): Incorporation of Deoxyribonucleic Acid by mammalian cells in vitro. Nature 191: 387–388PubMedCrossRefGoogle Scholar
  78. Keating A, Toneguzzo F (1990). Gene tranfer by electroporation: a model for gene therapy. In S. Gross,A. P. Gee, D. A. Worthington-White (Eds.), Bone Marrow Purging and Processing, (pp. 491–498 ). New Yord: Wiley-LissGoogle Scholar
  79. Klein G (1952): The nature of mammalian lymphosarcoma transmission by isolated chromatin fractions. Cancer Research 12: 589–590PubMedGoogle Scholar
  80. Klingler E, Chapin M, Dubes GR (1959): Relationship between inactivation of poliovirus by phenol and appearance of ribonuclease-labile infectivity. Proc Soc Exp Biol Med 101: 829–832PubMedGoogle Scholar
  81. Kobernick SD, Toovey EW, Webster DR (1952): Effects of the Application of Carcinogens to exposed gastric mucosa in the rat. Cancer Research 12: 591–593PubMedGoogle Scholar
  82. Koch G, Koenig S, Alexander H (1960): Quantitative studies on the infectivity of ribonucleic acid from partially purified and highly purified poliovirus preparations. Virology 10: 329–343PubMedCrossRefGoogle Scholar
  83. Kraus L (1961): Formation of different haemoglobins in tissue culture of human bone marrow treated with human deoxyribonucleic acid. Nature 192: 1055–1057PubMedCrossRefGoogle Scholar
  84. Lederberg J (1956): Genetic transduction. American Scientist 44: 264–280Google Scholar
  85. Lederberg J (1973): The genetics of human nature. Social Res 40: 375–406PubMedGoogle Scholar
  86. Leuchtenberger C, Leuchtenberger R, Uyeki E (1958): Cytological and cytochemical changes in livers of white mice following intraperitoneal injections of DNA preparations from breast cancers of Agouti C3H mice. Proc Natl Acad Sci USA 44: 700–705PubMedCrossRefGoogle Scholar
  87. Levine F, Friedmann T (1991): Gene therapy techniques. Current Opinion in Biotechnology 2: 840–844PubMedCrossRefGoogle Scholar
  88. Lewis W, Srinivasan PR, Stokoe N, Siminovitch L (1980): Parameters governing the transfer of the genes for thymidine kinase and dihydrofolate reductase into mouse cells using metaphase chromosomes or DNA. Somatic Cell Genetics 6 (3): 333–347PubMedCrossRefGoogle Scholar
  89. Linnane AW, Lamb AJ, Christodoulou C, Lukins HB (1967): The biogenesis of mitochondria, VI. Biochemical basis of the resistance of saccharomyces cerevisiae toward antibiotics which specifically inhibit mitochondrial protein synthesis. Proc Natl Acad Sci USA 59: 1288–1293CrossRefGoogle Scholar
  90. Lwoff A (1972). Interaction among virus, cell, and organism: Nobel lecture, December 11, 1965. In Nobel Lectures in Physiology or Medicine, 1963–1970 (pp. 174–185 ). New York: ElsevierGoogle Scholar
  91. Maitland NJ, McDougall JK (1977): Biochemical transformation of Mouse Cells by Fragments of Herpes Simplex Virus DNA. Cell 11: 233–241PubMedCrossRefGoogle Scholar
  92. Mandel M, Higa A (1970): Calcium-dependent bacteriophage DNA Infection. Journal of Molecular Biology 53: 159–162PubMedCrossRefGoogle Scholar
  93. Maniatis T, Kee SG, Efstratiadis A, Kafatos FC (1976): Amplification and characterization of a Beta-Globin Gene Synthesized in vitro. Cell 8: 163–182PubMedCrossRefGoogle Scholar
  94. Mannino RJ, Gould-Fogerite S (1988): Liposome Meidated Gene transfer. Bio Techniques 6 (7): 682–90Google Scholar
  95. Martinovitch PN, Kanazir DT, Knezevitch ZA, Simitch MM (1962): Teratological changes in the offspring of chicken embryos treated with tyrode or with tyrode plus DNA. J Embryol Exp Morph 10: 167–177PubMedGoogle Scholar
  96. Mathias AP, Fischer GA (1962): Transformation experiments with murine lymphoblastic cells (L5178Y) grown in culture. Biochemical Pharm 11: 69–78CrossRefGoogle Scholar
  97. McCutchan JH, Pagano JS (1968): Enhancement of the infectivity of Simian Virus 40 Deoxyribonucleic Acid with Diethylaminoethyl-Dextran. Journal of the National Cancer Institute 41 (2): 351–357PubMedGoogle Scholar
  98. Medawar (1958): Part played by deoxyribonucleic acid in transplantation immunity. Nature 182: 62CrossRefGoogle Scholar
  99. Meek ES, Hewer TF (1959): An intestinal carcinoma in mice following injection of herring-sperm deoxyribonucleic acid. Brit J Cancer 13: 121–125PubMedCrossRefGoogle Scholar
  100. Mercola KE, Stang HD, Browne J, Salser W, Cline MJ (1980): Insertion of a new gene of viral origin into bone marrow cells of mice. Science 208: 1033–1035PubMedCrossRefGoogle Scholar
  101. Miller A, Rosman G (1989): Improved retoviral vectors for gene transfer and expression. Bio Techniques 7 (9): 980–990Google Scholar
  102. Miller AD (1992): Human gene therapy comes of age. Nature 357: 455–60PubMedCrossRefGoogle Scholar
  103. Miller AD, Law M-F, Verma EM (1985): Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene. Molecular and Cellular Biology 5 (3): 431–437PubMedGoogle Scholar
  104. Minson AC, Wildy P, Buchan A, Darby G (1978): Introduction of the Herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA. Cell 13: 581–587PubMedCrossRefGoogle Scholar
  105. Morrow JF (1976): The prospects for gene therapy in humans. Annals of the New York Academy of Sciences 265: 13–21PubMedCrossRefGoogle Scholar
  106. Mountain IM, Alexander HE (1959): Infectivity of ribonucleic acid (RNA) from type I poliovirus in embryonated egg. Proc Soc Exp Biol Med 101: 527–532PubMedGoogle Scholar
  107. Mulligan RC, Berg P (1980): Expression of a bacterial Gene in mammalian Cells. Science 209: 1422–1427PubMedCrossRefGoogle Scholar
  108. Mulligan RC, Berg P (1981): Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Proc Natl Acad Sci USA 78: 2072–2076PubMedCrossRefGoogle Scholar
  109. Mulligan RC, Berg R (1981): Factors Governing the Expression of a bacterial Gene in Mammalian Cells. Molecular and Cellular Biology 1 (5): 449–459PubMedGoogle Scholar
  110. Mulligan RC, Howard B, Berg P (1979): Synthesis of rabbit beta-globin in cultured monkey kidney cells following infection with a SV40 beta-globin recombinant genome. Nature 277: 108–114PubMedCrossRefGoogle Scholar
  111. Munyon W, Kraiselburd E, Davis D, Mann J (1971): Transfer of thymidine kinase to thymidine kinaseless L cells by infection with Unltraviolet-irradiated herpes simplex virus. Journal of Virology 7 (6): 813–820PubMedGoogle Scholar
  112. Neville R (1976): Gene therapy and the ethics of genetic therapeutics. Annals of the New York Academy of Sciences 265: 153–169PubMedCrossRefGoogle Scholar
  113. Nicolau C, Le Pape A, Soriano P, Fargette F, Juhel M-F (1983): In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I. Proc Natl Acad Sci USA 80: 1068–1072PubMedCrossRefGoogle Scholar
  114. Nicolson MO, McAllister RM (1972): Infectivity of Human Adenovirus-1 DNA. Virology 48: 14–21PubMedCrossRefGoogle Scholar
  115. Orth G, Vielle F, Changeux JP (1967): On the arginase of the shope papillomas. Virology 31: 729–32PubMedCrossRefGoogle Scholar
  116. Paschkis KE, Cantarow A, Stansney J (1955): Induction of neoplasms by injection of tumor chromatin. Journal of the National Cancer Institute 15 (5): 1525–1532PubMedGoogle Scholar
  117. Pellicer A, Robins D, Wold B, Sweet R, Jackson J, Lowy I, Roberts JM, Sim GK, Silverstien S, Axel R (1980): Altering genotype and phenotype by DNA-me- diated gene transfer. Science 209: 1414–1422PubMedCrossRefGoogle Scholar
  118. Perry TL, Walker D (1958): Failure of deoxyribonucleic acid to effect somatic transformation in the rat. Proc Soc Exp Biol Med 99: 717–720PubMedGoogle Scholar
  119. Perutz M (1992): Protein Structure: New approaches to disease and therapy. New York: W.H. Freeman and Co.Google Scholar
  120. Philipson L, Lonberg-Holm K, Pettersson U (1968): Virus-receptor interaction in an adenovirus system. Journal of Virology 2 (10): 1064–1075PubMedGoogle Scholar
  121. Publication N (1971). The prospects of Gene Therapy. In E. Freese (Ed.), Fogarty International Center, Bethesda, Maryland: DHEW PublicationGoogle Scholar
  122. Rabotti GF (1963): Incorporation of DNA into a mouse tumor in vivo and in vitro. Experimental Cell Research 31: 562–565PubMedCrossRefGoogle Scholar
  123. Reynaud A, Cloastre L, Bernard J, Laveran H, Ackermann H-W, Licois D, Joly B (1992): Characteristics and diffusion in the rabbit of a phage for escherichia coli 0103. Attempts to use this phage for therapy. Vet Microbiol 30: 203–212PubMedCrossRefGoogle Scholar
  124. Rieke WO (1962): The in vivo reutilization of lymphocytic and sarcoma DNA by cells growing in the peritoneal cavity. J Cell Biol 13: 205–216PubMedCrossRefGoogle Scholar
  125. Rogers S (1959): Induction of arginase in rabbit epithelium by the Shope rabbit papilloma virus. Nature 183: 1815–1816PubMedCrossRefGoogle Scholar
  126. Rogers S, Lowenthal A, Terheggen HG, Columbo JP (1973): Induction of arginase activity with the shope papilloma virus in tissue culture cells from an argininemic patient. Journal of Experimental Medicine 137: 1091–1096PubMedCrossRefGoogle Scholar
  127. Rogers S, Moore M (1963): Studies of the mechanism of action of the shope rabbit papilloma virus. I. Concerning the nature of the induction of arginase in the infected cells. J Exp Med 117: 521–542PubMedCrossRefGoogle Scholar
  128. Rogers S, Pfuderer P (1968): Use of viruses as carriers of added genetic information. Nature 219: 749–751PubMedCrossRefGoogle Scholar
  129. Rothberg S, Van Scott EJ (1961): Localization of Arginase in Rabbit Skin. Nature 189: 832–833PubMedCrossRefGoogle Scholar
  130. Sambrook J, Westphal H, Srinivasan PR, Dulbecco R (1968): The integrated state of viral DNA in SV40-transformed cells. Proc Natl Acad Sci USA 60: 1288–1295PubMedCrossRefGoogle Scholar
  131. Scangos G, Ruddle FH (1981): Mechanisms and applications of DNA-mediated gene transfer in mammalian cells-a review. Gene 14: 1–10PubMedCrossRefGoogle Scholar
  132. Schimizu T, Koyama S, Iwafuchi M (1962): Nuclear uptake of deoxyribonucleic acid by Ehrlich ascites-tunor cells. Biochim Biophys Acta 55: 795–798CrossRefGoogle Scholar
  133. Seegmiller JE, Rosenbloom FM, Kelley WN (1967): Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science 155: 1682–1685PubMedCrossRefGoogle Scholar
  134. Shih C, Shilo B-Z, Goldfarb MP, Dannenberg A, Weinberg RA (1979): Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci USA 76 (11): 5714–5718PubMedCrossRefGoogle Scholar
  135. Shimotohno K, Temin HM (1981): Formation of infections progeny virus after insertion of herpes simplex thymidine kinsase gene into DNA of an Avian Retrovirus. Cell 26: 67–77PubMedCrossRefGoogle Scholar
  136. Sinsheimer RL (1969): The prospect for designed genetic change. American Scientist 57 (1): 134–142PubMedGoogle Scholar
  137. Sirotnak FM, Hutchison DJ (1959): Absorption of deoxyribonucleic acid by mouse lymphoma cells. Biochim Biophys Acta 36: 246–248PubMedCrossRefGoogle Scholar
  138. Smull CE, Ludwig EH (1962): Enhancement of the plaque-forming capacity of poliovirus ribonucleic acid with basic proteins. J Bacteriol 84: 1035–1040PubMedGoogle Scholar
  139. Soothill JS (1992): Treatment of experimental infections of mice with bacteriophages. J Med Microbiol 37: 258–261PubMedCrossRefGoogle Scholar
  140. Spizizen J, Reilly BE, Evans AH (1966): Microbial transformation and transfection. Ann Rev Microbiol 20: 371–400CrossRefGoogle Scholar
  141. Stacey DW (1980): Expression of a subgenomic retroviral messenger RNA. Cell 21: 811–820PubMedCrossRefGoogle Scholar
  142. Stasney J, Cantarow A, Paschkis KE (1950): Production of neoplasms by injection of fractions of mammalian neoplasms. Cancer Research 10: 775–782PubMedGoogle Scholar
  143. Stolk A (1960): Experimental carcinoma of the intestine in the Cichlid Aequidens maroni (Steindachner) following injection of herring-sperm deoxyribonucleic acid. Naturwissenschajften 47: 88–89CrossRefGoogle Scholar
  144. Szybalska EH, Szybalski W (1962): Genetics of human cell lines, IV. DNA-mediated heritable transformation of a biochemical trait. Proc Natl Acad Sci USA 48: 2026–2034PubMedCrossRefGoogle Scholar
  145. Szybalski W (1963). DNA-mediated Genetic Transformation of Human Cell Lines. In Round Table Discussion, Poultry Breeders of America Annuel Meeting, McArdle Memorial Laboratory, UW-Madison:Google Scholar
  146. Szybalski W (1991): A forerunner of monoclonal antibodies and human gene therapy. Current Contents 34: 11Google Scholar
  147. Szybalski W (1992): Use of the HPRT gene and the HAT selection Technique in DNA-mediated transformation of mammalian cells: first steps toward developing hybridoma techniques and gene therapy. Bio Essays 14 (7): 495–500Google Scholar
  148. Tabin CJ, Hoffmann JW, Goff SP, Weinberg RA (1982): Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene. Molecular and Cellular Biology 2 (4): 426–436PubMedGoogle Scholar
  149. Tatum EL (1966): Molecular biology, nucleic acids and the future of medicine. Perspectives in Biology and Medicine 10: 19–32PubMedGoogle Scholar
  150. Temin H (1976): The DNA provirus hypothesis. Science 192: 1075–1080PubMedCrossRefGoogle Scholar
  151. Temin HM (1971): Mechanism of cell transformation by RNA tumor Viruses. Annual Review of Microbiology 25: 609–648PubMedCrossRefGoogle Scholar
  152. Temin HM, Mizutani S (1970): RNA-dependent DNA Polymerase in Virionsofrous sarcoma virus. Nature 226: 1211–1213PubMedCrossRefGoogle Scholar
  153. Terheggen HG, Lowenthal A, Lavinha F, Colombo JP, Rogers S (1975): Unsuccessful Trial of gene Replacement in arginase deficiency. The Journal of Experimental Medicine 119: 1–3Google Scholar
  154. Topp WC, Lane D, Pollack R (1981). Transformation by SV40 and polyoma virus. In J. Tooze (Eds.), DNA Tumor Viruses (pp. 205–296). Cold Spring HarborGoogle Scholar
  155. Vaheri A, Pagano JS (1965): Infectious Poliovirus RNA: a sensitive method of assay. Science 175: 434–436Google Scholar
  156. Wade N (1980): UCLA gene therapy racked by friendly fire. Science 210: 509–511PubMedCrossRefGoogle Scholar
  157. Wade N (1981): Gene therapy cought in more entaglements. Science 212: 24–25PubMedCrossRefGoogle Scholar
  158. Wade N (1981): Gene therapy pioneer draws mikadoesque rap. Science 212: 1253PubMedCrossRefGoogle Scholar
  159. Warden D, Thorne HV (1968): The infectivity of polyoma virus DNa for mouse embryo cells in the presence of Diethylaminoethyl-dextran. Journal of General Virology 3 (371-): 377Google Scholar
  160. Watson JD, Crick FHC (1954): Genetical implications of the structure of deoxyribonucleic acid. Nature 171: 737–739CrossRefGoogle Scholar
  161. Wei C-M, Gibson M, Spear PG, Scolnick EM (1981): Construction and isolation of a transmissible retrovirus containing the src Gene of harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type I. Journal of Virology 39 (3): 935–944PubMedGoogle Scholar
  162. Weil R (1961): Aquantitative assay for a subviral infective agent related to polyoma virus. Virology 14: 46–53PubMedCrossRefGoogle Scholar
  163. Weisberger AS (1962): Induction of altered globin synthesis in human immature erthrocytes incubated with ribonucleoprotein. Proc Natl Acad Sci USA 48: 68–80PubMedCrossRefGoogle Scholar
  164. Wigler M, Pellicer A, Silverstein S, Axel R (1977): Transfer of purified Herpes virus thymidine kinase gene to cultured mouse cells. Cell 11: 223–232PubMedCrossRefGoogle Scholar
  165. Wigler M, Pellicer A, Silverstein S, Axel R (1978): Biochemical Transfer of Single- Copy Eucaryotie Genes Using Total Cellular DNA as Donor. Cell 14: 725–731PubMedCrossRefGoogle Scholar
  166. Wigler M, Pellicer A, Silverstein S, Axel R, Urlaub G, Chasin L (1979): DNA- mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci USA 76: 1373–1376PubMedCrossRefGoogle Scholar
  167. Willecke K, Klomfa BM, Mierau R, Dohmer J (1979): Intraspecies transfer via total cellular DNA of the Gene for Hypoxanthine phosphoribosyltransferase into cultured mouse cells. Molecular and General Genetics 170: 179–185PubMedCrossRefGoogle Scholar
  168. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Feigner PL (1990): Direct gene transfer into mouse muscle in vivo. Science 247: 1465–1468PubMedCrossRefGoogle Scholar
  169. Zinder ND, Lederberg J (1952): Genetic exchange in Salmonella. J Bacteriology 64: 679–699CrossRefGoogle Scholar

Copyright information

© Birkhäuser Boston 1994

Authors and Affiliations

  • Jon A. Wolff
  • Joshua Lederberg

There are no affiliations available

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