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Under the Spell of the Synapse

  • John G. Eccles

Abstract

My scientific life began when, as a 17- to 18-year-old medical student in Melbourne, I became enthused by the brain-mind problem, in particular as it related to my own experienced self-consciousness. I read avidly all the philosophical and psychological texts available, and came to the conclusion that there was a plethora of dogmatism superimposed on a most inadequate scientific base. At that time it seemed to me that the specialized connections between nerve cells, the synapses, contained the clue not only to the subtlety of the nervous reactions, but even to the problems of brain and mind. I had come under the spell of the synapse!

Keywords

Nerve Cell Nerve Impulse Intracellular Recording Neuromuscular Transmission Excitatory Synapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brock, L.G., Coombs, J.S., and Eccles, J.C. (1951): Action potentials of motoneurones with intracellular electrode. Proc. Univ. Otago Med. Sch. 29:14–15.Google Scholar
  2. Brock, L.G., Coombs, J.S., and Eccles, J.C. (1952a): The recording of potentials from motoneurones with an intracellular electrode. J. Physiol. 117:431–460.PubMedGoogle Scholar
  3. Brock, L.G., Coombs, J.S., and Eccles, J.C. (1952b): The nature of the monosynaptic excitatory and inhibitory processes in the spinal cord. Proc. R. Soc. B. 140:170–176.CrossRefGoogle Scholar
  4. Brooks, C. McC., and Eccles, J.C. (1947): An electrical hypothesis of central inhibition. Nature 159:760–764.PubMedCrossRefGoogle Scholar
  5. Coombs, J.S., Eccles, J.C., and Fatt, P. (1953): The action of the inhibitory synaptic transmitter. Aust. J. Sci. 16:1–5.Google Scholar
  6. Coombs, J.S., Eccles, J.C., and Fatt, P. (1955): The specific ionic conductances and the ionic movements across the motoneuronal membrane that produce the inhibitory post-synaptic potential. J. Physiol. 130:326–373.PubMedGoogle Scholar
  7. Dale, H. (1937): Transmission of nervous effects by acetylcholine. Harvey Lect. 32:229–245.Google Scholar
  8. Dale, H.H. (1954): The beginnings and the prospects of neurohumoral transmission. Pharm. Rev. 6:7–13.PubMedGoogle Scholar
  9. Eccles, J.C. (1936): Synaptic and neuromuscular transmission. Ergeb. Physiol. 38:339–444.Google Scholar
  10. Eccles, J.C. (1946): An electrical hypothesis of synaptic and neuro-muscular transmission. Ann. NY Acad. Sci. 47:429–455.CrossRefGoogle Scholar
  11. Eccles, J.C (1957): The Physiology of Nerve Cells. Baltimore: The Johns Hopkins Press.Google Scholar
  12. Eccles, J.C (1964a): The Physiology of Synapses. Berlin: Springer-Verlag.CrossRefGoogle Scholar
  13. Eccles, J.C. (1964b): Ionic mechanism of postsynaptic inhibition. In: Les Prix Nobel en 1963. Stockholm: P.A. Norstedt and Söner, pp. 261–283.Google Scholar
  14. Eccles, J.C., Fatt, P., and Koketsu, K. (1953): Cholinergic and inhibitory synapses in a central nervous pathway. Aust. J. Sci. 16:50–54.Google Scholar
  15. Eccles, J.C., Fatt, P., and Koketsu, K. (1954): Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motoneurones. J. Physiol. 126:524–562.PubMedGoogle Scholar
  16. Eccles, J.C., Fatt, P., and Landgren, S. (1953): The “direct” inhibitory pathway in the spinal cord. Aust. J. Sci. 16:130–134.Google Scholar
  17. Eccles, J.C., Fatt, P., and Landgren, S. (1956): Central pathway for direct inhibitory action of impulses in largest afferent nerve fibres to muscle. J. Neurophysiol. 19:75–98.PubMedGoogle Scholar
  18. Eccles, J.C., and Hoff, H.E. (1932): The rhythmic discharge of motoneurones. Proc. R. Soc. B. 110:483–514.CrossRefGoogle Scholar
  19. Eccles, J.C., Katz, B., and Kuffler, S.W. (1941): Electric potential changes accompanying neuromuscular transmission. Biol. Symp. 3:349–370.Google Scholar
  20. Eccles, J.C., and O’Connor, W.J. (1938): Action potentials evoked by indirect stimulation of curarized muscle. J. Physiol. 94:9–11P.Google Scholar
  21. Eccles, J.C., and Sherrington, C.S. (1930): Numbers and contraction-values of individual motor-units examined in some muscles of the limb. Proc. R. Soc. B. 106:326–357.CrossRefGoogle Scholar
  22. Fatt, P., and Katz, B. (1950): Membrane potentials at the motor endplate. J. Physiol. 111:46–47P.Google Scholar
  23. Feng, T.P. (1940): Studies on the neuromuscular junction. XVIII. The local potentials around N-M junctions induced by single and multiple volleys. Chin. J. Physiol. 15:367–404.Google Scholar
  24. Göpfert, H., and Schaefer, H. (1938): Über den direkt und indirekt erregten Aktionsström und die Funktion der motorischen Endplatte. Pfluegers Arch. Gesamte Physiol. 239:597–619.CrossRefGoogle Scholar
  25. Hultborn, H., Jankowska, E., and Lindström, S. (1971): Recurrent inhibition of interneurones monosynaptically activated from group Ia afferents. J. Physiol. 215:613–636.PubMedGoogle Scholar
  26. Leksell, L. (1945): The action potential and excitatory affects of the small ventral root fibres to skeletal muscle. Acta Physiol. Scand. 10 (Suppl. 31):l-84.Google Scholar
  27. Lloyd, D.P.C. (1946): Facilitation and inhibition of spinal motoneurons. J. Neurophysiol. 9:421–438.PubMedGoogle Scholar
  28. Nastuk, W.L., and Hodgkin, A.L. (1950): The electrical activity of single muscle fibers. J. Cell. Comp. Physiol. 35:39–73.CrossRefGoogle Scholar
  29. Renshaw, B. (1946): Central effects of centripetal impulses in axons of spinal ventral roots. J. Neurophysiol. 9:191–204.PubMedGoogle Scholar
  30. Sherrington, C. (1906): The Integrative Action of the Nervous System. New Haven: Yale University Press.Google Scholar
  31. Sherrington, C. (1924): Problems of muscular receptivity. Nature 113:892–894 and 929–932.Google Scholar
  32. Sherrington, C. (1940): Man on His Nature. London: Cambridge University Press.Google Scholar
  33. Wilson, V.J., and Burgess, P.R. (1962): Disinhibition in the cat spinal cord. J. Neurophysiol. 25: 392–404.PubMedGoogle Scholar

Copyright information

© Birkhäuser Boston 1992

Authors and Affiliations

  • John G. Eccles

There are no affiliations available

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