Targeted Cellular Cytotoxicity

  • David M. Segal
  • Carolina R. Jost
  • Andrew J. T. George


Cell-mediated cytolysis occurs when a cytotoxic cell binds and delivers a “lethal hit” to a target cell. Several types of cells commonly found in blood are capable of performing cytolysis, including monocytes, neutrophils, eosinophils, natural killer (NK) cells, platelets, and T lymphocytes. The T-cell receptors (TCR) on T cells and the Fc γ receptors (Fc γ R) on myeloid cells, NK cells, and platelets are two well-characterized families of cell surface glycoproteins that are involved in binding target cells and triggering lysis.


Effector Cell Bispecific Antibody Parental Antibody Bispecific Monoclonal Antibody Idiotypic Determinant 
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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • David M. Segal
  • Carolina R. Jost
  • Andrew J. T. George

There are no affiliations available

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