The Role of CD8-Class I Interactions in CTL Function

  • Anne M. O’Rourke
  • Matthew F. Mescher


With few exceptions, cytotoxic T lymphocytes (CTL) are activated to lyse cells that bear surface antigen displayed in the context of major histocompatibility complex (MHC) class I proteins. Although recognition of antigen per se is a function of the polymorphic T-cell receptor complex (TCR/CD3), expression of the CD8 glycoprotein correlates with restriction of the CTL to class I protein, and CD8 has been shown to interact with non-polymorphic residues in the class I α3 domain (Salter et al., 1990). Considerable evidence has now accumulated to demonstrate the critical role this interaction plays in adhesion and signal generation for CTL effector function (reviewed in Parnes, 1989).


Degranulation Response Irrelevant Class 
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© Birkhäuser Boston 1993

Authors and Affiliations

  • Anne M. O’Rourke
  • Matthew F. Mescher

There are no affiliations available

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