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The Role of CD8-Class I Interactions in CTL Function

  • Anne M. O’Rourke
  • Matthew F. Mescher

Abstract

With few exceptions, cytotoxic T lymphocytes (CTL) are activated to lyse cells that bear surface antigen displayed in the context of major histocompatibility complex (MHC) class I proteins. Although recognition of antigen per se is a function of the polymorphic T-cell receptor complex (TCR/CD3), expression of the CD8 glycoprotein correlates with restriction of the CTL to class I protein, and CD8 has been shown to interact with non-polymorphic residues in the class I α3 domain (Salter et al., 1990). Considerable evidence has now accumulated to demonstrate the critical role this interaction plays in adhesion and signal generation for CTL effector function (reviewed in Parnes, 1989).

Keywords

Degranulation Response Irrelevant Class 
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References

  1. Balk SP, Mescher MF (1981): Specific reversal of cytolytic T lymphocyte-target cell binding is induced by free target cells. J Immunol 127: 51–57Google Scholar
  2. Balk SP, Walker J, Mescher MF (1981): Kinetics of cytolytic T lymphocyte binding to target cells. J Immunol 126: 2177–2183Google Scholar
  3. Barber EK, Dev Dasgupta J, Schlossman SF, Trevllyan JM, Rudd CE (1989): The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56i°k) that phosphorylates the CD3 complex. Proc Natl Acad Sci USA 86: 3277–3281CrossRefGoogle Scholar
  4. Christinck ER, Luscher MA, Barber BH, Williams DB (1991): Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis. Nature 352: 67–70CrossRefGoogle Scholar
  5. Detmers PA, Wright SD, Olsen E, Kimball B, Cohn ZA (1987): Aggregation of complement receptors on human neutrophils in the absence of ligand. J Cell Biol 105: 1137–1145CrossRefGoogle Scholar
  6. Dustin ML, Springer TA (1989): T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341: 619–624CrossRefGoogle Scholar
  7. Garcia-Penarrubia P, Bankhurst AD (1989): Kinetic analysis of effector cell recylcing and effector-target binding capacity in a model of cell-mediated cytotoxicity. J Immunol 143: 2101–2111Google Scholar
  8. Goldstein SAN, Mescher MF (1987): Cytotoxic T cell activation by class I protein on cell-size artificial membranes: Antigen density and Lyt-2/3 function. J Immunol 138: 2034–2043Google Scholar
  9. Hahn WC, Rosenstein Y, Burakoff SJ, Bierer BE (1991): Interaction of CD2 with its ligand lymphocyte function-associated antigen-3 induces adenosine 3’,5’-cyclic monophosphate production in T lymphocytes. J Immunol 147: 14–21Google Scholar
  10. Irving BA, Weiss A (1991): The cytoplasmic domain of the T cell receptor chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 64: 891–901CrossRefGoogle Scholar
  11. June CH, Fletcher MC, Ledbetter JA, Samelson LE (1990): Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J Immunol 144: 1591–1599Google Scholar
  12. Kane KP, Champoux P, Mescher MF (1989a): Solid-phase binding of class I and class II MHC proteins: Immunoassay and T cell recognition. Mol Immunol 26: 759–768CrossRefGoogle Scholar
  13. Kane KP, Goldstein SAN, Mescher MF (1988): Class I alloantigen is sufficient for cytolytic T lymphocyte binding and transmembrane signalling. Eur J Immunol 18: 1925–1929CrossRefGoogle Scholar
  14. Kane KP, Vitiello A, Sherman LA, Mescher MF (1989b): Cytolytic T lymphocyte response to isolated class I H-2 proteins and influenza peptides. Nature 340: 157–159CrossRefGoogle Scholar
  15. Larson RS, Hibbs ML, Springer TA (1990): The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated. Cell Reg 1: 359–367Google Scholar
  16. Martz E (1976): Multiple target cell killing by cytolytic T lymphocytes and the mechanism of cytotoxicity. Transplantation 21: 5–11CrossRefGoogle Scholar
  17. Martz E (1977): Mechanism of specific tumor cell lysis by alloimmune T-lymphocytes: Resolution and characterization of discrete steps in the cellular interaction. Contemp Top Immunobiol 7: 301–361Google Scholar
  18. Martz E (1987): LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes. Human Immunol 18: 3–37CrossRefGoogle Scholar
  19. Mescher MF, O’Rourke AM, Champoux P, Kane KP (1991): Equilibrium binding of cytotoxic T lymphocytes to class I antigen. J Immunol 147: 36–41Google Scholar
  20. Mustelin T, Coggeshall KM, Isakov N, Altman A (1990): T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 247: 1584–1587CrossRefGoogle Scholar
  21. Nakauchi H, Nolan GP, Hsu C, Huang HS, Kavathas P, Herzenberg LA (1985): Molecular cloning of Lyt2, a membrane glycoprotein marking a subset of mouse T lymphocytes: Molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions. Proc Natl Acad Sci USA 82: 5126–5130CrossRefGoogle Scholar
  22. O’Rourke AM, Mescher MF (1990): T-cell receptor-activated adhesion systems. Curr Opinion Cell Biol 2: 888–893CrossRefGoogle Scholar
  23. O’Rourke AM, Mescher MF (1992): Cytotoxic T lymphocyte activation involves a cascade of signalling and adhesion events. Nature 358: 253–255CrossRefGoogle Scholar
  24. O’Rourke AM, Apgar JR, Kane KP, Martz E, Mescher MF (1991): Cytoskeletal function in CD8- and T cell receptor-mediated interaction of cytotoxic T lymphocytes with class I protein. J Exp Med 173: 241–249CrossRefGoogle Scholar
  25. O’Rourke AM, Rogers J. Mescher MF (1990): Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling. Nature 346: 187–189CrossRefGoogle Scholar
  26. Panaccio M, Gillespie, MT, Walker ID, Kirszbaum L, Sharpe JA, Tobias GH, McKenzie IFC, Deacon NJ (1987): Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8). Proc Natl Acad Sci USA 84: 6874–6878CrossRefGoogle Scholar
  27. Pardi R, Bender JR, Dettori C, Giannazza E, Engleman EG (1989): Heterogeneous distribution and transmembrane signalling properties of lymphocyte function-associated antigen (LFA-I) in human lymphocyte subsets. J Immunol 143: 3157–3166Google Scholar
  28. Parnes JR (1989): Molecular biology and function of CD4 and CD8. Adv Immunol 44: 265–311CrossRefGoogle Scholar
  29. Plaut M, Lichtenstein LM, Henney CS (1973): Studies on the mechanisms of lymphocyte mediated cytolysis III. The role of microfilaments and microtubules. J Immunol 110: 771–780Google Scholar
  30. Salter RD, Benjamin RJ, Wesley PK, Buxton SE, Garrett TP, Clayberger C, Krensky AM, Norment AM, Littmann DR, Parham P (1990): A binding site for the T-cell co-receptor CD8 on the x3 domain of HLA-A2. Nature 345: 41–46CrossRefGoogle Scholar
  31. Samelson LE, Phillips AF, Luong ET, Klausner RD (1990): Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Nat! Acad Sci USA 87: 4358–4362CrossRefGoogle Scholar
  32. Secrist JP, Karnitz L, Abraham RT (1991): T-cell antigen receptor ligation induced tyrosine phosphorylation of phospholipase C-7l. J Biol Chem 266: 12135–12139Google Scholar
  33. Shimizu Y, van Seventer GA, Horgan KJ, Shaw S (1990a): Regulated expression and binding of three VLA (ßl) integrin receptors on T cells. Nature 345: 250–253CrossRefGoogle Scholar
  34. Shimizu Y, van Seventer GA, Horgan KJ, Shaw S (1990b): Roles of adhesion molecules in T-cell recognition: Fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and constimulation. Immunol Rev 114: 109–143CrossRefGoogle Scholar
  35. Shimizu Y, van Seventer GA, Horgan KJ, Shaw S (1990c): Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol 145: 59–67Google Scholar
  36. Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ (1987): Regulation of transmembrane signalling by receptor phosphorylation. Cell 48: 913–922CrossRefGoogle Scholar
  37. Strom TB, Garovoy MR, Carpenter CB, Merrill JP (1973): Microtubule function in immune and non-immune lymphocyte mediated cytotoxicity. Science 181: 171–173CrossRefGoogle Scholar
  38. Ullrich A, Schlessinger J (1990): Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203–212CrossRefGoogle Scholar
  39. van Kooyk Y, van de Wiel-van Kemenade P, Weder P, Kuijpers TW, Figdor CG (1989): Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 342: 811–813Google Scholar
  40. van Kooyk Y, Weder P, Hogervorst F, Verhoeven AJ, van Seventer G, te Velde AA, Borst J, Keizer GD, Figdor CG (1991): Activation of LFA-I through a Ca’ + -dependent epitope stimulates lymphocyte adhesion. J Cell Biol. 112: 345–354CrossRefGoogle Scholar
  41. van Seventer GA, Shimizu Y, Horgan KJ, Shaw S (1990): The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J Immunol 144: 4579–4586Google Scholar
  42. Veillette A, Bookman MA, Horak EM, Bolen JB (1988): The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56. Cell 55: 301–308CrossRefGoogle Scholar
  43. Vitiello A, Potter TA, Sherman LA (1990): The role of ß2-microglobulin in peptide binding by class I molecules. Science 250: 1423–1426CrossRefGoogle Scholar
  44. Weiss A, Koretzky G, Schatzman RC, Kadlecek T (1991): Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase Cil. Proc Natl Acad Sci USA 88: 5484–5488CrossRefGoogle Scholar
  45. Zagury D, Bernard J, Thierness N, Feldman M, Berke G (1975): Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes: Conjugation, killing and recycling at the single cell level. Eur J Immunol 5: 818–822CrossRefGoogle Scholar

Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Anne M. O’Rourke
  • Matthew F. Mescher

There are no affiliations available

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