CTL Recognition of Purified MHC Antigens and Other Cell Surface Ligands

  • Matthew F. Mescher
  • Paul Champoux
  • Kevin P. Kane


T-cell receptor binding to peptide antigen-major histocompatibility complex (MHC) complexes or MHC alloantigen clearly plays the central role in activating T-cell responses. However, as discussed elsewhere in this volume, a number of additional receptor-ligand interactions, including LFA-1/ 1CAM, CD8/class 1, and binding of VLA to fibronectin or laminins, can either be required to initiate response or contribute to increased response levels. Both the types and amounts (surface densities) of ligands present on a target cell can determine the levels of responses, and may also determine whether a particular response occurs (e.g., proliferation vs. production of cytokines).


Additional Ligand Latex Microsphere Antigen Solution Planar Lipid Membrane Cell Surface Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Matthew F. Mescher
  • Paul Champoux
  • Kevin P. Kane

There are no affiliations available

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