Derivatization of Cells with Antibody

  • Anna Ratner
  • William R. Clark


This technique is very useful for redirected lysis of target cells which are otherwise not recognized by a particular CTL. Target cells are derivatized with antibody specific either for the α- or β-chain of the T-cell receptor (TCR), or for a member of the CD-3 complex of TCR-associated proteins. Useful control antibodies are class I or CD-8, neither of which should induce target cell lysis.


Target Cell Room Tempera Sulfhydryl Group Cytotoxic Cell Molar Excess 
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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Anna Ratner
  • William R. Clark

There are no affiliations available

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