Class I MHC/Peptide/ β2-Microglobulin Interactions:The Basis of Cytotoxic T-Cell Recognition

  • David H. Margulies
  • Lisa F. Boyd
  • Maripat Corr
  • Rosemarie D. Hunziker
  • Sergei Khilko
  • Steven Kozlowski
  • Michael Mage
  • Randall K. Ribaudo


The past decade has witnessed a major revolution in our thinking and understanding of the molecular basis of T-cell recognition. In this brief review we outline the historical development of this knowledge and how it has drawn upon advances in cellular immunology, virology, genetics, molecular biology, and structural biology. The current status of our view of the molecular details is summarized, and an outline of critical molecular and cellular questions for the future is presented.


Murine Class Specific Antigenic Peptide Cell Surface Class Human Histocompatibility Antigen 
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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • David H. Margulies
  • Lisa F. Boyd
  • Maripat Corr
  • Rosemarie D. Hunziker
  • Sergei Khilko
  • Steven Kozlowski
  • Michael Mage
  • Randall K. Ribaudo

There are no affiliations available

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