The Immunosenescence of Cytolytic T Lymphocytes (CTL): Reduction of Pore-Forming Protein and Granzyme Levels

  • Eda T. Bloom
  • Judith A. Horvath


The decline in immunologic vigor that accompanies advancing age has been recognized for many years, and immunologic senescence has been the focus of two recent and extensive reviews (Thoman and Weigle, 1989; Miller, 1990). Although all immunologically active cells, including T cells, B cells, macrophages, and natural killer (NK) cells, appear to exhibit age-related alterations in one or more functions, T cells are widely considered to be the most vulnerable to the potentially deleterious effects of aging. Thymic involution, morphological evidence for which can be observed soon after the immune system functionally matures, is thought to be intimately connected with the subsequent decline in T-cell function (Hirokawa et al., 1990). Although evidence suggests that extrathymic T-cell development is also altered with advanced age (Gorczynski and Chang, 1984), the mechanisms are not yet understood.


Aged Mouse Lytic Activity Young Mouse Mixed Lymphocyte Culture Serine Esterase 
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© Birkhäuser Boston 1993

Authors and Affiliations

  • Eda T. Bloom
  • Judith A. Horvath

There are no affiliations available

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