Can CTL Control Virus Infections Without Cytolysis? The Prelytic Halt Hypothesis

  • Eric Martz


There is excellent evidence that T cells are required for control of most virus infections and that cloned cytotoxic T lymphocytes (CTL) are sufficient for such control (reviewed in Martz and Howell, 1989; see also Moskophidis et al., 1989). In three cases that have been tested, control of one virus fails to control a second virus in a mixed infection (Lukacher et al., 1984; Maclntyre et al., 1985; Scherle et al., 1992). This evidence for control by a bystander-sparing effector action is consistent with control by the contact-dependent lytic action of CTL. It speaks against a nonspecific CTL effector mechanism such as release of inter-ferons or other antireplicating cytokines, or activation of phagocytes by cytokines released by CTL and other cells, at least to the extent that the actions of such mediators would be “long-range,” spilling into the compartment infected with bystander virus.


Lymphocytic Choriomeningitis Acute Virus Latent Herpes Simplex Virus Infection Common Target Cell 
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© Birkhäuser Boston 1993

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  • Eric Martz

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