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CD4+ and CD8+ Cytolytic T Lymphocyte Recognition of Viral Antigens

  • Vivian Lam Braciale

Abstract

An enormous amount of work by many laboratories has brought us to our present understanding of the T cell-mediated immune response to viruses. To be reviewed here are some observations from our own work on the cytotoxic T-lymphocyte (CTL) responses to influenza virus which provides a glimpse of some of the issues addressed by laboratories in this area as well as the evolution of the direction of the field of viral immunology. Since the mid-1970s, the study of the cell-mediated immune responses to viruses has provided insight into the nature of T-lymphocyte recognition, the pathways of foreign antigen processing and presentation, and the biology of the cytotoxic T effector subset. It was first appreciated in studies with lymphocytic choriomeningitis virus (LCMV) by Zinkernagel and Doherty (1974) that T lymphocytes recognize viral antigens in a major histocompatibility complex (MHC)-restricted fashion. This led the way to studies dealing with the elucidation of the T-cell receptor, one that would seemingly need to be as diverse as the B-cell receptor, as well as studies of the MHC class I products in an effort to divine how the T cell can recognize both foreign antigen and the self-MHC product.

Keywords

Major Histocompatibility Complex Influenza Virus Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Influenza Hemagglutinin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Vivian Lam Braciale

There are no affiliations available

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