CD4+ and CD8+ Cytolytic T Lymphocyte Recognition of Viral Antigens

  • Vivian Lam Braciale


An enormous amount of work by many laboratories has brought us to our present understanding of the T cell-mediated immune response to viruses. To be reviewed here are some observations from our own work on the cytotoxic T-lymphocyte (CTL) responses to influenza virus which provides a glimpse of some of the issues addressed by laboratories in this area as well as the evolution of the direction of the field of viral immunology. Since the mid-1970s, the study of the cell-mediated immune responses to viruses has provided insight into the nature of T-lymphocyte recognition, the pathways of foreign antigen processing and presentation, and the biology of the cytotoxic T effector subset. It was first appreciated in studies with lymphocytic choriomeningitis virus (LCMV) by Zinkernagel and Doherty (1974) that T lymphocytes recognize viral antigens in a major histocompatibility complex (MHC)-restricted fashion. This led the way to studies dealing with the elucidation of the T-cell receptor, one that would seemingly need to be as diverse as the B-cell receptor, as well as studies of the MHC class I products in an effort to divine how the T cell can recognize both foreign antigen and the self-MHC product.


Major Histocompatibility Complex Influenza Virus Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Influenza Hemagglutinin 
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© Birkhäuser Boston 1993

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  • Vivian Lam Braciale

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