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Role of CD8+αβ T Cells in Respiratory Infections Caused by Sendai Virus and Influenza Virus

  • Peter C. Doherty
  • William Allan
  • Maryna Eichelberger
  • Sam Hou
  • Jacqueline M. Katz
  • Rudolf Jaenisch
  • Maarten Zijlstra

Abstract

Current understanding of the part played by CD8+ αβ T cells in respiratory virus infections is based on findings from a spectrum of approaches. These include direct analysis of the patterns of lymphocyte involvement in the virus-infected lung (McDermott et al., 1987; Pena-Cruz et al., 1989; Allan et al., 1990; Openshaw, 1991; Eichelberger et al., 1991b), adoptive transfer experiments utilizing either bulk immune T-cell populations or cell lines (Leung and Ada, 1992; Lukacher et al., 1984, 1986; Ada and Jones, 1986; Taylor and Askonas, 1986; Kast et al., 1986; Cannon et al., 1987; Askonas et al., 1988; Mackenzie et al., 1989), in vivo depletion with monoclonal antibody (mAb) (Lightman et al., 1987; Waldmann, 1989; Allan et al., 1990; Eichelberger et al., 1991b), and the use of H-2 mutant or genetically manipulated mice (de Waal et al., 1983; Eichelberger et al., 1991b).

Keywords

Major Histocompatibility Complex Influenza Virus Mediastinal Lymph Node Sendai Virus Adoptive Transfer Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Peter C. Doherty
  • William Allan
  • Maryna Eichelberger
  • Sam Hou
  • Jacqueline M. Katz
  • Rudolf Jaenisch
  • Maarten Zijlstra

There are no affiliations available

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