Identification of Protein Kinases and Protein Phosphatases Involved in CTL Effector Functions. “ON” and “OFF” Signaling and Immunopharmacological Implications

  • Hirotaka Sugiyama
  • Sergey Apasov
  • Guido Trenn
  • Frank Redegeld
  • Michail Sitkovsky


Biochemical studies of cytotoxic T-lymphocyte (CTL) effector functions, the description of molecular requirements, and the enzymes needed for CTL-induced target cell (TC) death are likely to shed light on the mechanisms and individual participants of practically all steps of CTL-TC interactions (Lancki et al., 1986). These mechanisms include conjugate formation, lethal hit delivery, and events leading to TC death. Identification of important regulatory molecules will also provide key targets for immunomodulation and allow for design of specific pharmacological agents.


Protein Phosphatase Phorbol Ester Okadaic Acid Granule Exocytosis Serine Esterase 


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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Hirotaka Sugiyama
  • Sergey Apasov
  • Guido Trenn
  • Frank Redegeld
  • Michail Sitkovsky

There are no affiliations available

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