Overview of CTL-Target Adhesion and Other Critical Events in the Cytotoxic Mechanism

  • Eric Martz


Despite decades of work and much real progress, the mechanisms by which cytotoxic T lymphocytes (CTL) damage target cells remain largely obscure. In addition, the question has been raised whether cytolysis is the primary antiviral effector mechanism employed by CTL in vivo (Martz and Howell, 1989). Greater progress has been made in understanding the mechanisms by which CTL adhere to targets. Many of the molecules involved in recognition and adhesion have been identified, although the mechanism of adhesion-strengthening, the recognition-controlled rapid increase in avidity of adhesion molecules for target ligands, remains to be elucidated.


Cognate Target Bystander Killing Target Cell Conjugate MTOC Reorientation 


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© Birkhäuser Boston 1993

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  • Eric Martz

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