Cell-Permeabilizing Properties of Extracellular ATP in Relation to Lymphocyte-Mediated Cytotoxicity

  • Francesco Di Virgilio
  • Paola Zanovello
  • Dino Collavo


Although the phenomenon of lymphocyte-mediated cytotoxicity is well known, the underlying mechanisms are at present a hotly debated issue because the molecular participants involved still elude definition (Berke, 1991; Krahenbuhl and Tschopp, 1991). Although perforin is a well-characterized cytocidal mediator, much evidence indicates that other molecules are implicated (Trenn et al., 1987). In the last three years, we have explored the possibility that extracellular ATP (ATPo) might constitute a mediator of lymphocyte-mediated cytotoxicity (Di Virgilio et al., 1989; Zanovello et al., 1990; Di Virgilio et al., 1990)


Mouse Lymphocyte Target Cell Killing Target Cell Death Eosin Yellowish Bronte Versus 
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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Francesco Di Virgilio
  • Paola Zanovello
  • Dino Collavo

There are no affiliations available

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