Abstract
The nature of the so-called lethal hit that causes target cells (TC) to die after a relatively short encounter with cytotoxic T lyphocytes (CTL) is of great interest not only to immunologists. This problem is also very challenging to those who realize that CTL-TC interactions present an interesting model system in which contacts between two different cells-(CTL) and antigen (Ag)-bearing (TC)-result in dramatic consequences for both participants: the CTL is activated due to the crosslinking of the T-cell receptor (TCR) with the Ag. whereas the TC eventually dies (Goldstein, 1987).
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Redegeld, F., Filippini, A., Trenn, G., Sitkovsky, M.V. (1993). Possible Role of Extracellular ATP in Cell-Cell Interactions Leading to CTL-Mediated Cytotoxicity. In: Sitkovsky, M.V., Henkart, P.A. (eds) Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6814-4_28
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DOI: https://doi.org/10.1007/978-1-4684-6814-4_28
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