Molecular Analysis and Possible Pleiotropic Function(s) of the T Cell-Specific Serine Proteinase-1 (TSP-1)

  • Markus M. Simon
  • Klaus Ebnet
  • Michael D. Kramer


Recovery from infection requires the induction of relevant effector functions of lymphocytes and their focus to appropriate sites. T lymphocytes play a pivotal role in these complex biological processes. They act not only as regulator and effector cells during the development of both humoral and cellular immune responses, but are also able to interact with and control the physiology of nonimmune cells such as endothelial cells and fibroblasts (Cavender, 1989, 1990; Springer, 1990; Shimizu et al., 1989, 1990, 1991) during extravasation and their performance within infectious foci (Abraham et al., 1989).


Serine Protease Cytoplasmic Granule PLEIOTROPIC Function Vascular Basement Membrane Infected Target Cell 


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© Birkhäuser Boston 1993

Authors and Affiliations

  • Markus M. Simon
  • Klaus Ebnet
  • Michael D. Kramer

There are no affiliations available

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