Abstract
Granzyme A, initially termed Hanukkah factor (HF) in this laboratory, is a serine protease contained within specialized cytoplasmic granules of activated cytolytic lymphocytes (CTL). These granules contain other granzymes, proteoglycans, and a pore-forming protein termed perforin (Podack, 1989). The granules and the proteins contained within them appear only after T-cell activation occurs, and their exocytosis seems to account for at least one mechanism of lymphocyte cytotoxicity. Whether this is the only mechanism remains controversial (Chapters 16, 18, 28, this volume; Berke, 1991; Krahenbuhl and Tschopp, 1991).
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© 1993 Birkhäuser Boston
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Griffiths, G.M., Alpert, S., Hershberger, R.J., Su, L., Weissman, I.L. (1993). The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo. In: Sitkovsky, M.V., Henkart, P.A. (eds) Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6814-4_25
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DOI: https://doi.org/10.1007/978-1-4684-6814-4_25
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4684-6816-8
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