The Role of Granzyme A in Cytotoxic Lymphocyte-Mediated Lysis

  • Mark S. Pasternack


Despite considerable information regarding the structure and expression of granzymes, the serine proteases that reside in the cytotoxic granules of cytotoxic T lymphocytes (CTL), little is known about their physiologic substrates or their role in the economy of these effector cells. From a conceptual framework, such proteases may act on the effector cells themselves (“cis” action), on the target cells (“trans”), or in a more nonspecific fashion; current information remains sketchy and controversial. In this chapter, the functional properties and possible physiologic roles of CTL granzymes will be reviewed, with particular reference to granzyme A.


Large Granular Lymphocyte Target Cell Lysis Cytotoxic Granule Serine Esterase Mediate Lysis 
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© Birkhäuser Boston 1993

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  • Mark S. Pasternack

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