T-Cell-Mediated Cytotoxicity: A Historical Note
On May 15, 1967, the editor of the British journal Immunology found on his desk a manuscript submitted for publication, the Summary section of which read as follows: “The in vitro cytotoxic effect of spleen cells of mice immunized by tumor allo-grafts was studied by measuring target cell inactivation as a function of release of radioactive label (51Cr) or loss of cloning efficiency.” The first author of this paper was Teddy Brunner, head of the Department of Immunology at the Swiss Institute for Experimental Cancer Research in Lausanne. The manuscript was accepted and was published in February 1968 (Brunner et al., 1968). As I have been fortunate enough to be associated with this work, a book such as this offers me an opportunity to give a brief personal account of the “early days” of T-cell-mediated cytotoxicity.
KeywordsBone Marrow Cell Spleen Cell Cytotoxic Cell P815 Cell Thymus Cell
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