T-Cell-Mediated Cytotoxicity: A Historical Note

  • Jean-Charles Cerottini


On May 15, 1967, the editor of the British journal Immunology found on his desk a manuscript submitted for publication, the Summary section of which read as follows: “The in vitro cytotoxic effect of spleen cells of mice immunized by tumor allo-grafts was studied by measuring target cell inactivation as a function of release of radioactive label (51Cr) or loss of cloning efficiency.” The first author of this paper was Teddy Brunner, head of the Department of Immunology at the Swiss Institute for Experimental Cancer Research in Lausanne. The manuscript was accepted and was published in February 1968 (Brunner et al., 1968). As I have been fortunate enough to be associated with this work, a book such as this offers me an opportunity to give a brief personal account of the “early days” of T-cell-mediated cytotoxicity.


Bone Marrow Cell Spleen Cell Cytotoxic Cell P815 Cell Thymus Cell 


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  1. Brunner KT, Mauël J., Cerottini JC, Chapuis B (1968): Quantitative assay of the lytic action of immune lymphoid cells on ’ CR-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunology 14: 181–196Google Scholar
  2. Brunner KT, Mauël J, Cerottini JC, Rudolf H, Chapuis B (1967a): In vitro studies of cellular and humoral immunity induced by tumor allografts. In: Vth International Immunopathology Symposium, Miescher PA, Grabar P, eds. Basel/Stuttgart: Schwabe & Co., pp. 342–355Google Scholar
  3. Brunner KT, Mauël J, Schindler R (1966): In vitro studies of cell-bound immunity; cloning assay of the cytotoxic action of sensitized lymphoid cells on allogeneic target cells. Immunology 11: 499–506Google Scholar
  4. Brunner KT, Mauël J, Schindler R (1967b): Inhibitory effect of isoantibody on in vivo sensitization and on the in vitro cytotoxic action of immune lymphocytes. Nature 213: 1246–1247CrossRefGoogle Scholar
  5. Cerottini JC, Brunner KT (1974): Cell-mediated cytotoxicity, allograft rejection and tumor immunity. Adv Immunol 18: 67–132CrossRefGoogle Scholar
  6. Cerottini JC, Nordin AA, Brunner KT (1970a): In vitro cytotoxic activity of thymus cells sensitized to alloantigens. Nature 227: 72–73CrossRefGoogle Scholar
  7. Cerottini JC, Nordin AA, Brunner KT (1970b): Specific in vitro cytotoxicity of thymus-derived lymphocytes sensitized to alloantigens. Nature 228: 1308–1309CrossRefGoogle Scholar
  8. Cerottini JC, Nordin AA, Brunner KT (1970c): Competence of various cell populations for humoral and cell-mediated transplantation immunity. In: Vlth International Immunopathology Symposium, Miescher PA, ed. Basel/Stuttgart: Schwabe & Co., pp. 97–103Google Scholar
  9. Cerottini JC, Nordin AA, Brunner KT (1971): Cellular and humoral response to transplantation antigens. I. Development of alloantibody-forming cells and cytotoxic lymphocytes in the graft-becsus-host reaction. J Exp Med 134: 553–564CrossRefGoogle Scholar
  10. Nordin AA, Cerottini JC, Brunner KT (1971): The antibody response of mice to allografts as determined by a plaque assay with allogeneic target cells. Eur J Immunol 1: 55–56CrossRefGoogle Scholar

Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Jean-Charles Cerottini

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