The Granule Exocytosis Model for Lymphocyte Cytotoxicity and Its Relevance to Target Cell DNA Breakdown

  • Pierre A. Henkart
  • Mark P. Hayes
  • John W. Shiver


The granule exocytosis model for lymphocyte cytotoxicity was proposed some years ago (Henkart and Henkart, 1982, Henkart, 1985) and has become generally accepted as one pathway which cytotoxic lymphocytes use to kill target cells (Krahenbuhl and Tschapp, 1991). The model is appealing because it can account for most of the classically known properties of lymphocyte cytotoxicity, and it utilizes a basic process well known to cell biology: the regulated pathway of protein secretion (Henkart et al., 1987b). Indeed, it remains the only well-defined model which accounts for the rapid, lymphocyte-mediated death of target cells in vitro. However, there remain questions as to whether it is the major pathway of cytotoxicity, as it seems likely that cytotoxic T lymphocytes (CTL) can sometimes kill when this pathway is inoperative (Ostergaard et al., 1987; Trenn et al., 1987).


Lymphocyte Cytotoxicity Granule Exocytosis Granule Component Immune Gamma Globulin Granule Extract 
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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Pierre A. Henkart
  • Mark P. Hayes
    • 1
  • John W. Shiver
    • 2
  1. 1.Division of Cytokine BiologyCBER, FDABethesdaUSA
  2. 2.Merck, Sharp and Dohme Research LaboratoriesWest PointUSA

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