Regulatory Effects of Cytokines on the Generation of CTL and LAK Cells

  • Mark R. Alderson
  • Michael B. Widmer


It has long been recognized that the growth and differentiation of resting mature T lymphocytes into functional helper or cytolytic cells is dependent upon not only an antigenic stimulus but also soluble factors (Plate, 1976; Ryser et al., 1978). Consequently, recent attention has been focused upon the identification and further characterization of these soluble regulators. Following the description of interleukin-2 (IL-2) as a T-cell growth factor that can influence the generation of cytolytic T lymphocytes (CTL) (Gillis et al., 1978), it became apparent that several other cytokines exist which have similar activity. However, many of the early studies on T cell-active factors were clouded by the use of impure cytokine preparations and the possibility of indirect effects occurring in bulk lymphocyte cultures due to cytokine cascades. Thus, it was possible that a reputed T-cell growth factor or CTL induction factor was in fact affecting the secondary production of IL-2 or other T-cell growth factors, rather than itself directly stimulating T cells.


Cell Stimulatory Factor Limit Dilution Analysis Cytolytic Cell Mixed Leukocyte Culture Natural Killer Cell Stimulatory Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Birkhäuser Boston 1993

Authors and Affiliations

  • Mark R. Alderson
  • Michael B. Widmer

There are no affiliations available

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